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    MICRO-NEEDLE ARRAY
    2.
    发明申请
    MICRO-NEEDLE ARRAY 审中-公开
    微针阵列

    公开(公告)号：WO2011017023A1

    公开(公告)日：2011-02-10

    申请号：PCT/US2010/043011

    申请日：2010-07-23

    Applicant: COOK INCORPORATED ,  MELSHEIMER, Jeffry, S.

    Inventor： MELSHEIMER, Jeffry, S.

    IPC: A61M37/00 ,  A61B17/20 ,  A61K9/00

    CPC classification number: A61K9/0021 ,  A61M37/0015 ,  A61M2025/1086 ,  A61M2037/003 ,  A61M2037/0038 ,  A61M2037/0053 ,  B33Y80/00

    Abstract: A micro-needle array (1) is provided that may be used to deliver a bioactive agent to a therapeutic target. The micro-needle array preferably includes a substrate, a plurality of micro-needles integral with the substrate, and a bioactive agent. At least one micro-needle preferably includes a top surface (12), a bottom surface (14), a side surface (17), and a cavity (18) defined by an inner surface. The bioactive agent may be disposed on the substrate and the plurality of micro-needles. The at least one micro-needle may further include a slit (26) connecting the cavity to an aperture, the slit extending from the top surface to the bottom surface.

    Abstract translation: 提供了可用于将生物活性剂递送至治疗靶的微针阵列（1）。 微针阵列优选地包括基底，与基底一体的多个微针和生物活性剂。 至少一个微针优选地包括顶表面（12），底表面（14），侧表面（17）和由内表面限定的空腔（18）。 生物活性剂可以设置在基材和多个微针上。 至少一个微针还可以包括将空腔连接到孔的狭缝（26），所述狭缝从顶表面延伸到底表面。

    LOADING DILATOR WITH A VARIABLE GIRTH IN A LOCALIZED AREA
    4.
    发明申请
    LOADING DILATOR WITH A VARIABLE GIRTH IN A LOCALIZED AREA 审中-公开
    在一个本地化区域装载可变化的女孩

    公开(公告)号：WO2008091776A1

    公开(公告)日：2008-07-31

    申请号：PCT/US2008/051264

    申请日：2008-01-17

    Applicant: COOK CRITICAL CARE INCORPORATED ,  MELSHEIMER, Jeffry, S.

    Inventor： MELSHEIMER, Jeffry, S.

    IPC: A61M16/04 ,  A61B17/34

    CPC classification number: A61M16/0472 ,  A61B17/3415 ,  A61B2017/3486 ,  A61M16/0434 ,  A61M16/0488 ,  A61M2025/0687 ,  A61M2210/1032

    Abstract: A loading dilator (10) introducing a tracheostomy tube (100) into a stoma (140) formed in an outer body wall of a patient includes a handle (12) and a tubular portion (14) received in a distal opening (61) of the handle. The tubular portion includes a radially outer dilator member (20), and a radially inner actuation member (32) substantially spanning the length of the tubular portion. A radially intermediate segment has a conical member (26) at a tapered distal end of the tubular portion, a compressible member (30) positioned proximal of the conical member, and an elongated tubular member (40) proximal of the compressible member. The conical member is engaged with the inner actuation member such that the conical member and inner actuation member are proximally movable relative to the elongated tubular member, whereby the compressible member is deformable from a smaller diameter to a larger diameter for facilitating entry into the stoma of a medical apparatus. The handle has a trigger (80) operatively engaged with the inner actuation member for effecting proximal movement of the inner actuation member and conical portion.

    Abstract translation: 将气管造口管（100）引入形成在患者的外部体壁中的造口（140）的加载扩张器（10）包括手柄（12）和容纳在远端开口（61）中的管状部分（14） 手柄。 管状部分包括径向外部扩张器构件（20）和径向内部致动构件（32），其基本跨越管状部分的长度。 径向中间段在管状部分的锥形远端处具有锥形构件（26），位于锥形构件的近侧的可压缩构件（30）和可压缩构件的近侧的细长管状构件（40）。 圆锥形构件与内部致动构件接合，使得圆锥形构件和内部致动构件相对于细长管状构件可向近侧移动，由此可压缩构件可从较小直径变形为较大直径，以便于进入造口 医疗器械 手柄具有与内部致动构件可操作地接合的触发器（80），用于实现内部致动构件和锥形部分的近侧运动。

    WIRE GUIDE HAVING DISTAL COUPLING TIP
    5.
    发明申请
    WIRE GUIDE HAVING DISTAL COUPLING TIP 审中-公开
    具有远程联轴器提示的导线

    公开(公告)号：WO2007089893A1

    公开(公告)日：2007-08-09

    申请号：PCT/US2007/002743

    申请日：2007-01-31

    Applicant: COOK INCORPORATED ,  MELSHEIMER, Jeffry, S.

