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    COMPOSITIONS AND METHODS FOR PROMOTING VASCULAR BARRIER FUNCTION AND TREATING PULMONARY FIBROSIS
    1.
    发明申请
    COMPOSITIONS AND METHODS FOR PROMOTING VASCULAR BARRIER FUNCTION AND TREATING PULMONARY FIBROSIS 审中-公开
    用于促进血管阻滞功能和治疗肺动脉纤维化的组合物和方法

    公开(公告)号：WO2010068917A2

    公开(公告)日：2010-06-17

    申请号：PCT/US2009/067746

    申请日：2009-12-11

    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  LI, Dean, Y. ,  LONDON, Nyall ,  ZHU, Weiquan

    Inventor： LI, Dean, Y. ,  LONDON, Nyall ,  ZHU, Weiquan

    IPC: A61K38/17

    CPC classification number: A61K38/1709

    Abstract: Active agents and compositions that promote vascular barrier function are described herein. The compositions described herein include at least one active agent capable of promoting vascular barrier function, and in one such embodiment, the compositions described herein include an active agent that promotes the barrier function of vascular endothelium. Compositions described herein include active agents that inhibits vascular permeability associated with pulmonary inflammation, including vascular permeability associated with conditions leading to or resulting from acute pulmonary inflammation and chronic pulmonary inflammation.

    Abstract translation: 本文描述了促进血管屏障功能的活性剂和组合物。 本文所述的组合物包括至少一种能够促进血管屏障功能的活性剂，并且在一个这样的实施方案中，本文所述的组合物包括促进血管内皮的屏障功能的活性剂。 本文描述的组合物包括抑制与肺部炎症相关的血管通透性的活性剂，包括与导致或由急性肺部炎症和慢性肺部炎症引起的病症相关的血管通透性。

    ACTIVE AGENTS, COMPOSITIONS, AND METHODS FOR INHIBITING AND REVERSING PLATELET FUNCTION
    3.
    发明申请
    ACTIVE AGENTS, COMPOSITIONS, AND METHODS FOR INHIBITING AND REVERSING PLATELET FUNCTION 审中-公开
    活性剂，组合物和抑制和反转平板功能的方法

    公开(公告)号：WO2010048625A1

    公开(公告)日：2010-04-29

    申请号：PCT/US2009/062107

    申请日：2009-10-26

    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  LI, Dean Y. ,  SMITH, Matthew ,  WEYRICH, Andy

    Inventor： LI, Dean Y. ,  SMITH, Matthew ,  WEYRICH, Andy

    IPC: A61K38/00

    CPC classification number: A61K38/1709 ,  C07K14/4703

    Abstract: Active agents, compositions, and methods for inhibiting and reversing platelet function are provided. In particular, the active agents inhibit or reverse platelet function. In particular, the methods described include administration of a Sema3E polypeptide. Further, methods of treating pathologic conditions associated with platelet function (i.e., platelet activation) and methods of screening active agent candidates are also provided.

    Abstract translation: 提供了用于抑制和逆转血小板功能的活性剂，组合物和方法。 特别地，活性剂抑制或逆转血小板功能。 特别地，所述方法包括施用Sema3E多肽。 此外，还提供了治疗与血小板功能相关的病理状况（即血小板活化）的方法和筛选活性剂候选物的方法。

    METHODS OF TREATING AND PREVENTING VASCULAR INSTABILITY DISEASES
    4.
    发明申请
    METHODS OF TREATING AND PREVENTING VASCULAR INSTABILITY DISEASES 审中-公开
    治疗和预防血管不稳定性疾病的方法

    公开(公告)号：WO2015195685A1

    公开(公告)日：2015-12-23

    申请号：PCT/US2015/036062

    申请日：2015-06-16

    Applicant: GIBSON, Christopher C. ,  LI, Dean Y.

    Inventor： GIBSON, Christopher C. ,  LI, Dean Y.

    IPC: A61K31/59

    CPC classification number: A61K31/445 ,  A61B5/004 ,  A61K31/4468 ,  A61K31/45 ,  A61K31/593

    Abstract: Methods are disclosed for treating and preventing vascular instability diseases, such as cerebral cavernous malformation, by the administration of tempol, cholecalciferol, derivatives thereof, pharmaceutically-acceptable salts thereof, or combinations thereof. Methods are disclosed for reducing the number of cerebral cavernous malformation (CCM) lesions in a patient having, or at risk of developing, at least one CCM lesion. Methods are disclosed for reducing the growth rate of the number of cerebral cavernous malformation (CCM) lesions in a patient having, or at risk of developing, at least one CCM lesion. Method are disclosed for preventing or treating a sign or symptom of cerebral cavernous malformation (CCM) in a patient with at least one CCM lesion. Methods are disclosed for decreasing cerebrovascular inflammation, reducing cerebrovascular permeability, or both, in a patient having, or at risk of developing, a cerebral cavernous malformation (CCM) lesion. Methods are disclosed for improving cerebrovascular health in a patient having, or at risk of developing, a cerebral cavernous malformation (CCM) lesion.

