公开(公告)号：WO2012027583A2

公开(公告)日：2012-03-01

申请号：PCT/US2011/049170

申请日：2011-08-25

Applicant: CHARM SCIENCES, INC. ,  MARKOVSKY, Robert, J. ,  CHARM, Stanley, E. ,  GRAHAM, Paul, E. ,  SKIFFINGTON, Richard, T.

Inventor： MARKOVSKY, Robert, J. ,  CHARM, Stanley, E. ,  GRAHAM, Paul, E. ,  SKIFFINGTON, Richard, T.

IPC: G01N21/31

CPC classification number: G01N21/75 ,  G01N21/78 ,  G01N21/8483 ,  G01N2201/0627

Abstract: Lateral flow assay analysis is shown and described. In one embodiment, the lateral flow assay comprises a surface having a reflectance profile that is adapted to enable monitoring of the assay continuously until the detection of an analyte. In other embodiments, a lateral flow assay system includes an incubator and a reader, wherein the incubator incubates the assay concurrently as the reader generates a test result. Further, an assay measurement apparatus may include an optical detector to perform continuous image detection of the assay to generate a diagnostic test result.

Abstract translation: 显示并描述了横向流动分析分析。 在一个实施例中，横向流动测定包括具有反射率分布的表面，该表面适于连续监测分析，直到检测到分析物。 在其他实施例中，横向流动测定系统包括培养箱和读取器，其中，当读取器生成测试结果时，培养箱同时孵育测定。 此外，化验测量装置可以包括光学检测器以执行化验的连续图像检测以产生诊断测试结果。

公开(公告)号：WO2010151485A1

公开(公告)日：2010-12-29

申请号：PCT/US2010/039113

申请日：2010-06-18

Applicant: CHARM SCIENCES, INC. ,  DOUGLAS, David, W. ,  MARKOVSKY, Robert, J.

Inventor： DOUGLAS, David, W. ,  MARKOVSKY, Robert, J.

IPC: G01N33/53 ,  G01N33/558

CPC classification number: G01N33/552 ,  G01N33/54306 ,  G01N33/9446

Abstract: A method, test strip and method of manufacturing a test strip useful for detecting one or more analytes, such as an antibiotic, in a test sample such as a milk sample. The test strip and method include a labeled specific binder and test capture agent for the specific binder that increases test sensitivity to the analyte for which the specific binder has affinity while decreasing test sensitivity to an analyte for which a multianalyte binder has affinity.

Abstract translation: 用于在测试样品例如牛奶样品中检测一种或多种分析物（例如抗生素）的方法，测试条和制造测试条的方法。 测试条和方法包括标记的特异性粘合剂和用于特定粘合剂的测试捕获剂，其增加对特定粘合剂具有亲和力的分析物的测试敏感性，同时降低对多分析物粘合剂具有亲和力的分析物的测试敏感性。

公开(公告)号：WO2008137095A1

公开(公告)日：2008-11-13

申请号：PCT/US2008/005710

申请日：2008-05-02

Applicant: CHARM SCIENCES, INC. ,  MARKOVSKY, Robert, J.

Inventor： MARKOVSKY, Robert, J.

IPC: A61B1/06

CPC classification number: G01N21/645 ,  A61B1/00057 ,  A61B1/00142 ,  A61B2090/701 ,  A61B2090/702 ,  B01L3/5029 ,  B01L2200/025 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/069 ,  G01N21/76 ,  G01N2001/028

Abstract: A test device configured for obtaining a sample from within a tube such as the one or more channels of an endoscope. The device can include an elongate sample probe and light blocking material.

Abstract translation: 一种被配置为从诸如内窥镜的一个或多个通道的管内获取样品的测试装置。 该装置可以包括细长的样品探针和遮光材料。

公开(公告)号：WO2006089027A2

公开(公告)日：2006-08-24

申请号：PCT/US2006005484

申请日：2006-02-16

Applicant: CHARM SCIENCES INC ,  SAUL STEVEN J ,  TESS MARK E ,  MARKOVSKY ROBERT J

Inventor： SAUL STEVEN J ,  TESS MARK E ,  MARKOVSKY ROBERT J

IPC: G01N33/558

CPC classification number: G01N33/558 ,  Y10S435/97 ,  Y10S436/81

Abstract: A method and device for detecting analytes in a test sample. Embodiments include methods for quantitatively detecting analytes within a range of concentrations. In an embodiment the method includes a lateral flow test strip with multiple test areas for capturing a labeled receptor to provide a detectable signal.

Abstract translation: 一种检测试样中分析物的方法和装置。 实施方案包括用于定量检测浓度范围内的分析物的方法。 在一个实施方案中，该方法包括具有用于捕获标记的受体以提供可检测信号的多个测试区域的侧流测试条。

公开(公告)号：WO2012027583A3

公开(公告)日：2012-08-02

申请号：PCT/US2011049170

申请日：2011-08-25

Applicant: CHARM SCIENCES INC ,  MARKOVSKY ROBERT J ,  CHARM STANLEY E ,  GRAHAM PAUL E ,  SKIFFINGTON RICHARD T

Inventor： MARKOVSKY ROBERT J ,  CHARM STANLEY E ,  GRAHAM PAUL E ,  SKIFFINGTON RICHARD T

IPC: G01N1/00

CPC classification number: G01N21/75 ,  G01N21/78 ,  G01N21/8483 ,  G01N2201/0627

Abstract: Lateral flow assay analysis is shown and described. In one embodiment, the lateral flow assay comprises a surface having a reflectance profile that is adapted to enable monitoring of the assay continuously until the detection of an analyte. In other embodiments, a lateral flow assay system includes an incubator and a reader, wherein the incubator incubates the assay concurrently as the reader generates a test result. Further, an assay measurement apparatus may include an optical detector to perform continuous image detection of the assay to generate a diagnostic test result.

