公开(公告)号：WO2004082601A2

公开(公告)日：2004-09-30

申请号：PCT/US2004/006906

申请日：2004-03-05

Applicant: BAYER PHARMACEUTICALS CORPORATION ,  LIVINGSTON, James, N. ,  TSUTSUMI, Manami

Inventor： LIVINGSTON, James, N. ,  TSUTSUMI, Manami

IPC: A61K

CPC classification number: A61K31/421 ,  A61K31/192

Abstract: This invention relates to a method of treating diabetes and diabetes-related disorders. Specifically, the method of the present invention relates to administering a single compound that lowers blood glucose levels, lowers serum triglyceride levels, and increases serum high density lipoproteins (HDL) levels thereby providing a treatment option for individuals afflicted with a metabolic disorder such as diabetes mellitus, insulin resistance, impaired glucose tolerance, and dyslipidemia.

Abstract translation: 本发明涉及一种治疗糖尿病和糖尿病相关疾病的方法。 具体地说，本发明的方法涉及施用降低血糖水平的单一化合物，降低血清甘油三酯水平，并增加血清高密度脂蛋白（HDL）水平，从而为患有代谢障碍的个体（例如糖尿病）提供治疗选择 胰岛素抵抗，葡萄糖耐量异常和血脂异常。

公开(公告)号：WO2003082189A2

公开(公告)日：2003-10-09

申请号：PCT/US2003/008712

申请日：2003-03-21

Applicant: BAYER PHARMACEUTICALS CORPORATION ,  LIANG, Yin ,  ZHU, Jian ,  SWEET, Laurel ,  LIVINGSTON, James, N.

Inventor： LIANG, Yin ,  ZHU, Jian ,  SWEET, Laurel ,  LIVINGSTON, James, N.

IPC: A61K

CPC classification number: C12N5/0676 ,  C12N2502/1323 ,  C12N2503/02 ,  C12N2509/00 ,  G01N2500/10

Abstract: The present invention relates to a method for preparing pseudo islets. In addition, the invention is also directed to methods of treating diabetes and diabetes-related disorders by administering compounds identified by the methods described herein.

Abstract translation: 本发明涉及制备假胰岛的方法。 另外，本发明还涉及通过施用通过本文所述方法鉴定的化合物来治疗糖尿病和糖尿病相关病症的方法。

公开(公告)号：WO2004082601A3

公开(公告)日：2005-03-10

申请号：PCT/US2004006906

申请日：2004-03-05

Applicant: BAYER PHARMACEUTICALS CORP ,  LIVINGSTON JAMES N ,  TSUTSUMI MANAMI

Inventor： LIVINGSTON JAMES N ,  TSUTSUMI MANAMI

IPC: A61K20060101 ,  A61K31/045 ,  A61K31/12

CPC classification number: A61K31/421 ,  A61K31/192

Abstract: This invention relates to a method of treating diabetes and diabetes-related disorders. Specifically, the method of the present invention relates to administering a single compound that lowers blood glucose levels, lowers serum triglyceride levels, and increases serum high density lipoproteins (HDL) levels thereby providing a treatment option for individuals afflicted with a metabolic disorder such as diabetes mellitus, insulin resistance, impaired glucose tolerance, and dyslipidemia.

Abstract translation: 本发明涉及一种治疗糖尿病和糖尿病相关疾病的方法。 具体地说，本发明的方法涉及施用降低血糖水平的单一化合物，降低血清甘油三酯水平，并增加血清高密度脂蛋白（HDL）水平，从而为患有代谢紊乱的个体（例如糖尿病）提供治疗选择 胰岛素抵抗，葡萄糖耐量异常和血脂异常。

公开(公告)号：WO2003082189A3

公开(公告)日：2003-10-09

申请号：PCT/US2003/008712

申请日：2003-03-21

Applicant: BAYER PHARMACEUTICALS CORPORATION ,  LIANG, Yin ,  ZHU, Jian ,  SWEET, Laurel ,  LIVINGSTON, James, N.

Inventor： LIANG, Yin ,  ZHU, Jian ,  SWEET, Laurel ,  LIVINGSTON, James, N.

IPC: C12N5/00

Abstract: The present invention relates to a method for preparing pseudo islets. In addition, the invention is also directed to methods of treating diabetes and diabetes-related disorders by administering compounds identified by the methods described herein.

公开(公告)号：WO2003011842A1

公开(公告)日：2003-02-13

申请号：PCT/US2002/023614

申请日：2002-07-25

Applicant: BAYER CORPORATION ,  LOWE, Derek, B. ,  WICKENS, Philip, L. ,  MA, Xin ,  ZHANG, Mingbao ,  BULLOCK, William, H. ,  COISH, Philip, D.G. ,  MUGGE, Ingo, A. ,  STOLLE, Andreas ,  WANG, Ming ,  WANG, Yamin ,  ZHANG, Chengzhi ,  ZHANG, Hai-Jun ,  ZHU, Lei ,  TSUTSUMI, Manami ,  LIVINGSTON, James, N.

Inventor： LOWE, Derek, B. ,  WICKENS, Philip, L. ,  MA, Xin ,  ZHANG, Mingbao ,  BULLOCK, William, H. ,  COISH, Philip, D.G. ,  MUGGE, Ingo, A. ,  STOLLE, Andreas ,  WANG, Ming ,  WANG, Yamin ,  ZHANG, Chengzhi ,  ZHANG, Hai-Jun ,  ZHU, Lei ,  TSUTSUMI, Manami ,  LIVINGSTON, James, N.

IPC: C07D263/32

CPC classification number: C07D277/32 ,  C07B2200/07 ,  C07C51/412 ,  C07C51/44 ,  C07C59/72 ,  C07C67/303 ,  C07C69/732 ,  C07C69/734 ,  C07C69/738 ,  C07C2602/08 ,  C07D263/32 ,  C07D277/24 ,  C07D277/40 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  Y02P20/582

Abstract: This invention relates to novel indane acetic acid derivatives of formula (I) which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates of formula (II) and (III) of indane acetic derivatives and to methods of preparation.

Abstract translation: 本发明涉及式（I）的新型茚满乙酸衍生物，其可用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病。 本发明还涉及二氢化茚衍生物的式（II）和（III）的中间体和制备方法。