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    SYSTEMS AND METHODS FOR TISSUE CHARACTERIZATION USING MULTIPLE APERTURE ULTRASOUND
    1.
    发明申请
    SYSTEMS AND METHODS FOR TISSUE CHARACTERIZATION USING MULTIPLE APERTURE ULTRASOUND 审中-公开

    公开(公告)号：WO2022086521A1

    公开(公告)日：2022-04-28

    申请号：PCT/US2020/056652

    申请日：2020-10-21

    Applicant: MAUI IMAGING, INC.

    Inventor： SPECHT, David, J. ,  SMITH, David, M. ,  ATMEH, Elias, M. ,  CALL, Josef, R.

    IPC: A61B8/14 ,  G06K9/46 ,  G01S15/88 ,  G06T7/10

    Abstract: Changes in tissue stiffness have long been associated with disease. Systems and methods for determining the stiffness of tissues using ultrasonography may include a device for inducing a propagating shear wave in tissue and tracking the speed of propagation, which is directly related to tissue stiffness and density. The speed of a propagating shear wave may be detected by imaging a tissue at a high frame rate and detecting the propagating wave as a perturbance in successive image frames relative to a baseline image of the tissue in an undisturbed state. In some embodiments, sufficiently high frame rates may be achieved by using a ping-based ultrasound imaging technique in which unfocused omni-directional pings are transmitted (in an imaging plane or in a hemisphere) into a region of interest. Receiving echoes of the omnidirectional pings with multiple receive apertures allows for substantially improved lateral resolution.

    CALIBRATION OF MULTIPLE APERTURE ULTRASOUND PROBES
    5.
    发明申请
    CALIBRATION OF MULTIPLE APERTURE ULTRASOUND PROBES 审中-公开
    多孔超声探头校准

    公开(公告)号：WO2014026185A1

    公开(公告)日：2014-02-13

    申请号：PCT/US2013/054515

    申请日：2013-08-12

    Applicant: MAUI IMAGING, INC.

    Inventor： CALL, Josef, R. ,  OSBORN, Nathan, W. ,  BELEVICH, Artem ,  RITZI, Bruce, R.

    IPC: G01S15/89 ,  G01S15/02 ,  A61B8/00

    CPC classification number: A61B8/587 ,  A61B6/584 ,  A61B8/12 ,  A61B8/4477 ,  A61B8/4488 ,  A61B8/4494 ,  A61B8/483 ,  G01S7/52052

    Abstract: The quality of ping-based ultrasound imaging is dependent on the accuracy of information describing the precise acoustic position of transmitting and receiving transducer elements. Improving the quality of transducer element position data can substantially improve the quality of ping-based ultrasound images, particularly those obtained using a multiple aperture ultrasound imaging probe, i.e., a probe with a total aperture greater than any anticipated maximum coherent aperture width. Various systems and methods for calibrating element position data for a probe are described.

    Abstract translation: 基于ping的超声成像的质量取决于描述发送和接收传感器元件的精确声位置的信息的准确性。 提高换能器元件位置数据的质量可以显着地提高基于乒乓的超声图像的质量，特别是使用多孔超声成像探针，即具有大于任何预期的最大相干孔径宽度的总孔径的探针获得的超声图像的质量。 描述用于校准探针的元件位置数据的各种系统和方法。

    SYSTEMS AND METHODS FOR IMPROVING ULTRASOUND IMAGE QUALITY BY APPLYING WEIGHTING FACTORS
    6.
    发明申请
    SYSTEMS AND METHODS FOR IMPROVING ULTRASOUND IMAGE QUALITY BY APPLYING WEIGHTING FACTORS 审中-公开
    通过应用加权因子改善超声图像质量的系统和方法

    公开(公告)号：WO2013148673A1

    公开(公告)日：2013-10-03

    申请号：PCT/US2013/033867

    申请日：2013-03-26

    Applicant: MAUI IMAGING, INC.

    Inventor： CALL, Josef, R. ,  SPECHT, Donald, F. ,  BREWER, Kenneth, D.