Abstract translation: 显示和描述侧流测定分析。 在一个实施方案中，侧向流动测定包括具有反射率分布的表面，其适于使得能够连续监测分析物直到检测到分析物。 在其它实施方案中，侧流测定系统包括培养箱和读数器，其中培养箱在读取器生成测试结果时同时孵育测定。 此外，测定测量装置可以包括光学检测器，以执行测定的连续图像检测以产生诊断测试结果。

公开(公告)号：WO2008045121A8

公开(公告)日：2008-05-29

申请号：PCT/US2007001229

申请日：2007-01-16

Applicant: CHARM SCIENCES INC ,  CHARM STANLEY E ,  LEGG DAVID R ,  SKIFFINGTON RICHARD T ,  MARKOVSKY ROBERT J

Inventor： CHARM STANLEY E ,  LEGG DAVID R ,  SKIFFINGTON RICHARD T ,  MARKOVSKY ROBERT J

IPC: G01N1/10 ,  C12M1/34 ,  G01N21/00

CPC classification number: G01N21/76 ,  G01N2001/028

Abstract: This application involves detecting luminescence. Various methods and devices are described that reduce interference of ambient light, including UV radiation, on test results. Such methods and devices include using UV blocking material and covering test components prior to use.

Abstract translation: 该应用涉及检测发光。 描述了减少包括紫外线辐射在内的环境光的干扰的各种方法和装置。 这些方法和装置包括在使用之前使用UV阻挡材料并覆盖测试组件。

公开(公告)号：WO0210708A3

公开(公告)日：2003-08-28

申请号：PCT/US0124054

申请日：2001-08-01

Applicant: CHARM SCIENCES INC ,  SAUL STEVEN J ,  BOYER CHERYL A ,  MARKOVSKY ROBERT J ,  SALTER ROBERT S ,  CHARM STANLEY E

Inventor： SAUL STEVEN J ,  BOYER CHERYL A ,  MARKOVSKY ROBERT J ,  SALTER ROBERT S ,  CHARM STANLEY E

IPC: C12Q1/22 ,  C12Q1/34 ,  C12Q1/42 ,  C12Q1/48 ,  C12Q1/04 ,  C12Q1/54 ,  G01N21/00 ,  G01N31/22

CPC classification number: C12Q1/22 ,  C12Q1/34 ,  C12Q1/42 ,  C12Q1/48 ,  C12Q1/54 ,  G01N33/523

Abstract: A test method and test device for hygiene monitoring of a test sample from a biological material or a surface with a biological material to detect the presence of phosphate and glucose as a measure of hygiene by employing a swab-type, puncturable-membrane test apparatus or a lateral-flow or capillary-flow test apparatus.

Abstract translation: 一种生物材料或具有生物材料表面的测试样品的卫生监测的测试方法和测试装置，通过采用拭子型可穿刺膜测试装置或者通过使用棉签式可穿刺膜测试装置或者 侧流或毛细流动测试装置。

公开(公告)号：WO2008045121A1

公开(公告)日：2008-04-17

申请号：PCT/US2007/001229

申请日：2007-01-16

Applicant: CHARM SCIENCES, INC. ,  CHARM, Stanley, E. ,  LEGG, David, R. ,  SKIFFINGTON, Richard, T. ,  MARKOVSKY, Robert, J.

Inventor： CHARM, Stanley, E. ,  LEGG, David, R. ,  SKIFFINGTON, Richard, T. ,  MARKOVSKY, Robert, J.

IPC: G01N1/10 ,  G01N21/00 ,  C12M1/34

CPC classification number: G01N21/76 ,  G01N2001/028

Abstract: This application involves detecting luminescence. Various methods and devices are described that reduce interference of ambient light, including UV radiation, on test results. Such methods and devices include using UV blocking material and covering test components prior to use.

Abstract translation:

这个应用涉及检测发光。 描述了减少环境光（包括UV辐射）对测试结果的干扰的各种方法和设备。 这种方法和设备包括使用紫外线阻挡材料并覆盖测试组件。

公开(公告)号：WO2006089027A3

公开(公告)日：2006-08-24

申请号：PCT/US2006/005484

申请日：2006-02-16

Applicant: CHARM SCIENCES, INC. ,  SAUL, Steven, J. ,  TESS, Mark, E. ,  MARKOVSKY, Robert, J.

Inventor： SAUL, Steven, J. ,  TESS, Mark, E. ,  MARKOVSKY, Robert, J.

IPC: G01N33/53

Abstract: A method and device for detecting analytes in a test sample. Embodiments include methods for quantitatively detecting analytes within a range of concentrations. In an embodiment the method includes a lateral flow test strip with multiple test areas for capturing a labeled receptor to provide a detectable signal.