中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

152 records (took 0.035 seconds)

    SKIN INNATE RESPONSE LINKED TO PROTECTIVE INTRADERMAL VACCINATION AGAINST RESPIRATORY INFECTION
    1.
    发明申请
    SKIN INNATE RESPONSE LINKED TO PROTECTIVE INTRADERMAL VACCINATION AGAINST RESPIRATORY INFECTION 审中-公开
    皮肤刺激反应与抗呼吸道感染相关的保护性入侵疫苗

    公开(公告)号：WO2015085242A1

    公开(公告)日：2015-06-11

    申请号：PCT/US2014/068913

    申请日：2014-12-05

    Applicant: MERIAL LIMITED

    Inventor： ANDREONI, Christine

    IPC: A61K39/245 ,  A61K39/00

    CPC classification number: A61K39/12 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/572 ,  A61K2039/575 ,  C12N2710/16734

    Abstract: Intradermal (ID) vaccination aims at targeting the large network of skin antigen-presenting dendritic cells (DC) and constitutes a promising approach to improve anti-infectious immunity. Yet, its anti-viral protective efficacy for sub-unit vaccines and the underlying skin innate immune mechanisms remains to be explored for a wider usage in humans. Using a pig model of lethal respiratory infection with pseudorabies virus (PRV), we show that ID vaccination with adjuvant-free PRV glycoproteins triggers cellular and humoral immunity and confers protection from disease induction by nasal viral challenge, as efficiently as an oil- adjuvanted reference vaccine delivered intramuscularly.

    Abstract translation: 皮内（ID）疫苗接种旨在针对皮肤抗原呈递树突状细胞（DC）的大网络，并构成了改善抗感染免疫力的有希望的方法。 然而，其对亚单位疫苗的抗病毒保护功效和潜在的皮肤先天免疫机制仍有待探索，以便在人类中得到更广泛的应用。 使用具有伪狂犬病病毒（PRV）的致死性呼吸道感染的猪模型，我们显示使用无佐剂的PRV糖蛋白进行ID疫苗接种可触发细胞和体液免疫，并通过鼻病毒攻击赋予保护免受疾病诱导，作为油佐剂化参考 肌内注射疫苗。

    METHOD OF PROVIDING PROTECTIVE IMMUNITY AGAINST HETEROLOGOUS LEPTOSPIRA STRAINS
    3.
    发明申请
    METHOD OF PROVIDING PROTECTIVE IMMUNITY AGAINST HETEROLOGOUS LEPTOSPIRA STRAINS 审中-公开
    提供保护性免疫对抗病毒性紫癜菌株的方法

    公开(公告)号：WO2014014725A1

    公开(公告)日：2014-01-23

    申请号：PCT/US2013/049997

    申请日：2013-07-11

    Applicant: MERIAL LIMITED

    Inventor： PARDO, Maria, Camila

    IPC: A61K39/02

    CPC classification number: A61K39/0225 ,  A61K39/00 ,  A61K2039/521 ,  A61K2039/552 ,  A61K2039/58 ,  A61K2039/70

    Abstract: The present invention provides compositions and methods for eliciting protective immunity in animals against Leptospira Interrogans (LI) serovar copenhageni. The invention is based, in part, on the unexpected cross-protection against heterologous LI serovar, which resulted when canines were administered an effective amount of RECOMBITEK® 4 Lepto, then subsequently challenged with virulent L. copenhageni (Fiocruz Ll-130).

    Abstract translation: 本发明提供在动物中引发针对钩端螺旋体钩端螺旋体（LI）血清型copenhageni的保护性免疫的组合物和方法。 本发明部分基于对异源LI血清型的意想不到的交叉保护，其在犬科动物施用有效量的RECOMBITEK®4 Lepto时产生，随后用有毒的L. copenhageni（Fiocruz L1-130）攻击。

    INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE
    9.
    发明申请
    INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE 审中-公开
    杀虫剂4-氨基 - 噻吩并[2,3-D] - 嘧啶化合物及其使用方法

    公开(公告)号：WO2011014660A1

    公开(公告)日：2011-02-03

    申请号：PCT/US2010/043717

    申请日：2010-07-29

    Applicant: MERIAL LIMITED ,  SOLL, Mark, David ,  MENG, Charles, Q.

