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公开(公告)号：WO2008008224A3
公开(公告)日：2008-06-12
申请号：PCT/US2007015288
申请日：2007-07-10
Applicant: UNIV DUKE , MATSUNAMI HIROAKI , MATSUNAMI MOMOKA , ISHIMARU YOSHIRO
Inventor： MATSUNAMI HIROAKI , MATSUNAMI MOMOKA , ISHIMARU YOSHIRO
CPC classification number: G01N33/566
Abstract: The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste receptor protein mutations that are associated with disease states, and therapeutic agents, ligands, and modulators of such proteins. The present invention also provides compositions and methods for modulating sour taste receptors in vitro and in vivo.
Abstract translation: 本发明涉及酸味受体及其组合物和方法。 特别地，本发明提供了筛选对酸味受体特异性的配体的测定和方法。 此外，本发明提供了用于筛选与疾病状态相关的辅助蛋白质和突变，多态性和其它潜在的酸味受体蛋白质突变的方法，以及这些蛋白质的治疗剂，配体和调节剂。 本发明还提供了体外和体内调节酸味受体的组合物和方法。
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公开(公告)号：WO2006002161A3
公开(公告)日：2006-01-05
申请号：PCT/US2005/021921
申请日：2005-06-20
Applicant: DUKE UNIVERSITY , MATSUNAMI, Hiroaki , MATSUNAMI, Momoka , SAITO, Harumi , ZHUANG, Hanyi
Inventor： MATSUNAMI, Hiroaki , MATSUNAMI, Momoka , SAITO, Harumi , ZHUANG, Hanyi
IPC: C12N15/12 , C12N15/62 , C12Q1/68 , G01N33/567
Abstract: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.
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Patent Agency Ranking
公开(公告)号：WO2011069156A2
公开(公告)日：2011-06-09
申请号：PCT/US2010/059093
申请日：2010-12-06
Applicant: DUKE UNIVERSITY , MATSUNAMI, Hiroaki , LI, Yun
Inventor： MATSUNAMI, Hiroaki , LI, Yun
IPC: C12Q1/68
CPC classification number: C12Q1/6881 , C07K14/70571 , C12Q2600/136 , C12Q2600/156
Abstract: The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine receptor M3) capable of enhancing odorant receptor activation. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for polypeptide polymorphisms and mutations associated with odorant receptor activation (e.g., polymorphisms and mutations associated with muscarinic actetylcholine receptor polypeptides (e.g., M1, M2, M3, M4, M5)), as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.
Abstract translation: 本发明涉及能够调节气味受体活化的多肽。 特别地，本发明提供能够增强气味受体活化的多肽（例如，3型毒蕈碱乙酰胆碱受体M3）。 本发明进一步提供了用于检测对各种气味受体特异性的配体的测定。 另外，本发明提供了筛选与气味受体激活相关的多肽多态性和突变（例如，与毒蕈碱性乙酰胆碱受体多肽（例如M1，M2，M3，M4，M5）相关的多态性和突变）的方法，以及方法 筛选治疗剂，配体和这些蛋白质的调节剂。
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公开(公告)号：WO2008008224A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/015288
申请日：2007-07-10
Applicant: DUKE UNIVERSITY , MATSUNAMI, Hiroaki , MATSUNAMI, Momoka , ISHIMARU, Yoshiro
Inventor： MATSUNAMI, Hiroaki , MATSUNAMI, Momoka , ISHIMARU, Yoshiro
IPC: G01N33/53
CPC classification number: G01N33/566
Abstract: The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste receptor protein mutations that are associated with disease states, and therapeutic agents, ligands, and modulators of such proteins. The present invention also provides compositions and methods for modulating sour taste receptors in vitro and in vivo.
