公开(公告)号：WO2011076883A1

公开(公告)日：2011-06-30

申请号：PCT/EP2010/070568

申请日：2010-12-22

Applicant: 4-ANTIBODY AG ,  FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG ,  GRAWUNDER, Ulf ,  MACH, Michael ,  MARTIN-PARRAS, Luis ,  PÖTZSCH, Sonja ,  SPINDLER, Nadja ,  STICHT, Heinrich ,  WIEGERS, Anna-Katharina ,  WINKLER, Thomas

Inventor： GRAWUNDER, Ulf ,  MACH, Michael ,  MARTIN-PARRAS, Luis ,  PÖTZSCH, Sonja ,  SPINDLER, Nadja ,  STICHT, Heinrich ,  WIEGERS, Anna-Katharina ,  WINKLER, Thomas

IPC: C07K16/08

CPC classification number: C07K16/088 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to binding members, especially antibody molecules, which neutralise the biological effects of human cytomegalovirus (hCMV). The binding members are useful for the treatment and prophylaxis of hCMV infection.

Abstract translation: 本发明涉及中和人巨细胞病毒（hCMV）的生物学作用的结合成员，特别是抗体分子。 结合成员可用于治疗和预防hCMV感染。

公开(公告)号：WO0055364A3

公开(公告)日：2001-10-11

申请号：PCT/GB0000916

申请日：2000-03-10

Applicant: AMERSHAM PHARM BIOTECH UK LTD ,  REEVE MICHAEL ALAN ,  WORKMAN NICHOLAS IAN ,  MARTIN PARRAS LUIS

Inventor： REEVE MICHAEL ALAN ,  WORKMAN NICHOLAS IAN ,  MARTIN-PARRAS LUIS

IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  G01N1/28 ,  G01N33/566 ,  G01N37/00

CPC classification number: C12Q1/683 ,  C12Q1/6837

Abstract: A method is described for use in whole genome analysis. The method - termed inter-population perfectly matched duplex depletion - can overcome many of the limitations of current approaches based upon SNPs and linkage disequilibrium within isolated populations. Inter-population perfectly matched duplex depletion isolates a fragment (or fragments) containing differences between the "affected" and "unaffected" populations or cells. A convenient method - terminal restriction site profiling arrays (TRSPAs) - is described for the analysis of such fragments. A totally diagnostic internal control DNA is also described which allows both the extent and exact nature of any partial digestion to be unambiguously determined for inter-population perfectly matched duplex depletion or TRSPA restriction.

Abstract translation: 描述了用于全基因组分析的方法。 该方法 - 称为群体间完全匹配的双相消耗 - 可以克服基于孤立群体内的SNP和连锁不平衡的当前方法的许多限制。 种群间完全匹配的双相缺失分离了包含“受影响”和“未受影响”群体或细胞之间差异的片段（或片段）。 描述了一种方便的方法 - 终端限制性位点分析阵列（TRSPAs），用于分析这些片段。 还描述了完全诊断的内部对照DNA，其允许明确地确定任何部分消化的程度和确切性质，用于群体间完美匹配的双相消耗或TRSPA限制。