公开(公告)号：WO0041725A3

公开(公告)日：2000-11-30

申请号：PCT/US0000848

申请日：2000-01-14

Applicant: LIGHT SCIENCES LTD ,  CHEN JAMES

Inventor： CHEN JAMES

IPC: A61K47/48 ,  A61K31/663 ,  A61K33/42 ,  A61K41/00 ,  A61P19/08 ,  A61P19/10

CPC classification number: A61K41/0057 ,  A61K41/0033 ,  A61K41/0071

Abstract: The present invention is drawn to methods and compositions useful for targeting and treating target tissues affected by or involved in metabolic bone disorders and bone metastases with photodynamic therapy (PDT) in a mammalian subject. The compositions are bisphosphonates, pyrophosphates or bisphosphonate-like compounds conjugated to photosensitive agents which are optionally further conjugated to ligands which are target tissue specific antibodies, peptides or polymers. The methods of PDT treatment utilize these compositions to target the tissues or cells of a mammalian subject to be treated. The methods comprise irradiating at least a portion of the subject with light at a wavelength absorbed by said photosensitizing agent that under conditions of activation during photodynamic therapy using a relatively low fluence rate, but an overall high total fluence dose results in minimal collateral tissue damage.

Abstract translation: 本发明涉及用于靶向和治疗受哺乳动物受试者中的光动力学治疗（PDT）影响或参与代谢骨疾病和骨转移的靶组织的方法和组合物。 组合物是与感光剂缀合的双膦酸盐，焦磷酸盐或二膦酸盐样化合物，其任选地进一步与靶组织特异性抗体，肽或聚合物的配体缀合。 PDT治疗的方法利用这些组合物来靶向待治疗的哺乳动物受试者的组织或细胞。 所述方法包括用光吸收剂吸收的波长的光照射受试者的至少一部分，在光动力疗法的激活条件下，使用相对较低的通量率，但总的高总注量剂量导致最小的侧支组织损伤。

公开(公告)号：WO0015296A8

公开(公告)日：2001-03-01

申请号：PCT/US9919015

申请日：1999-08-20

Applicant: LIGHT SCIENCES LTD PARTNERSHIP

Inventor： CHEN JAMES C ,  WISCOMBE BRENT

IPC: A61N5/06 ,  A61N5/00

CPC classification number: A61N5/062 ,  A61N2005/0645 ,  A61N2005/0652

Abstract: A flexible patch (10) provided with a plurality of light sources (16) mounted in spaced apart array on its undersurface, and covered with an optically transparent polymer material. The light sources (16) are energized with an electrical current supplied by a flexible polymer battery (44), which is preferably rechargeable. Electrical current is conveyed through a lead (42) that extends from the flexible battery to the flexible patch (10) and then through an electrical circuit that includes a plurality of conductive traces (12, 14) formed using a conductive ink applied to the surface of a flexible substrate that supports the light sources. The thickness of the flexible patch (16) at its maximum is less than 1.0 millimeters. The light sources (16) can be separatly grouped, the electrical current supplied to each group individually controlled to achieve a desired light intensity, and/or duration exposure to the light therapy over different portions of the undersurface (40) of the flexible patch (10) with different portions of the treatment site. A plurality of slots (46, 48) that extend through the flexible substrate provide passages for air, for moisture, enabling the flexible substrate to freely, and more readily conform to irregular, non-planer shapes of the treatment site.

Abstract translation: 柔性贴片（10），其设置有多个光源（16），其间隔开地阵列安装在其下表面上，并被光学透明的聚合物材料覆盖。 光源（16）由柔性聚合物电池（44）提供的电流通电，柔性聚合物电池（44）优选是可再充电的。 电流通过从柔性电池延伸到柔性贴片（10）的引线（42）传送，然后通过电路，该电路包括使用施加到表面的导电油墨形成的多个导电迹线（12,14） 支撑光源的柔性基板。 柔性贴片（16）的最大厚度小于1.0毫米。 光源（16）可以被分离地分组，供应给每个组的电流被单独地控制以实现期望的光强度，和/或在柔性贴片的下表面（40）的不同部分上的光疗法的持续时间 10）与治疗部位的不同部位。 延伸穿过柔性基底的多个狭槽（46,48）提供用于空气的通道，用于湿气，使得柔性基底能够自由地，并且更容易地符合治疗部位的不规则的非平面形状。

公开(公告)号：WO0041726A2

公开(公告)日：2000-07-20

申请号：PCT/US0000852

申请日：2000-01-14

Applicant: LIGHT SCIENCES LTD ,  CHEN JAMES

Inventor： CHEN JAMES

IPC: A61N5/06 ,  A61D7/00 ,  A61K31/197 ,  A61K31/404 ,  A61K31/5415 ,  A61K31/609 ,  A61K39/395 ,  A61K41/00 ,  A61P9/10 ,  A61P35/00 ,  A61P43/00