    Inventor： SOLL, Mark, David ,  MENG, Charles, Q.

    IPC: C07D495/04 ,  A01N43/90 ,  A01P7/00

    CPC classification number: C07D495/04 ,  A01N43/90 ,  A01N47/02

    Abstract: Insecticidal 4-Amino--thieno[2,3-d]-pyrimidine compounds and methods of their use to control pests that damage plants and crops and parasites that harm animals. The present invention relates to new insecticidal 4-Amino--thieno[2,3-d]-pyrimidine compounds and new methods of their use. The new 4-Amino--thieno[2,3-d]-pyrimidine derivatives have formula (I), wherein X, R 1 , R 2 , R 3 and A are defined as in the description. The invention relates also to their enantiomer, diastereomer or agriculturally or veterinary acceptable salt thereof. The invention relates also to agricultural and veterinary compositions comprising such compounds. The invention relates further also to different insecticidal methods applying such compounds and compositions.

    Abstract translation: 杀虫剂4-氨基 - 噻吩并[2,3-d] - 嘧啶化合物及其用于控制​​害虫损害动物的植物和作物及寄生虫的方法。 本发明涉及新的杀虫剂4-氨基 - 噻吩并[2,3-d]嘧啶化合物及其应用的新方法。 新的4-氨基 - 噻吩并[2,3-d]嘧啶衍生物具有式（I），其中X，R 1，R 2，R 3和A如描述中所定义。 本发明还涉及它们的对映异构体，非对映异构体或农业上或兽医学上可接受的盐。 本发明还涉及包含这种化合物的农业和兽用组合物。 本发明还涉及应用这种化合物和组合物的不同杀虫方法。

    ANTIBIOTIC-FREE PLASMID
    10.
    发明申请
    ANTIBIOTIC-FREE PLASMID 审中-公开
    抗生素免费PLASMID

    公开(公告)号：WO2010135742A1

    公开(公告)日：2010-11-25

    申请号：PCT/US2010/035979

    申请日：2010-05-24

    Applicant: MERIAL LIMITED ,  AUDONNET, Jean-christophe ,  JOLIVET, Edmond

    Inventor： AUDONNET, Jean-christophe ,  JOLIVET, Edmond

    IPC: C12N15/73 ,  C12N15/63 ,  C12N15/68

    CPC classification number: C12N15/73 ,  C12N15/635 ,  C12N15/85 ,  C12N2800/107 ,  C12N2800/24 ,  C12P21/00

    Abstract: The present invention provides a method of maintaining a gram negative bacterium plasmid without the use of antibiotic selection pressure. Further, the invention relates to the drugless plasmids produced including drugless plasmids containing a heterologous gene. The invention also provides formulations and/or compositions comprising the drugless plasmids comprising a heterologous gene, formulations and/or compositions comprising a protein or an immunogen expressed using the drugless plasmids, and methods of administering such formulations and/or compositions to a host. The invention relates to gram negative bacteria containing the drugless plasmids.

    Abstract translation: 本发明提供了不使用抗生素选择压力来维持革兰氏阴性细菌质粒的方法。 此外，本发明涉及包含含有异源基因的无毒素质粒产生的无毒素质粒。 本发明还提供了包含含有异源基因，包含使用无药物质粒表达的蛋白质或免疫原的制剂和/或组合物的制剂和/或组合物的制剂和/或组合物，以及向宿主施用这些制剂和/或组合物的方法。 本发明涉及含有无毒素质粒的革兰氏阴性细菌。

Patent Agency Ranking