    Abstract translation: 公开了用于治疗和预防血管不稳定性疾病如脑海绵体畸形的方法，通过施用温莫酚，胆钙化醇，其衍生物，其药学上可接受的盐或其组合。 公开了用于减少具有或有发展至少一个CCM损伤的风险的患者中的脑海绵体畸形（CCM）损伤的数量的方法。 公开了用于减少患有或已经发展至少一个CCM损伤的患者的脑海绵体畸形（CCM）损伤数量的生长速率的方法。 公开了用于预防或治疗患有至少一个CCM损伤的患者的脑海绵体畸形（CCM）的征兆或症状的方法。 公开了在具有或有发展为脑海绵体畸形（CCM）病变的风险的患者中减少脑血管炎症，降低脑血管通透性或两者的方法。 公开了用于改善患有脑海绵体畸形（CCM）损伤或处于脑海绵体畸形（CCM）病变的风险中的患者的脑血管健康的方法。

    ELASTIN-BASED COMPOSITIONS
    6.
    发明申请
    ELASTIN-BASED COMPOSITIONS 审中-公开
    基于ELASTIN的组合物

    公开(公告)号：WO0050068A3

    公开(公告)日：2001-11-15

    申请号：PCT/US0002526

    申请日：2000-02-28

    Applicant: UNIV UTAH RES FOUND ,  KEATING MARK T ,  LI DEAN Y

    Inventor： KEATING MARK T ,  LI DEAN Y

    IPC: A61K38/39 ,  A61L31/04 ,  A61P9/10 ,  A61F2/00 ,  G01N33/50

    CPC classification number: A61L31/047 ,  A61K38/39 ,  A61L31/043

    Abstract: The present invention provides screening methods that use organisms or cells that lack function in one or both elastin genes. These methods are useful in identifying drugs for the prevention and treatment of obstructive vascular diseases, such as atherosclerosis, vascular restenosis and transplant arteriopathy. Further, the invention provides pharmaceutical compositions containing elastin-based compositions that are particularly potent regulators of proliferation, differentiation, and migration of smooth muscle cells in vitro and in vivo. These pharmaceutical compositions and related methods are useful in the prevention and treatment of disorders characterized by diminished capacity to regulate smooth muscle cell function.

    Abstract translation: 本发明提供使用在一种或两种弹性蛋白基因中缺乏功能的生物体或细胞的筛选方法。 这些方法可用于鉴定用于预防和治疗阻塞性血管疾病如动脉粥样硬化，血管再狭窄和移植物动脉病变的药物。 此外，本发明提供含有基于弹性蛋白的组合物的药物组合物，其是体外和体内平滑肌细胞增殖，分化和迁移的特别有效的调节剂。 这些药物组合物和相关方法可用于预防和治疗以减轻调节平滑肌细胞功能的能力为特征的疾病。

    METHODS AND COMPOSITIONS FOR MANIPULATING THE GUIDED NAVIGATION OF ENDOTHELIAL TUBES DURING ANGIOGENESIS
    8.
    发明申请
    METHODS AND COMPOSITIONS FOR MANIPULATING THE GUIDED NAVIGATION OF ENDOTHELIAL TUBES DURING ANGIOGENESIS 审中-公开
    用于在血管生成期间操纵内皮导管导向的方法和组合物

    公开(公告)号：WO2004003163A2

    公开(公告)日：2004-01-08

    申请号：PCT/US2003/020508

    申请日：2003-06-27

    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  LI, Dean, Y. ,  PARK, Kye, Won

    Inventor： LI, Dean, Y. ,  PARK, Kye, Won

    IPC: C12N

    CPC classification number: C12N5/0691 ,  A61K38/00 ,  C07K14/4702 ,  C07K14/705 ,  C07K14/70503

    Abstract: Methods and compositions for manipulating the directed navigation of physiological tracking tubular structures are provided. A novel cell-bound receptor, roundabout-4 (Robo-4), is described. The Robo-4 receptor shows sequence and structural similarity to members of the roundabout family of receptors. Also, the Robo-4 receptor binds Slit ligand, a known receptor of the roundabout receptors. Polynucleotides and polypeptides of the Robo-4 receptor are described.

    Abstract translation: 提供了用于操纵生理追踪管状结构的定向导航的方法和组合物。 描述了一种新的细胞结合受体，迂回-4（Robo-4）。 Robo-4受体显示与回旋家族受体成员的序列和结构相似性。 此外，Robo-4受体结合Slit配体，这是迂回受体的已知受体。 描述了Robo-4受体的多核苷酸和多肽。

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