公开(公告)号：WO2011113107A1

公开(公告)日：2011-09-22

申请号：PCT/AU2011/000303

申请日：2011-03-18

Applicant: THE UNIVERSITY OF MELBOURNE ,  HUBBARD, Michael James ,  MANGUM, Jonathan Edward

Inventor： HUBBARD, Michael James ,  MANGUM, Jonathan Edward

IPC: A61K6/00 ,  A61K49/00 ,  A61Q11/00

CPC classification number: A61K6/002 ,  A61B5/4547 ,  A61K49/001 ,  A61K49/006 ,  A61K49/0438 ,  C07K14/00 ,  G01N33/6893

Abstract: The present invention relates to a kit and a probe for detecting porous dental hydroxyapatite, comprising a protein capable of binding porous dental hydroxyapatite or a detector thereof. The invention also relates to a method for detecting a condition involving porous dental hydroxyapatite comprising detecting in or on a tooth or a sample of the tooth of a subject a protein bound to porous dental hydroxyapatite. The invention also relates to methods for detecting a hypomineralisation developmental dental defect or detecting intact and/or broken MIH enamel, and to a kit and method for removing a protein bound to porous dental hydroxyapatite.

Abstract translation: 本发明涉及一种用于检测多孔牙羟基磷灰石的试剂盒和探针，其包含能够结合多孔牙羟基磷灰石的蛋白质或其检测器。 本发明还涉及一种用于检测涉及多孔牙羟基磷灰石的病症的方法，其包括检测受试者的牙齿或牙齿样品中与多孔牙羟基磷灰石结合的蛋白质。 本发明还涉及用于检测低矿化发育牙缺损或检测完整和/或破碎的MIH釉质的方法，以及用于去除结合多孔牙羟磷灰石的蛋白质的试剂盒和方法。