公开(公告)号：WO2014149069A1

公开(公告)日：2014-09-25

申请号：PCT/US2013/056629

申请日：2013-08-26

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： LOW, Philip, S. ,  KULARATNE, Sumith, A. ,  MAHALINGAM, Sakkarapalayam, M.

IPC: A61K31/519 ,  A61K49/00

CPC classification number: A61K49/0052 ,  A61K49/001 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  C07D475/04 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/6893 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2333/705 ,  G01N2800/24

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

Abstract translation: 本公开涉及可用作近红外荧光探针的化合物，其中所述化合物包括i）与靶受体蛋白结合的蝶啶配体，ii）染料分子，和iii）包含氨基酸的连接分子 或其衍生物。 本公开进一步描述了制备和使用化合物的方法和组合物，并入化合物的方法，以及并入化合物的试剂盒。

公开(公告)号：WO2007012004A2

公开(公告)日：2007-01-25

申请号：PCT/US2006028022

申请日：2006-07-19

Applicant: UNIV ILLINOIS ,  HONG CHANG ,  YAMADA TOHRU ,  FIALHO ARSENIO ,  DAS GUPTA TAPAS ,  CHAKRABARTY ANANDA

Inventor： HONG CHANG ,  YAMADA TOHRU ,  FIALHO ARSENIO ,  DAS GUPTA TAPAS ,  CHAKRABARTY ANANDA

IPC: C07K14/195 ,  C07K14/82

CPC classification number: C07K14/22 ,  A61K9/0085 ,  A61K38/00 ,  A61K38/164 ,  A61K45/06 ,  A61K47/64 ,  A61K47/66 ,  A61K49/0002 ,  A61K49/001 ,  A61K49/0041 ,  A61K49/0056 ,  A61K49/04 ,  A61K49/085 ,  A61K49/14 ,  A61K49/221 ,  B82Y5/00 ,  C07K7/06 ,  C07K14/47 ,  C12N15/625 ,  G01N33/5091

Abstract: The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer.

Abstract translation: 本发明公开了将货物化合物输送到脑癌细胞和/或血脑屏障的方法和材料。 通过使用衍生自奈瑟球菌外膜蛋白质的蛋白质转运肽（例如Laz）来实现货物化合物的递送。 本发明还提供了由五肽AAEAP组成的合成转运肽。 本发明还公开了用于治疗癌症，特别是脑癌以及其他脑相关病症的方法。 此外，本发明提供了成像和诊断癌症，特定脑癌的方法。

公开(公告)号：WO1990015059A1

公开(公告)日：1990-12-13

申请号：PCT/CA1990000191

申请日：1990-06-07

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA

Inventor： THE UNIVERSITY OF BRITISH COLUMBIA ,  DOLPHIN, David ,  HIN, Paul, Yon ,  WIJESEKERA, Tilak

IPC: C07D487/22

CPC classification number: C07D487/22 ,  A61K41/0071 ,  A61K47/60 ,  A61K49/001

Abstract: A group of hydro-dibenzoporphyrins for example (I) prepared by di-Diels-Alder additions at the A and C or B and D rings of the appropriate divinyl porphyrins have absorption maxima in the range of 700-820 nanometers and are photosensitizing agents. These compounds are useful in treating disorders or conditions which are subject to hematoporphyrin derivative (HPD) treatment in the presence of light, or in treating biological materials generally to destroy unwanted targets such as viruses, cells and tissues. The use of the compounds of the invention permits irradiation with wavelengths other than those absorbed by blood. The compounds of the invention may also be conjugated to ligands specific for receptors or to specific immunoglobulins or fragments thereof to home to target tissues or cells for the radiation treatment. Use of these materials permits lower levels of photosensitizer to be used, thus preventing side reactions which might destroy normal tissues.

Abstract translation: 在适当的二乙烯基卟啉的A和C或B和D环上通过二狄尔斯 - 阿尔德添加剂制备的一组氢 - 二苯并卟啉的吸收最大值在700-820纳米范围内，并且是光敏剂。 这些化合物可用于治疗在光存在下经受血卟啉衍生物（HPD）治疗的病症或病症，或通常用于治疗生物材料以破坏不想要的靶，例如病毒，细胞和组织。 使用本发明的化合物允许用除了被血液吸收的那些以外的波长的照射。 本发明的化合物还可以与受体特异性配体或特异性免疫球蛋白或其片段缀合到用于放射治疗的靶组织或细胞的家中。 使用这些材料可以使用较低水平的光敏剂，从而防止可能破坏正常组织的副反应。

