公开(公告)号：WO0040558A8

公开(公告)日：2000-08-31

申请号：PCT/US0000265

申请日：2000-01-06

Applicant: US HEALTH ,  RANDAD RAMNARAYAN S ,  ERICKSON JOHN W ,  EISSENSTAT MICHAEL A ,  LUBKOWSKA LUCYNA

Inventor： RANDAD RAMNARAYAN S ,  ERICKSON JOHN W ,  EISSENSTAT MICHAEL A ,  LUBKOWSKA LUCYNA

IPC: A61P31/18 ,  C07C235/20 ,  C07C235/50 ,  C07C237/34 ,  C07C271/20 ,  C07C271/22 ,  C07C311/29 ,  C07D207/26 ,  C07D207/27 ,  C07D211/60 ,  C07D213/30 ,  C07D215/48 ,  C07D239/10 ,  C07D277/24 ,  C07D295/215 ,  C07D307/20 ,  C07D405/12 ,  C07D417/12 ,  C07D213/56 ,  A61K31/335 ,  A61K31/425 ,  A61K31/44 ,  C07D265/32 ,  C07D277/20 ,  C07D295/16 ,  C07D295/20

CPC classification number: C07D207/27 ,  C07C235/20 ,  C07C235/50 ,  C07C237/34 ,  C07C271/20 ,  C07C271/22 ,  C07C311/29 ,  C07D211/60 ,  C07D213/30 ,  C07D215/48 ,  C07D239/10 ,  C07D277/24 ,  C07D295/215 ,  C07D307/20 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention provides a compound of formula (I) wherein a, b, c, d, and e, are R , OR , SR , NR R , NHCOR , CO2R , CN, NO2, NH2, N3, or a halogen. R and R are H or alkyl, R and R are H or alkyl, and R is a non-aromatic substituent. Substituent A is OH, NH2, or SH. Substituents B and B include amide and sulfonamide groups, which can be cyclic, acyclic, or amino acid derivatives. Alternatively, B and R' together with the nitrogen to which they are bonded, and/or B' and R together with the nitrogen to which they are bonded, define a heterocycle. The present invention further provides a pharmaceutical composition that includes a carrier and a therapeutically effective amount of at least one compound of the present invention. The present invention further provides therapeutic methods that include administering a therapeutically effective amount of at least one compound of the present invention.

Abstract translation: 本发明提供了其中a，b，c，d和e是R 7，OR 7， CO 2 R 7，CN，NO 2，NH 2，N 3或卤素。 R 7和R 8为H或烷基，R 1和R 2为H或烷基，并且R 3为非芳族取代基。 取代基A是OH，NH 2或SH。 取代基B和B 1包括酰胺基和磺酰胺基，其可以是环状，无环或氨基酸衍生物。 或者，B和R'与它们所键合的氮一起和/或B'和R 2与它们所键合的氮一起形成杂环。 本发明还提供了包含载体和治疗有效量的至少一种本发明化合物的药物组合物。 本发明进一步提供了治疗方法，其包括施用治疗有效量的至少一种本发明化合物。