公开(公告)号：WO2011123678A3

公开(公告)日：2012-01-12

申请号：PCT/US2011030774

申请日：2011-03-31

申请人： ARQULE INC ,  ALI SYED M ,  ASHWELL MARK A ,  KELLEHER EUGENE ,  KOERNER STEFFI ,  LAPIERRE JEAN-MARC ,  LINK JEFFREY S ,  LIU YANBIN ,  MOUSSA MAGDI ,  PALMA ROCIO ,  TANDON MANISH ,  VENSEL DAVID ,  WESTLUND NEIL ,  WU HUI ,  YANG RUI-YANG

发明人： ALI SYED M ,  ASHWELL MARK A ,  KELLEHER EUGENE ,  KOERNER STEFFI ,  LAPIERRE JEAN-MARC ,  LINK JEFFREY S ,  LIU YANBIN ,  MOUSSA MAGDI ,  PALMA ROCIO ,  TANDON MANISH ,  VENSEL DAVID ,  WESTLUND NEIL ,  WU HUI ,  YANG RUI-YANG

IPC分类号： C07D471/14 ,  A61K31/5517 ,  A61P35/00 ,  C07D401/04 ,  C07D405/04 ,  C07D487/04

CPC分类号： C07D471/14 ,  C07D487/04

摘要： The present invention relates to substituted benzo-pyrido-triazolo-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-pyrido-triazolo- diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.

摘要翻译： 本发明涉及取代的苯并吡啶并三唑并二氮杂化合物及其合成方法。 本发明还涉及含有取代的苯并吡啶并三唑并二氮杂化合物的药物组合物和通过将这些化合物或药物组合物给予有需要的受试者来治疗细胞增殖性疾病如癌症的方法。

公开(公告)号：WO2011123678A2

公开(公告)日：2011-10-06

申请号：PCT/US2011/030774

申请日：2011-03-31

申请人： ARQULE, INC. ,  ALI, Syed, M. ,  ASHWELL, Mark, A. ,  KELLEHER, Eugene ,  KOERNER, Steffi ,  LAPIERRE, Jean-Marc ,  LINK, Jeffrey, S. ,  LIU, Yanbin ,  MOUSSA, Magdi ,  PALMA, Rocio ,  TANDON, Manish ,  VENSEL, David ,  WESTLUND, Neil ,  WU, Hui ,  YANG, Rui-Yang

发明人： ALI, Syed, M. ,  ASHWELL, Mark, A. ,  KELLEHER, Eugene ,  KOERNER, Steffi ,  LAPIERRE, Jean-Marc ,  LINK, Jeffrey, S. ,  LIU, Yanbin ,  MOUSSA, Magdi ,  PALMA, Rocio ,  TANDON, Manish ,  VENSEL, David ,  WESTLUND, Neil ,  WU, Hui ,  YANG, Rui-Yang

IPC分类号： C07D471/14 ,  C07D405/04 ,  C07D401/04 ,  C07D487/04 ,  A61K31/5517 ,  A61P35/00

CPC分类号： C07D471/14 ,  C07D487/04

摘要： The present invention relates to substituted benzo-pyrido-triazolo-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-pyrido-triazolo- diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.

摘要翻译： 本发明涉及取代的苯并吡啶并三唑并二氮杂化合物及其合成方法。 本发明还涉及含有取代的苯并吡啶并三唑并二氮杂化合物的药物组合物和通过将这些化合物或药物组合物给予有需要的受试者来治疗细胞增殖性疾病如癌症的方法。

公开(公告)号：WO2011082269A3

公开(公告)日：2011-07-07

申请号：PCT/US2010/062438

申请日：2010-12-29

申请人： ARQULE, INC. ,  YANG, Rui-Yang ,  LINK, Jeffrey, S.

发明人： YANG, Rui-Yang ,  LINK, Jeffrey, S.

IPC分类号： C07D487/14 ,  C07D403/04 ,  A61K31/5517 ,  A61K31/519 ,  A61P35/00

摘要： The present invention relates to substituted benzo-pyrimido-tetrazolo- diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-pyrimido-tetrazolo- diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

公开(公告)号：WO2011082269A2

公开(公告)日：2011-07-07

申请号：PCT/US2010062438

申请日：2010-12-29

申请人： ARQULE INC ,  YANG RUI-YANG ,  LINK JEFFREY S

发明人： YANG RUI-YANG ,  LINK JEFFREY S

CPC分类号： A61K31/551 ,  C07D487/14

摘要： The present invention relates to substituted benzo-pyrimido-tetrazolo- diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-pyrimido-tetrazolo- diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

摘要翻译： 本发明涉及取代的苯并嘧啶 - 四唑并二氮杂化合物和合成这些化合物的方法。 本发明还涉及含有取代的苯并嘧啶 - 四唑并二氮杂化合物的药物组合物和通过将这些化合物和药物组合物给予需要的受试者来治疗细胞增殖性疾病如癌症的方法。

公开(公告)号：WO2010114902A1

公开(公告)日：2010-10-07

申请号：PCT/US2010/029414

申请日：2010-03-31

申请人： ARQULE, INC. ,  LAPIERRE, Jean-Marc ,  YANG, Rui-Yang ,  NAMDEV, Nivedita ,  LINK, Jeffrey, S.

发明人： LAPIERRE, Jean-Marc ,  YANG, Rui-Yang ,  NAMDEV, Nivedita ,  LINK, Jeffrey, S.

IPC分类号： C07D471/14 ,  A61K31/55 ,  A61P35/00

CPC分类号： C07D471/14

摘要： The present invention relates to substituted tetrahydropyrazolo-pyrido-azepine compounds of formula (I) and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof, or a pharmaceutically acceptable salt or ester thereof, wherein: X 1 , X 2 ; and X 3 , together with the two carbon atoms numbered "1" and "2", form a ring selected from (a), (b) and (c).

摘要翻译： 本发明涉及式（I）的取代的四氢吡唑并吡啶并吖庚因化合物及其合成方法。 本发明还涉及含有取代的四氢吡唑并 - 哒嗪化合物的药物组合物和通过将这些化合物和药物组合物给予有需要的受试者或其药学上可接受的盐或酯来治疗细胞增殖性疾病如癌症的方法， 其中：X1，X2; 和X3与“1”和“2”的两个碳原子一起形成选自（a），（b）和（c）的环。