CPC classification number: A61N5/062 ,  A61B18/1815 ,  A61B2090/378 ,  A61K41/0057 ,  A61K41/0071 ,  A61N5/0601 ,  A61N2005/0602 ,  A61N2005/0604 ,  A61N2005/0609 ,  A61N2005/0651 ,  A61N2005/0659

Abstract: The present invention is drawn to methods and compounds for transcutaneous photodynamic therapy ("PDT") of a target tissue or compositions in a mammalian subject, which includes administering to the subject a therapeutically effective amount of a photosensitizing agent or a photosensitizing agent delivery system or a prodrug, where the photosensitizing agent or photosensitizing agent delivery system or prodrug selectively binds to the target tissue; and irradiating at least a portion of the subject with light at a wavelength absorbed by the photosensitizing agent or if prodrug, by a prodrug product thereof, where the light is provided by a light source, and where the irradiation is at low fluence rate that results in the activation of the photosensitizing agent or prodrug product. These methods of transcutaneous PDT are useful in the treatment of specifically selected target tissues, such as: vascular endothelial tissue; abnormal vascular wall of tumors; tumors of the head and neck; tumors of the gastrointestinal tract; tumors of the liver; tumors of the esophopharyngeal; tumors of the lung; lymphoid tissue; lesions in the vascular system; bone marrow and tissue related to autoimmune disease.

Abstract translation: 本发明涉及用于哺乳动物受试者中的目标组织或组合物的经皮光动力疗法（“PDT”）的方法和化合物，其包括向受试者施用治疗有效量的光敏剂或光敏剂递送系统或 前体药物，其中光敏剂或光敏剂递送系统或前药选择性地结合靶组织; 并且用由光敏剂吸收的波长的光照射至少一部分受试者，或者如果前药，由其前药产物照射，其中光由光源提供，并且其中照射的通量率低，结果 在光敏剂或前药产物的活化中。 这些经皮PDT方法可用于特异性选择的靶组织的治疗，例如：血管内皮组织; 肿瘤血管壁异常; 头部和颈部的肿瘤; 胃肠道肿瘤; 肝脏肿瘤; esophopharyngeal的肿瘤; 肺部肿瘤; 淋巴组织; 血管系统中的病变; 骨髓和与自身免疫疾病有关的组织。

公开(公告)号：WO0041768A8

公开(公告)日：2001-04-05

申请号：PCT/US0000805

申请日：2000-01-14

Applicant: LIGHT SCIENCES LTD ,  CHEN JAMES ,  WILKERSON BRIAN ,  BROWN DAVE ,  HUSTON DARRIN ,  MCQUADE MIKE

Inventor： CHEN JAMES ,  WILKERSON BRIAN ,  BROWN DAVE ,  HUSTON DARRIN ,  MCQUADE MIKE

IPC: A61B18/20 ,  A61B18/22 ,  A61B18/24 ,  A61N5/06

CPC classification number: A61N5/062 ,  A61B2018/2005 ,  A61B2018/2261 ,  A61N5/0601 ,  A61N2005/0645

Abstract: A patient portable photodynamic therapy device securable to a patient includes a lightweight rechargeable battery and a light source, such as an LED or a cold cathode fluorescent (CCF) tube powered thereby. The light source is coupled in light channeling relation to a proximal portion of a biocompatible optical fiber, which includes a distal portion with an optional diffuser that uniformly distributes light as it exits the distal portion. The light channeling between the light source and an optical fiber may be accomplished through any number of lens, including a totally internally reflective (TIR) lens. The distal end of the optical fiber is optionally provided with an anchoring balloon that can be inflated after the optical fiber is properly positioned at a treatment site within a patient's body. The balloon securely lodges the distal portion within the tissue at the treatment site, and is deflated to facilitate the removal of the optical fiber once the treatment is complete.

Abstract translation: 可靠的患者便携式光动力治疗装置包括轻量的可充电电池和光源，例如由此供电的LED或冷阴极荧光（CCF）管。 光源与生物相容性光纤的近端部分以光通道的方式耦合，该光源包括具有任选的扩散器的远端部分，该漫射器在光离开远端部分时均匀分布光。 可以通过任何数量的透镜（包括全内反射（TIR））透镜来实现光源和光纤之间的光通道。 光纤的远端可选地设置有锚定球囊，其可以在光纤被适当地定位在患者体内的治疗部位之后被充气。 球囊在治疗部位牢固地悬挂在组织内的远端部分，并且一旦处理完成就被放气以便于去除光纤。