公开(公告)号：WO1995023131A1

公开(公告)日：1995-08-31

申请号：PCT/IE1995000003

申请日：1995-01-09

申请人： SALDANE LIMITED ,  DYATLOV, Valery Alexandrovich ,  MALEEV, Viktor

发明人： SALDANE LIMITED

IPC分类号： C07C255/64

CPC分类号： C07C255/64 ,  C07C253/30

摘要： A process for the preparation of 2-cyanoacrylic acid from poly(alkyl 2-cyanoacrylates), comprises the steps of: a) subjecting oligomeric or polymeric cyanoacrylate material to catalysed pyrolysis in a reactor under polymerisation inhibiting conditions at a temperature greater than 200 DEG C and under conditions sufficient to vaporise the 2-cyanoacrylic acid formed; b) cooling the vapours which emerge from the reactor on completion of the pyrolysis; and c) collecting the 2-cyanoacrylic acid formed. The oligomeric cyanoacrylate or polymeric material can be selected from crude oligomer, purified oligomer, oligomer produced as a by-product in the conversion of crude oligomer to purified oligomer, oligomer produced as a by-product during the depolymerisation of purified oligomer, oligomer produced during the conversion of crude monomer to purified monomer and polymer produced during storage of purified monomer.

摘要翻译： 从聚（2-氰基丙烯酸烷基酯）制备2-氰基丙烯酸的方法包括以下步骤：a）使聚合氰基丙烯酸酯材料在聚合抑制条件下在高于200℃的温度下在反应器中催化裂解 并在足以蒸发形成的2-氰基丙烯酸的条件下进行; b）在完成热解后冷却从反应器中出来的蒸汽; 和c）收集形成的2-氰基丙烯酸。 寡聚氰基丙烯酸酯或聚合物材料可以选自粗制低聚物，纯化的低聚物，低聚物，其作为副产物在将粗寡聚物转化成纯化的寡聚物时产生副产物，在纯化的低聚物的解聚期间作为副产物产生的低聚物， 在纯化的单体储存期间粗制单体转化成纯化的单体和聚合物。

公开(公告)号：WO1996014292A1

公开(公告)日：1996-05-17

申请号：PCT/IE1995000053

申请日：1995-10-18

申请人： SALDANE LIMITED ,  DYATLOV, Valery Alexandrovich ,  MALEEV, Viktor ,  GUSEVA, Tatiana

发明人： SALDANE LIMITED

IPC分类号： C07C253/34

CPC分类号： A61K9/7023 ,  A61K9/0021 ,  A61M5/14244 ,  A61M5/14248 ,  A61M2005/14268 ,  C07C253/34

摘要： A process for purification of non-enolisable esters, especially esters of 2-cyanoacrylic acid, from contaminating volatile acids, non-volatile acids and other substances which can decompose to generate strongly acidic impurities, comprises reacting a solution of the ester with a metallic reagent selected from a metal, metal oxide and a metal hydride or a mixture thereof in the form of a dispersion, emulsion or suspension. The metallic reagent is optionally supported on a solid, insoluble support. The process is especially suitable for the purification of liquid, non-distillable esters of 2-cyanoacrylic acid.

摘要翻译： 用于从污染的挥发性酸，非挥发性酸和可分解产生强酸性杂质的其它物质中纯化非烯醇化酯，特别是2-氰基丙烯酸酯的方法包括使酯的溶液与金属试剂 选自分散体，乳液或悬浮液形式的金属，金属氧化物和金属氢化物或其混合物。 金属试剂任选地负载在固体不溶性载体上。 该方法特别适用于纯化2-氰基丙烯酸的液体，不蒸馏的酯。

