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    ANTIMICROBIAL AND CLEANSING COMPOSITION CONSISTING OF A POLYMERIC BIGUANIDE AND EDTA
    2.
    发明申请
    ANTIMICROBIAL AND CLEANSING COMPOSITION CONSISTING OF A POLYMERIC BIGUANIDE AND EDTA 审中-公开
    一种聚合双胍和EDTA组成的抗微生物和清洁组合物

    公开(公告)号：WO2017137419A1

    公开(公告)日：2017-08-17

    申请号：PCT/EP2017/052713

    申请日：2017-02-08

    申请人： SUNMEDIC AB

    发明人： KARLADANI, Abbas

    IPC分类号： A61K9/00 ,  A61K47/14 ,  A61K47/18 ,  A61K31/14 ,  A61K31/155 ,  A61K31/198 ,  A61P17/02

    CPC分类号： A61K31/155 ,  A61K9/0014 ,  A61K31/14 ,  A61K31/198 ,  A61K47/14 ,  A61K47/18 ,  A61K2300/00

    摘要： The invention relates to a antimicrobial and cleansing composition consisting of a. a polymeric biguanide, and b. a metal ion chelating agent, and g. a solvent, wherein the ratio of a:b is between 0.75:2.25 and 1.25:2.25, or about 1:2, and optionally one or more of the following ingredients; c. a quaternary ammonium salt, d. at least one surfactant, e. a humectant and f. a gelling agent. The invention further relates to said composition for use in a treatment, prevention or reduction of a disease, disorder or condition related to microbials, or treatment, prevention or reduction of infection, or inflammation, or infected wounds, or inflamed wounds, or treatment, prevention or reduction of biofilms, or removal of necrotic tissue. A liquid flow system may be used for administration of the composition.

    摘要翻译： 本发明涉及一种抗微生物和清洁组合物，其由以下组分组成：a。 一种聚合双胍，和b。 金属离子螯合剂，和g。 其中a:b的比率在0.75:2.25和1.25:2.25之间，或约为1:2的溶剂，和任选的一种或多种下列成分; C。 季铵盐，d。 至少一种表面活性剂， 保湿剂和f。 一种胶凝剂。 本发明进一步涉及用于治疗，预防或减少与微生物有关的疾病，病症或病症或治疗，预防或减少感染或炎症，感染伤口或发炎伤口或治疗， 预防或减少生物膜或去除坏死组织。 液体流动系统可用于施用组合物。

    HAEMOLYSIS STABILISING COMPOSITION
    3.
    发明申请
    HAEMOLYSIS STABILISING COMPOSITION 审中-公开
    HAEMOLYSIS STABILIZING组合物

    公开(公告)号：WO2016186521A1

    公开(公告)日：2016-11-24

    申请号：PCT/NZ2016/050077

    申请日：2016-05-13

    申请人： CANTERBURY SCIENTIFIC LIMITED

    发明人： OWEN, Maurice Cedric

    IPC分类号： A61K31/00 ,  A61K33/00 ,  A61K31/198 ,  A61K31/14 ,  A61B5/00

    CPC分类号： A61B5/00 ,  A61K31/00 ,  A61K31/14 ,  A61K31/198 ,  A61K33/00 ,  G01N33/721 ,  G01N33/80

    摘要： Described herein are haemolysis stabilising compositions and methods of use in the medical industry for the analysis of whole blood samples from patients. The compositions contain a combination of agents comprising at least one red blood cell membrane solubilisation agent, at least one chelating agent, at least one methaemoglobin binding agent, at least one pH buffering agent, at least one anticoagulant agent and at least one haemoglobin stabilising agent that contributes to improved stability of haemoglobin during transportation at ambient temperatures and improved ease of use in collecting and analysing the collected whole blood samples.