    Inventor： MELSHEIMER, Jeffry, S.

    IPC: A61M25/09

    CPC classification number: A61M25/09 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/007 ,  A61M2025/018 ,  A61M2025/09083 ,  A61M2025/09175

    Abstract: A coupling wire guide is structured to be slidably coupled to a previously introduced wire guide, and is also well suited for stand-alone use. The coupling wire guide generally includes a main body having a distal end and a coupling tip connection to the distal end. The coupling tip includes a coupling portion and a tip portion. The coupling portion defines a coupling passageway having a proximal port and distal port for receiving a previously introduced wire guide. The tip portion includes a distal end surface having an atraumatic shape.

    Abstract translation: 联接导线器构造成可滑动地联接到先前引入的导线器，并且也非常适合于独立使用。 联接线导向器通常包括主体，该主体具有远端和与远端的联接尖端连接。 联接尖端包括联接部分和尖端部分。 联接部分限定了具有近端端口和远端端口的联接通道，用于接收先前引入的导线器。 尖端部分包括具有无创伤形状的远端表面。

    CATHETER ASSEMBLY WITH PLAQUE CUTTING BALLOON
    6.
    发明申请
    CATHETER ASSEMBLY WITH PLAQUE CUTTING BALLOON 审中-公开
    导流板总成与切割气球

    公开(公告)号：WO2006073933A3

    公开(公告)日：2006-09-08

    申请号：PCT/US2005047054

    申请日：2005-12-28

    Applicant: COOK INC ,  MELSHEIMER JEFFRY S ,  BURTON DAVID G

    Inventor： MELSHEIMER JEFFRY S ,  BURTON DAVID G

    IPC: A61M25/00 ,  A61B17/22

    CPC classification number: A61B17/320725 ,  A61B2017/22051 ,  A61B2017/22061 ,  A61M25/1027 ,  A61M25/1038 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/1086 ,  A61M2025/109

    Abstract: A balloon catheter assembly comprises an elongate catheter shaft having a proximal portion and a distal portion, and an inflatable balloon secured to the shaft distal portion. A plurality of cutters are arranged along an outer surface of the balloon. The cutters are shielded by folds of the balloon when the balloon is uninflated, and are arranged and configured to facilitate breakdown of a vascular restriction when said balloon is inflated. Preferably, the cutters are arranged in at least three generally parallel longitudinal rows along the balloon outer surface, and there are at least three longitudinally-aligned cutters in each row. Preferably, the cutters are formed of the same or a similar base composition as the balloon, and are bonded to the balloon outer surface.

    Abstract translation: 气囊导管组件包括具有近端部分和远端部分的细长导管轴以及固定到轴远端部分的可膨胀气囊。 多个切割器沿球囊的外表面排列。 当球囊未充气时，切割器被球囊的褶皱屏蔽，并且被布置和构造成在所述球囊膨胀时促进血管限制的破坏。 优选地，切割器沿着气囊外表面布置成至少三个大致平行的纵向排，并且在每排中存在至少三个纵向对齐的切割器。 优选地，切割器由与球囊相同或相似的基础成分形成，并且结合到球囊外表面。

    DELIVERY OF AN EMBOLIZATION COIL WITH AN ATTACHER
    7.
    发明申请
    DELIVERY OF AN EMBOLIZATION COIL WITH AN ATTACHER 审中-公开

    公开(公告)号：WO2012092351A3

    公开(公告)日：2012-07-05

    申请号：PCT/US2011/067551

    申请日：2011-12-28

    Applicant: COOK MEDICAL TECHNOLOGIES LLC ,  KURRUS, Michael, R. ,  MOORE, William, F. ,  MELSHEIMER, Jeffry, S. ,  EVERT, Kathryn, R.

    Inventor： KURRUS, Michael, R. ,  MOORE, William, F. ,  MELSHEIMER, Jeffry, S. ,  EVERT, Kathryn, R.

    IPC: A61B17/12

    Abstract: An occluding device apparatus includes an embolization coil with a distal end and a proximal end with an opening and an attacher that is threaded through the opening at the proximal end of the embolization coil. The apparatus further comprises a delivery kit for delivery of the embolization coil in a body cavity. The kit comprises a guide catheter for percutaneous introduction of the embolization coil and an inner catheter slidably disposed within the guide catheter during insertion. The inner catheter comprises a proximal end and a distal end. The inner catheter further includes a hub disposed adjacent the proximal end. The kit further comprises a guide wire slidably disposed within the inner catheter. The guide wire is configured to provide a path during insertion thereof within a body cavity. The kit further comprises a pushwire to advance the embolization coil through the inner catheter.