    IPC: A61B8/00 ,  G01N29/24 ,  G06T5/00

    CPC classification number: A61B8/145 ,  A61B8/4245 ,  A61B8/4427 ,  A61B8/4477 ,  A61B8/4488 ,  A61B8/5207 ,  A61B8/5253 ,  A61B8/54 ,  G01S7/52046 ,  G01S7/52063 ,  G01S15/8913 ,  G01S15/8927 ,  G01S15/8952

    Abstract: Systems and methods for improving the quality of ultrasound images made up of a combination of multiple sub-images include giving more weight to sub-image information that is more likely to improve a combined image quality. Weighting factor information may be determined from the geometry (e.g., angle or path length) of a location of one or more specific transducer elements relative to a specific point within a region of interest or a region of an image. In some embodiments, any given pixel (or other discrete region of an image) may be formed by combining received echo data in a manner that gives more weight to data that is likely to improve image quality, and/or discounting or ignoring data that is likely to detract from image quality (e.g., by introducing noise or by increasing point spread).

    Abstract translation: 用于改善由多个子图像的组合构成的超声图像的质量的系统和方法包括对更可能提高组合图像质量的子图像信息给予更多的权重。 加权因子信息可以根据感兴趣区域或图像区域中的一个或多个特定换能器元件的位置的几何（例如，角度或路径长度）来确定。 在一些实施例中，任何给定像素（或图像的其它离散区域）可以通过以接收到的回波数据的方式形成，该方式对于可能提高图像质量的数据给予更多的权重，和/或打折或忽略 可能会降低图像质量（例如，通过引入噪声或增加点扩散）。

    POINT SOURCE TRANSMISSION AND SPEED-OF-SOUND CORRECTION USING MULT-APERTURE ULTRASOUND IMAGING
    7.
    发明申请
    POINT SOURCE TRANSMISSION AND SPEED-OF-SOUND CORRECTION USING MULT-APERTURE ULTRASOUND IMAGING 审中-公开
    采用多孔超声成像进行点源传输和声速校正

    公开(公告)号：WO2011103303A3

    公开(公告)日：2011-11-17

    申请号：PCT/US2011025263

    申请日：2011-02-17

    Applicant: MAUI IMAGING INC ,  SPECHT DONALD F ,  BREWER KENNETH D

    Inventor： SPECHT DONALD F ,  BREWER KENNETH D

    IPC: A61B8/14

    CPC classification number: A61B8/5246 ,  A61B8/14 ,  A61B8/145 ,  A61B8/4444 ,  A61B8/4455 ,  A61B8/4477 ,  A61B8/4483 ,  A61B8/463 ,  A61B8/5207 ,  A61B8/5269 ,  G01S7/52049 ,  G01S15/8913 ,  G01S15/8927 ,  G01S15/8961 ,  G01S15/8977 ,  G01S15/8993 ,  G01S15/8997

    Abstract: A Multiple Aperture Ultrasound Imaging system and methods of use are provided with any number of features. In some embodiments, a multi-aperture ultrasound imaging system is configured to transmit and receive ultrasound energy to and from separate physical ultrasound apertures. In some embodiments, a transmit aperture of a multi-aperture ultrasound imaging system is configured to transmit an omni-directional unfocused ultrasound waveform approximating a first point source through a target region. In some embodiments, the ultrasound energy is received with a single receiving aperture. In other embodiments, the ultrasound energy is received with multiple receiving apertures. Algorithms are described that can combine echoes received by one or more receiving apertures to form high resolution ultrasound images. Additional algorithms can solve for variations in tissue speed of sound, thus allowing the ultrasound system to be used virtually anywhere in or on the body.

    Abstract translation: 提供了多孔特征的多孔超声成像系统和使用方法。 在一些实施例中，多孔径超声成像系统被配置成将超声能量发射到单独的物理超声孔径并从其接收。 在一些实施例中，多孔超声成像系统的发射孔径被配置成通过目标区域发射近似于第一点源的全向未聚焦超声波形。 在一些实施例中，利用单个接收孔接收超声能量。 在其他实施例中，超声能量被多个接收孔接收。 描述了可以组合由一个或多个接收孔接收的回波以形成高分辨率超声图像的算法。 附加的算法可以解决组织声速变化，从而使超声系统几乎可以用在身体内或身体上的任何地方。

    MULTIPLE APERTURE ULTRASOUND ARRAY ALIGNMENT FIXTURE
    9.
    发明申请
    MULTIPLE APERTURE ULTRASOUND ARRAY ALIGNMENT FIXTURE 审中-公开
    多孔超声波阵列对准装置