公开(公告)号：WO2017176380A1

公开(公告)日：2017-10-12

申请号：PCT/US2017/018874

申请日：2017-02-22

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： ANDERSON, Richard, Rox ,  LEVIN, Yakir

IPC: A61B18/20 ,  A61K41/00 ,  A61N5/06

CPC classification number: A61B18/203 ,  A61B5/0071 ,  A61B90/361 ,  A61B2017/00061 ,  A61B2018/00458 ,  A61B2018/00476 ,  A61B2018/00577 ,  A61B2018/00625 ,  A61B2018/00642 ,  A61B2018/00672 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00785 ,  A61B2018/00904 ,  A61K49/001 ,  A61K49/0021

Abstract: Systems and methods are provided for locating anatomical features in the skin based on analysis of reflected light, and treating the located anatomical features using high-energy light. A labeling agent can be administered to optically differentiate the anatomical feature.

Abstract translation: 提供了系统和方法，用于基于反射光的分析来定位皮肤中的解剖特征，并且使用高能量光来处理定位的解剖特征。 可以给予标记剂以光学区分解剖特征。

公开(公告)号：WO2016187141A1

公开(公告)日：2016-11-24

申请号：PCT/US2016/032749

申请日：2016-05-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： SRINIVASAN, Vivek J. ,  MERKLE, Conrad

IPC: G01B9/00 ,  G01B9/02

CPC classification number: A61B5/0066 ,  A61B3/102 ,  A61B5/0261 ,  A61K49/001

Abstract: The disclosed embodiments relate to analyzing tissue samples. A contrast agent can be administered to an animal or human, thereby causing the contrast agent to move through a field-of-view in a tissue sample in the animal or human. Next, the field-of-view can be repeatedly imaged in the tissue sample using, e.g., optical coherence tomography (OCT). The one or more images can then be used to analyze the movement of the contrast agent through the tissue sample. In some embodiments, the contrast agent is endogenously derived from the animal or human to which or whom it is administered, thereby ensuring that the contrast agent is fully biocompatible and non-immunogenic with respect to the animal or human.

Abstract translation: 所公开的实施例涉及分析组织样本。 可以对动物或人施用造影剂，从而使造影剂通过动物或人体的组织样本中的视场移动。 接下来，可以使用例如光学相干断层摄影（OCT）在组织样本中重复地成像视野。 然后可以使用一个或多个图像来分析造影剂通过组织样本的运动。 在一些实施方案中，造影剂是内源性衍生自施用于其或由其施用的动物或人，从而确保造影剂相对于动物或人完全生物相容性且不具有免疫原性。

公开(公告)号：WO2014186878A1

公开(公告)日：2014-11-27

申请号：PCT/CA2014/000458

申请日：2014-05-26

Applicant: CASHMAN, Neil R.

Inventor： CASHMAN, Neil R.

IPC: A61K39/395 ,  A61K47/48 ,  A61K49/00 ,  A61P25/00 ,  G01N33/566

CPC classification number: C07K16/2878 ,  A61K39/0005 ,  A61K47/48561 ,  A61K47/6849 ,  A61K49/001 ,  A61K2039/55566 ,  C07K16/2872 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/6893 ,  G01N2333/70578

Abstract: Provided are methods and agents for depleting senescent cells endogenous to a subject, involving administering to the subject a binding agent that is selectively toxic to senescent cells in an amount effective to reduce the number of such cells, wherein the binding agent binds selectively to a senescent cell surface protein having a misfolded conformation, relative to said protein in a native conformation.

Abstract translation: 提供了用于消耗受试者内源性的衰老细胞的方法和试剂，包括向受试者施用以有效减少这种细胞数目的量对衰老细胞有选择性毒性的结合剂，其中所述结合剂选择性结合衰老 相对于天然构象中的所述蛋白质，细胞表面蛋白具有错折叠构象。

公开(公告)号：WO2012001063A1

公开(公告)日：2012-01-05

申请号：PCT/EP2011/060936

申请日：2011-06-29

Applicant: GE HEALTHCARE AS ,  MOKKAPATI, Umamaheshwar, P

Inventor： MOKKAPATI, Umamaheshwar, P

IPC: C09B67/22 ,  G01N33/533 ,  G01N33/58

CPC classification number: C09B23/083 ,  A61K49/001 ,  C07D209/14 ,  C09B23/0091 ,  C09B57/00 ,  C09B67/0034 ,  G01N33/583

Abstract: The present invention relates to sulfonated unsymmetrical pentamethine optical dye compositions, especially dyes suitable for biological applications in vitro , and for in vivo imaging. Improved dye compositions and intermediates are provided, which enable the suppression of undesirable newly-identified impurities. Also provided is the use of the improved dye compositions in the preparation of conjugates with biological targeting molecules.