    DELIVERY OF AN EMBOLIZATION COIL WITH AN ATTACHER
    8.
    发明申请
    DELIVERY OF AN EMBOLIZATION COIL WITH AN ATTACHER 审中-公开
    用附着器递送栓塞线圈

    公开(公告)号：WO2012092351A2

    公开(公告)日：2012-07-05

    申请号：PCT/US2011067551

    申请日：2011-12-28

    Applicant: COOK MEDICAL TECHNOLOGIES LLC ,  KURRUS MICHAEL R ,  MOORE WILLIAM F ,  MELSHEIMER JEFFRY S ,  EVERT KATHRYN R

    Inventor： KURRUS MICHAEL R ,  MOORE WILLIAM F ,  MELSHEIMER JEFFRY S ,  EVERT KATHRYN R

    IPC: A61B17/12

    CPC classification number: A61B17/12022 ,  A61B2017/00477 ,  A61B2017/00871 ,  A61B2017/12054 ,  A61B2017/12095

    Abstract: An occluding device apparatus includes an embolization coil with a distal end and a proximal end with an opening and an attacher that is threaded through the opening at the proximal end of the embolization coil. The apparatus further comprises a delivery kit for delivery of the embolization coil in a body cavity. The kit comprises a guide catheter for percutaneous introduction of the embolization coil and an inner catheter slidably disposed within the guide catheter during insertion. The inner catheter comprises a proximal end and a distal end. The inner catheter further includes a hub disposed adjacent the proximal end. The kit further comprises a guide wire slidably disposed within the inner catheter. The guide wire is configured to provide a path during insertion thereof within a body cavity. The kit further comprises a pushwire to advance the embolization coil through the inner catheter.

    Abstract translation: 闭塞装置装置包括具有远端和具有开口的近端的栓塞线圈以及穿过栓塞线圈的近端处的开口的连接器。 该设备还包括用于将栓塞线圈输送到体腔中的输送套件。 该套件包括用于经皮引入栓塞线圈的引导导管和在插入期间可滑动地设置在引导导管内的内导管。 内导管包括近端和远端。 内导管还包括邻近近端设置的毂。 该套件还包括可滑动地设置在内导管内的导丝。 导丝被构造成在其插入体腔期间提供路径。 该套件还包括推线以推进栓塞线圈通过内导管。

    LOADING APPARATUS AND SYSTEM FOR EXPANDABLE INTRALUMINAL MEDICAL DEVICES
    10.
    发明申请
    LOADING APPARATUS AND SYSTEM FOR EXPANDABLE INTRALUMINAL MEDICAL DEVICES 审中-公开
    用于可扩展的内镜医疗装置的装载装置和系统

    公开(公告)号：WO2011022658A1

    公开(公告)日：2011-02-24

    申请号：PCT/US2010/046181

    申请日：2010-08-20

    Applicant: COOK INCORPORATED ,  MELSHEIMER, Jeffry, S. ,  BURKE, Jessica, L. ,  CHAMBERS, Sean, D. ,  VALAIE, Arman

    Inventor： MELSHEIMER, Jeffry, S. ,  BURKE, Jessica, L. ,  CHAMBERS, Sean, D. ,  VALAIE, Arman

    IPC: A61F2/84

    CPC classification number: A61F2/95 ,  A61F2/2436 ,  A61F2/844 ,  A61F2/92 ,  A61F2002/9511 ,  A61F2002/9522 ,  Y10T29/53843

    Abstract: Medical device loading apparatuses, systems, methods and kits are described. A loading apparatus comprises a main body having a proximal end defining a proximal opening, a distal end defining a distal opening, and a passageway extending between the proximal and distal openings. The passageway defines a proximal chamber having a first inner diameter, a distal chamber having a second inner diameter, and a transition chamber disposed between the proximal and distal chambers. The transition chamber has an inner diameter that transitions from the larger second inner diameter to the smaller first inner diameter. The main body has a separable connection that divides the main body between proximal and distal portions when disrupted. An expandable intraluminal medical device can be loaded into a delivery catheter using the loading apparatus by placing the device into the passageway such that it is in a radially-expanded configuration; pulling the device along an axial path through the loading apparatus such that the device transitions from the radially-expanded configuration to a radially-compressed configuration; and pushing the radially-compressed device along the axial path into the delivery catheter.

    Abstract translation: 描述了医疗装置装载装置，系统，方法和试剂盒。 装载装置包括主体，其具有限定近端开口的近端，限定远侧开口的远端以及在近端开口和远端开口之间延伸的通道。 所述通道限定具有第一内径的近侧腔室，具有第二内径的远侧腔室，以及设置在近端腔室和远端腔室之间的过渡腔室。 过渡室具有从较大的第二内径向较小的第一内径转变的内径。 主体具有可分离的连接，当中断时将主体分成近端部分和远端部分之间。 可扩张的管腔内医疗装置可以通过将装置放入通道使其处于径向扩张的构型中而使用装载装置装载到输送导管中; 沿着轴向路径拉动装置通过装载装置，使得装置从径向扩张构型转变成径向压缩构型; 并将径向压缩的装置沿轴向路径推入输送导管。

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