Abstract translation: 本发明涉及酸味受体及其组合物和方法。 特别地，本发明提供筛选对酸味受体特异的配体的测定和方法。 此外，本发明提供了用于筛选与疾病状态相关的辅助蛋白质和突变，多态性和其他潜在酸味受体蛋白质突变的方法，以及这些蛋白质的治疗剂，配体和调节剂。 本发明还提供了用于体外和体内调节酸味受体的组合物和方法。
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公开(公告)号：WO2006002161A2
公开(公告)日：2006-01-05
申请号：PCT/US2005021921
申请日：2005-06-20
Applicant: UNIV DUKE , MATSUNAMI HIROAKI , MATSUNAMI MOMOKA , SAITO HARUMI , ZHUANG HANYI
Inventor： MATSUNAMI HIROAKI , MATSUNAMI MOMOKA , SAITO HARUMI , ZHUANG HANYI
IPC: C12Q1/68
CPC classification number: C07K14/47 , C07K14/4705 , C12N2503/02 , C12N2510/00 , G01N33/5041 , G01N33/5058 , G01N33/6893 , G01N33/74 , G01N2333/726 , G01N2500/00 , G01N2500/04
Abstract: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.
Abstract translation: 本发明涉及能够促进加味剂受体细胞表面定位和气味受体功能表达的多肽。 本发明还提供了检测各种加臭剂受体特异性配体的测定。 此外，本发明提供了筛选加味剂受体辅助蛋白多态性和与疾病状态相关的突变的方法，以及筛选此类蛋白质的治疗剂，配体和调节剂的方法。
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公开(公告)号：WO2011069156A3
公开(公告)日：2011-08-11
申请号：PCT/US2010059093
申请日：2010-12-06
Applicant: UNIV DUKE , MATSUNAMI HIROAKI , LI YUN
Inventor： MATSUNAMI HIROAKI , LI YUN
CPC classification number: C12Q1/6881 , C07K14/70571 , C12Q2600/136 , C12Q2600/156
Abstract: The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine receptor M3) capable of enhancing odorant receptor activation. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for polypeptide polymorphisms and mutations associated with odorant receptor activation (e.g., polymorphisms and mutations associated with muscarinic actetylcholine receptor polypeptides (e.g., M1, M2, M3, M4, M5)), as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.
Abstract translation: 本发明涉及能够调节气味受体活化的多肽。 特别地，本发明提供能够增强加味剂受体活化的多肽（例如，3型毒蕈碱性乙酰胆碱受体M3）。 本发明还提供了检测各种加臭剂受体特异性配体的测定法。 此外，本发明提供了筛选多肽多态性和与气味受体激活相关的突变的方法（例如，与毒蕈碱性乙酰胆碱受体多肽（例如，M1，M2，M3，M4，M5）相关的多态性和突变）以及方法 筛选这些蛋白质的治疗剂，配体和调节剂。
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7.发明申请COMPOSITIONS AND METHODS FOR CHARACTERIZING AND REGULATING OLFACTORY SENSATION 审中-公开用于表征和调节OLFACTORY SENSATION的组合物和方法
公开(公告)号：WO2008137993A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/063073
申请日：2008-05-08
Applicant: DUKE UNIVERSITY , THE ROCKEFELLER UNIVERSITY , MATSUNAMI, Hiroaki , KELLER, Andreas , ZHUANG, Hanyi , CHI, Qiuyi , VOSSHALL, Leslie, B.
Inventor： MATSUNAMI, Hiroaki , KELLER, Andreas , ZHUANG, Hanyi , CHI, Qiuyi , VOSSHALL, Leslie, B.
CPC classification number: C12Q1/6897 , C12Q1/6876 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/566 , G01N2333/726 , G01N2500/04
Abstract: The present invention relates to the characterization of odorant receptors. In particular, the present invention relates to the OR7D4 proteins and nucleic acids encoding OR7D4 proteins and cell systems for screening for modulators of OR7D4 receptors. The present invention further provides assays for the detection of OR7D4 polymorphisms and mutations associated with altered olfactory sensation states, as well as methods of screening for therapeutic agents, ligands, and modulators of OR7D4 receptors.
Abstract translation: 本发明涉及加臭剂受体的表征。 特别地，本发明涉及编码OR7D4蛋白质的OR7D4蛋白质和核酸以及用于筛选OR7D4受体调节剂的细胞系统。 本发明还提供了用于检测OR7D4多态性和与改变的嗅觉状态相关的突变的检测方法，以及筛选OR7D4受体的治疗剂，配体和调节剂的方法。
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