公开(公告)号：WO2005009285A9

公开(公告)日：2005-02-03

申请号：PCT/US2004/023211

申请日：2004-07-20

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  HERRMANN, Howard, C. ,  MANKAME, Nilesh ,  ANANTHASURESH, Suresh, G., K.

Inventor： HERRMANN, Howard, C. ,  MANKAME, Nilesh ,  ANANTHASURESH, Suresh, G., K.

IPC: A61F2/24

Abstract: A percutaneously inserted bistable heart valve prosthesis (10) is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve (10) has an annular ring (12), a body member (14) having a plurality of legs (16), each leg (16) connecting at one end to the annular ring (12), claws (18) that are adjustable from a first position to a second position by application of external force so as to allow ingress of surrounding heart tissue into the claws (18) in the second position, and leaflet membranes connected to the annular ring (12), the body member (14) and/or the legs (16), the leaflet membranes having a first position for blocking blood flow therethrough and a second position for allowing blood flow therethrough. The heart valve (10) is designed such that upon removal of the external force the claws (18) elastically revert to the first position so as to grip the heart tissue positioned within the claws (18), thereby holding the heart valve (10) in place.. The heart valve (10) may be used as a prosthesis for the mitral valve, aortic valve, pulmonary valve, or tricuspid valve by adapting the annular ring to fit in a respective mitral, aortic, pulmonary, or tricuspid valve opening of the heart.

公开(公告)号：WO2020205508A1

公开(公告)日：2020-10-08

申请号：PCT/US2020/025197

申请日：2020-03-27

Applicant: PURDUE RESEARCH FOUNDATION ,  ZAVATTIERI, Pablo ,  ZHANG, Yunlan ,  MANKAME, Nilesh ,  RESTREPO, David ,  JARROLD, Gordon ,  VELAY-LIZANCOS, Maria Mirian

Inventor： ZAVATTIERI, Pablo ,  ZHANG, Yunlan ,  MANKAME, Nilesh ,  RESTREPO, David ,  JARROLD, Gordon ,  VELAY-LIZANCOS, Maria Mirian

IPC: F03G7/06 ,  B32B3/10 ,  B32B3/12 ,  B32B3/26 ,  B32B3/28 ,  C22F1/00 ,  F03G7/00

Abstract: A phase transformational cellular material, including a plurality of bistable cells, each respective bistable cell operationally connected to at least one other respective bistable cell. Each bistable cell enjoys a first stable phase and a second stable phase. The first stable phase is a first geometric configuration and the second stable phase is a second geometric configuration different from the first geometric configuration. An energy transaction is required to shift each respective cell between stable phases. A mechanical energy transaction is required to shift from the first to the second phase, while a thermal energy transaction is required to shift from the second to the first phase.

公开(公告)号：WO2005009285A3

公开(公告)日：2005-05-06

申请号：PCT/US2004023211

申请日：2004-07-20

Applicant: UNIV PENNSYLVANIA ,  HERRMANN HOWARD C ,  MANKAME NILESH ,  ANANTHASURESH SURESH G K

Inventor： HERRMANN HOWARD C ,  MANKAME NILESH ,  ANANTHASURESH SURESH G K

IPC: A61F20060101 ,  A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/243 ,  Y10S623/904

Abstract: A percutaneously inserted bistable heart valve prosthesis (10) is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve (10) has an annular ring (12), a body member (14) having a plurality of legs (16), each leg (16) connecting at one end to the annular ring (12), claws (18) that are adjustable from a first position to a second position by application of external force so as to allow ingress of surrounding heart tissue into the claws (18) in the second position, and leaflet membranes connected to the annular ring (12), the body member (14) and/or the legs (16), the leaflet membranes having a first position for blocking blood flow therethrough and a second position for allowing blood flow therethrough. The heart valve (10) is designed such that upon removal of the external force the claws (18) elastically revert to the first position so as to grip the heart tissue positioned within the claws (18), thereby holding the heart valve (10) in place.. The heart valve (10) may be used as a prosthesis for the mitral valve, aortic valve, pulmonary valve, or tricuspid valve by adapting the annular ring to fit in a respective mitral, aortic, pulmonary, or tricuspid valve opening of the heart.

Abstract translation: 经皮插入的双稳态心脏瓣膜假体（10）折叠在导管内，用于经心脏输送到患者的心脏以进行植入。 心脏瓣膜（10）具有环形环（12），具有多个腿部（16）的主体构件（14），每个腿部（16）在一端连接到环形环（12），爪（18） 其可通过施加外力从第一位置调节到第二位置，以便允许周围心脏组织进入第二位置的爪（18），以及连接到环形环（12）的小叶膜，身体 构件（14）和/或腿部（16），所述小叶膜具有用于阻止血液流过其中的第一位置和用于允许血液流过其中的第二位置。 心脏瓣膜（10）被设计成使得在去除外力时，爪（18）弹性回复到第一位置，以便夹紧位于爪（18）内的心脏组织，从而保持心脏瓣膜（10） 心脏瓣膜（10）可以用作二尖瓣，主动脉瓣，肺动脉瓣或三尖瓣的假体，通过使环形圈适应于相应的二尖瓣，主动脉，肺或三尖瓣开口 的心脏。

公开(公告)号：WO2005009285A2

公开(公告)日：2005-02-03

申请号：PCT/US2004023211

申请日：2004-07-20

Applicant: UNIV PENNSYLVANIA ,  HERRMANN HOWARD C ,  MANKAME NILESH ,  ANANTHASURESH SURESH G K

Inventor： HERRMANN HOWARD C ,  MANKAME NILESH ,  ANANTHASURESH SURESH G K

IPC: A61F20060101 ,  A61F2/24 ,  A61F

CPC classification number: A61F2/2412 ,  A61F2/243 ,  Y10S623/904

Abstract: A percutaneously inserted bistable heart valve prosthesis is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve has an annular ring, a body member having a plurality of legs, each leg connecting at one end to the annular ring, claws that are adjustable from a first position to a second position by application of external force so as to allow ingress of surrounding heart tissue into the claws in the second position, and leaflet membranes connected to the annular ring, the body member and/or the legs, the leaflet membranes having a first position for blocking blood flow therethrough and a second position for allowing blood flow therethrough. The heart valve is designed such that upon removal of the external force the claws elastically revert to the first position so as to grip the heart tissue positioned within the claws, thereby holding the heart valve in place. The body member and claws may be integrated into a one-piece design. The heart valve may be used as a prosthesis for the mitral valve, aortic valve, pulmonary valve, or tricuspid valve by adapting the annular ring to fit in a respective mitral, aortic, pulmonary, or tricuspid valve opening of the heart.

Abstract translation: 经皮插入的双稳态心脏瓣膜假体折叠在导管内，用于经口输送到患者的心脏用于植入。 心脏瓣膜具有环形环，主体部件具有多个腿部，每个腿部在一端连接到环形环上，爪部通过施加外力从第一位置到第二位置可调节以允许进入 周围的心脏组织进入第二位置的爪，以及连接到环形环，身体构件和/或腿的小叶膜，小叶膜具有用于阻止血液流过的第一位置和用于允许血液流动的第二位置 穿过。 心脏瓣膜被设计成使得在去除外力时，爪弹性地恢复到第一位置，以便夹住位于爪内的心脏组织，从而将心脏瓣膜保持在适当的位置。 主体构件和爪可以集成成一体式设计。 心脏瓣膜可用作二尖瓣，主动脉瓣，肺动脉瓣或三尖瓣的假体，通过使环形圈适应于心脏的相应二尖瓣，主动脉，肺或三尖瓣开口。