    公开(公告)号：WO2010120907A2

    公开(公告)日：2010-10-21

    申请号：PCT/US2010031067

    申请日：2010-04-14

    Applicant: MAUI IMAGING INC ,  SPECHT DONALD F ,  BREWER KENNETH D ,  SMITH DAVID M ,  ADAM SHARON L ,  LUNSFORD JOHN P

    Inventor： SPECHT DONALD F ,  BREWER KENNETH D ,  SMITH DAVID M ,  ADAM SHARON L ,  LUNSFORD JOHN P

    IPC: A61B8/08 ,  G01N29/24

    CPC classification number: A61B8/42 ,  A61B8/00 ,  A61B8/0883 ,  A61B8/4218 ,  A61B8/4444 ,  A61B8/4477 ,  A61B8/587 ,  G01S7/5205 ,  G01S15/8913 ,  Y10T29/49778

    Abstract: Increasing the effective aperture of an ultrasound imaging probe by including more than one probe head and using the elements of all of the probes to render an image can greatly improve the lateral resolution of the generated image. In order to render an image, the relative positions of all of the elements must be known precisely. A calibration fixture is described in which the probe assembly to be calibrated is placed above a test block and transmits ultrasonic pulses through the test block to an ultrasonic sensor. As the ultrasonic pulses are transmitted though some or all of the elements in the probe to be tested, the differential transit times of arrival of the waveform are measured precisely. From these measurements the relative positions of the probe elements can be computed and the probe can be aligned.

    Abstract translation: 通过包括多于一个探针头并使用所有探针的元件来渲染图像来增加超声成像探针的有效孔径可以极大地改善所产生的图像的横向分辨率。 为了呈现图像，必须精确地知道所有元素的相对位置。 描述了一种校准夹具，其中要校准的探针组件放置在测试块上方，并将超声波脉冲通过测试块传送到超声波传感器。 由于超声波脉冲通过要测试的探头中的一些或全部元件传输，波形的到达差分传递时间被精确地测量。 通过这些测量，可以计算探针元件的相对位置，并且可以对准探针。

    IMAGING WITH MULTIPLE APERTURE MEDICAL ULTRASOUND AND SYNCHRONIZATION OF ADD-ON SYSTEMS
    10.
    发明申请
    IMAGING WITH MULTIPLE APERTURE MEDICAL ULTRASOUND AND SYNCHRONIZATION OF ADD-ON SYSTEMS 审中-公开
    多光谱医学超声成像与附加系统的同步化

    公开(公告)号：WO2010017445A2

    公开(公告)日：2010-02-11

    申请号：PCT/US2009/053096

    申请日：2009-08-07

    Applicant: MAUI IMAGING, INC. ,  SPECHT, Donald, F. ,  BREWER, Kenneth, D.

    Inventor： SPECHT, Donald, F. ,  BREWER, Kenneth, D.

    IPC: A61B8/00 ,  G01N29/24 ,  G01N29/36

    CPC classification number: A61B8/5207 ,  A61B8/4281 ,  A61B8/4477 ,  A61B8/54 ,  G01S7/52046 ,  G01S7/52087 ,  G01S15/8913 ,  G01S15/8927 ,  G01S15/8929 ,  G01S15/8997

    Abstract: The benefits of a multi-aperture ultrasound probe can be achieved with add-on devices. Synchronization and correlation of echoes from multiple transducer elements located in different arrays is essential to the successful processing of multiple aperture imaging. The algorithms disclosed here teach methods to successfully process these signals when the transmission source is coming from another ultrasound system and synchronize the add-on system to the other ultrasound system. Two-dimensional images with different noise components can be constructed from the echoes received by individual transducer elements. The disclosed techniques have broad application in medical imaging and are ideally suited to multi-aperture cardiac imaging using two or more intercostal spaces.

    Abstract translation:

    多孔超声探头的优点可以通过附加设备实现。 来自位于不同阵列中的多个换能器元件的回波的同步和相关对于多孔径成像的成功处理是必不可少的。 这里公开的算法教导了当传输源来自另一超声系统并使附加系统与另一超声系统同步时成功处理这些信号的方法。 具有不同噪声分量的二维图像可以由各个换能器元件接收的回波构建。 所公开的技术在医学成像中具有广泛的应用，并且理想地适用于使用两个或更多个肋间隙的多孔心脏成像。

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