Abstract translation: 本发明涉及磺化非对称五甲基酞菁光学染料组合物，特别是适用于体外生物应用的染料和用于体内成像的染料。 提供改进的染料组合物和中间体，其能够抑制不期望的新鉴定的杂质。 还提供了改进的染料组合物在与生物靶向分子的共轭物的制备中的用途。

公开(公告)号：WO2011122947A1

公开(公告)日：2011-10-06

申请号：PCT/NL2011/050218

申请日：2011-04-01

Applicant: MEDICAL TECHNOLOGY TRANSFER HOLDING B.V. ,  MELLES, Gerrit Reinold Jacob

Inventor： MELLES, Gerrit Reinold Jacob

IPC: A61K49/00 ,  A61K45/06

CPC classification number: A61K49/001 ,  A61K9/0048 ,  A61K49/0023 ,  A61K49/0028 ,  A61K49/003 ,  A61K49/0034 ,  A61K49/006 ,  A61K49/0071

Abstract: The invention is directed to a staining composition and to the use of the staining composition in staining ocular tissue. In a first aspect, the invention provides a staining composition comprising a vital dye and a density increasing compound chosen from the group consisting of water soluble polymers and small inert molecules.

Abstract translation: 本发明涉及染色组合物以及染色组合物在染色眼组织中的用途。 在第一方面，本发明提供一种染色组合物，其包含活性染料和选自水溶性聚合物和小惰性分子的密度增加化合物。

公开(公告)号：WO2008067079A2

公开(公告)日：2008-06-05

申请号：PCT/US2007/082146

申请日：2007-10-22

Applicant: CARDIOSPECTRA, INC. ,  BOARD OF REGENTS, THE TEXAS UNIVERSITY SYSTEM ,  CASTELLA, Paul ,  KIM, Jihoon

Inventor： CASTELLA, Paul ,  KIM, Jihoon

IPC: A61B5/055 ,  A61B6/00 ,  A61K49/00 ,  A61P9/00

CPC classification number: A61B5/416 ,  A61B5/01 ,  A61K49/001 ,  B82Y15/00

Abstract: Provided herein are systems, methods, and compositions for the thermal imaging of cells with nanoparticles.

Abstract translation: 本文提供的是具有纳米颗粒的细胞的热成像的系统，方法和组合物。

公开(公告)号：WO2004091386A3

公开(公告)日：2005-03-17

申请号：PCT/IB2004050443

申请日：2004-04-15

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  GLEICH BERNHARD

Inventor： GLEICH BERNHARD

IPC: A61B5/00 ,  A61B5/05 ,  A61B5/06 ,  A61K49/18

CPC classification number: A61B5/05 ,  A61B5/0515 ,  A61K49/0002 ,  A61K49/001 ,  A61K49/1818

Abstract: The present invention relates to a method for the spatially resolved determination of mechanical, physical, chemical and/or biological properties or state variables and/or the change in mechanical, physical, chemical and/or biological properties or state variables in an examination area of an examination object by means of the following steps: a) introducing magnetic particles into the examination area, b) generating a magnetic field with first part-area having a low magnetic field strength and a second part-area having a higher magnetic field strength, c) generating a superposed oscillating or rotating magnetic field in the first part-area, so that at least some of these magnetic particles oscillate or rotate, d) irradiating electromagnetic radiation into the examination area and e) detecting the reflected and/or scattered electromagnetic radiation and determining the intensity, absorption and/or polarization. The invention furthermore relates to a device for carrying out the method. The invention further relates to an optical contrast compositions and a magnetic particle composition having improved imaging properties.

Abstract translation: 本发明涉及一种用于空间分辨确定机械，物理，化学和/或生物学特性或状态变量的方法和/或在检查区域的机械，物理，化学和/或生物学特性或状态变量的变化 通过以下步骤进行检查对象：a）将磁性粒子引入检查区域，b）产生具有低磁场强度的第一部分区域和具有较高磁场强度的第二部分区域的磁场， c）在所述第一部分区域中产生叠加的振荡或旋转磁场，使得这些磁性颗粒中的至少一些振荡或旋转，d）将电磁辐射照射到检查区域中，以及e）检测反射和/或散射电磁 辐射并确定强度，吸收和/或极化。 本发明还涉及一种用于执行该方法的装置。 本发明还涉及具有改进的成像性质的光学对比组合物和磁性颗粒组合物。