公开(公告)号：WO1995032183A1

公开(公告)日：1995-11-30

申请号：PCT/IE1995000017

申请日：1995-02-08

申请人： SALDANE LIMITED ,  DYATLOV, Valery Alexandrovich ,  MALEEV, Viktor

发明人： SALDANE LIMITED

IPC分类号： C07C253/30

CPC分类号： C07C253/30 ,  C07C255/23

摘要： A process for the preparation of 2-cyanoacryloyl chloride in pure form comprises reacting 2-cyanoacrylic acid with a chlorinating agent, said reaction being carried out under side-reaction and polymerisation inhibiting conditions. A preferred chlorinating agent is a volatile chlorinating agent which forms only volatile by-products during the course of the reaction. Suitable volatile chlorinating agents include oxalyl chloride, sulfur oxychloride, trifluoroacetyl chloride and phosgene. Various methods can be used to inhibit polymerisation initiating conditions such as the use of a catalyst which forms an intermediate complex with the chlorinating agent, thereby preventing the formation of a mixed anhydride. The 2-cyanoacryloyl chloride formed can be used to form esters useful in the manufacture of adhesives and which esters are free of contaminants which would otherwise affect the setting time of the adhesives.

摘要翻译： 制备纯形式的2-氰基丙烯酰氯的方法包括使2-氰基丙烯酸与氯化剂反应，所述反应在副反应和聚合抑制条件下进行。 优选的氯化剂是在反应过程中仅形成挥发性副产物的挥发性氯化剂。 合适的挥发性氯化剂包括草酰氯，硫氧氯化物，三氟乙酰氯和光气。 可以使用各种方法抑制聚合引发条件，例如使用与氯化剂形成中间体络合物的催化剂，从而防止混合酸酐的形成。 所形成的2-氰基丙烯酰氯可用于形成用于制备粘合剂的酯，哪些酯不含污染物，否则会影响粘合剂的凝固时间。

公开(公告)号：WO1995026371A1

公开(公告)日：1995-10-05

申请号：PCT/IE1994000018

申请日：1994-03-28

申请人： PATRIQUE LIMITED ,  DYATLOV, Valery Alexandrovich ,  MALEEV, Viktor

发明人： PATRIQUE LIMITED

IPC分类号： C08F22/32

CPC分类号： C08F22/32 ,  C07C253/30 ,  C07C255/19 ,  C07C255/20 ,  C07C323/60 ,  C07F9/4006

摘要： A process is provided for the reversible coupling of weak nucleophiles to the carbon-carbon double bond of 2-cyanoacrylic acid or an ester thereof so as to reversibly protect the bond. Examples of weak nucleophiles include alcohols (including diols and polyols), phenols, sulfur nucleophiles such as thiols and thio acids, phosphorus nucleophiles such as dialkyl or diarylphosphites and phosphines, and carbon nucleophiles such as active methylene compounds. The process involves reacting 2-cyanoacrylic acid or an ester thereof with the weak nucleophile in the presence of an inert solvent under polymerisation inhibiting conditions and in the presence of an acidic catalyst. The compounds produced can be used as intermediates for the preparation of poly(cyanoacrylates), following elimination of the nucleophile added to give a 2-cyanoacrylate monomer which then polymerizes. The poly(cyanoacrylates) thereby produced have many applications, for example, in the preparation of films such as single- or multi-layer Langmuir-Blodgett films.

摘要翻译： 提供了用于弱亲核试剂与2-氰基丙烯酸或其酯的碳 - 碳双键的可逆偶联的方法，以便可逆地保护该键。 弱亲核试剂的实例包括醇（包括二醇和多元醇），酚，硫亲核试剂如硫醇和硫代酸，磷亲核试剂如二烷基或二芳基亚磷酸酯和膦，以及碳亲核试剂如活性亚甲基化合物。 该方法包括在惰性溶剂存在下，在聚合抑制条件下和在酸性催化剂存在下，将2-氰基丙烯酸或其酯与弱亲核试剂反应。 所产生的化合物可以用作制备聚（氰基丙烯酸酯）的中间体，除去加入的亲核试剂后，得到聚合的2-氰基丙烯酸酯单体。 由此制备的聚（氰基丙烯酸酯）具有许多应用，例如在诸如单层或多层Langmuir-Blodgett膜的膜的制备中。