    摘要翻译： 本文描述了溶血稳定化组合物和用于医疗行业中用于分析来自患者的全血样品的方法。 所述组合物含有包含至少一种红细胞膜增溶剂，至少一种螯合剂，至少一种血红蛋白结合剂，至少一种pH缓冲剂，至少一种抗凝血剂和至少一种血红蛋白稳定剂 有助于在环境温度下运输期间改善血红蛋白的稳定性，并且改善了在收集和分析所收集的全血样品时的易用性。

    IONIC NANOVESICLE SUSPENSION AND BIOCIDE PREPARED THEREFROM
    7.
    发明申请
    IONIC NANOVESICLE SUSPENSION AND BIOCIDE PREPARED THEREFROM 审中-公开
    IONIC纳米晶体悬浮液和生物制剂

    公开(公告)号：WO2016126982A1

    公开(公告)日：2016-08-11

    申请号：PCT/US2016/016629

    申请日：2016-02-04

    申请人： SELNER, Marc

    发明人： SELNER, Marc

    IPC分类号： A61K9/10

    CPC分类号： A61K47/06 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/10 ,  A61K31/14 ,  A61K31/155 ,  A61K31/7036 ,  A61K38/12

    摘要： A stable suspension, containing water, petrolatum, and at least one ionic biocide compound, wherein the suspension contains no added emulsifier, and all ionic biocide compounds present are either all cationic or all anionic, an ointment containing the stable suspension, and a method for producing the stable suspension.

    摘要翻译： 一种稳定的悬浮液，其含有水，凡士林和至少一种离子型杀生物剂化合物，其中所述悬浮液不含添加的乳化剂，并且所有存在的离子杀生物剂都是阳离子或全部阴离子的，含有稳定悬浮液的软膏，以及用于 产生稳定的悬浮液。

    QUATERNARY AMMONIUM COMPOUND FOR USE AS AN INHIBITOR OF PROTEIN KINASE C ALPHA
    10.
    发明申请
    QUATERNARY AMMONIUM COMPOUND FOR USE AS AN INHIBITOR OF PROTEIN KINASE C ALPHA 审中-公开
    季铵化合物用作蛋白激酶C抑制剂

    公开(公告)号：WO2016062884A1

    公开(公告)日：2016-04-28

    申请号：PCT/EP2015/074667

    申请日：2015-10-23

    申请人： SANTEN SAS

    发明人： DAULL, Philippe

    IPC分类号： A61K31/14 ,  A61P29/00 ,  A61P27/00 ,  A61P27/02

    CPC分类号： A61K31/14

    摘要： This invention relates to quaternary ammonium compound for use as an inhibitor of protein kinase C alpha, of formula (I) wherein: R 1 is selected from the group of alkyl, alkene, aryl or alkylaryl group; preferably R 1 is a benzyl, alkylbenzyl or alkylphenyl group; more preferably benzyl or methylphenyl group; optionally substituted by hydroxyl, oxo, nitro, amido, carboxy, amino, cyano, alkoxy, alkyl, alkene, alkyne, ester or heteroalkyl group; R 2 is an alkyl chain comprising at least 12 carbon atoms; preferably comprising 14, 16 or 18 carbon atoms; R 3 or R 4 are identical or different and each is selected from an alkyl chain; preferably a C1-C4 alkyl chain; more preferably is methyl group; X - is selected from an anion of a pharmaceutically acceptable acid or from halo group; preferably X - is selected from halo group; more preferably is Cl - or Br - . In particular, the present invention relates to the use of a long-chain quaternary ammonium of formula (I) as a wound healing and/or an anti-inflammatory agent for use in the treatment of eye conditions.

    摘要翻译： 本发明涉及用作蛋白激酶Cα抑制剂的式（I）的季铵化合物，其中：R1选自烷基，烯烃，芳基或烷基芳基; 优选R1是苄基，烷基苄基或烷基苯基; 更优选苄基或甲基苯基; 羟基，氧代，硝基，酰氨基，羧基，氨基，氰基，烷氧基，烷基，烯烃，炔，酯或杂烷基取代; R2是包含至少12个碳原子的烷基链; 优选包含14,16或18个碳原子; R3或R4相同或不同，各自选自烷基链; 优选C 1 -C 4烷基链; 更优选甲基; X-选自药学上可接受的酸或卤素的阴离子; 优选X选自卤素基团; 更优选为Cl-或Br-。 特别地，本发明涉及式（I）的长链季铵作为伤口愈合和/或抗炎药用于治疗眼睛病症的用途。