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1.发明申请ORTHO PYRROLIDINE, BENZYL-SUBSTITUTED HETEROCYCLE CCR1 ANTAGONISTS FOR AUTOIMMUNE DISEASES & INFLAMMATION 审中-公开ORTHO吡咯烷，苄基取代的杂交CCR1自身免疫性疾病和炎症的拮抗剂
公开(公告)号：WO2009082526A2
公开(公告)日：2009-07-02
申请号：PCT/US2008078743
申请日：2008-10-03
申请人： PHARMACOPEIA INC , PARADKAR VIDYADHAR M , BRESCIA MARC , JAMES RAY , LIU JINQI , MERRITT JAMES ROBERT , MORRIS MICHELLE , OHLMEYER MICHAEL J , ZHANG CHONGWU , ZHANG RUI
发明人： PARADKAR VIDYADHAR M , BRESCIA MARC , JAMES RAY , LIU JINQI , MERRITT JAMES ROBERT , MORRIS MICHELLE , OHLMEYER MICHAEL J , ZHANG CHONGWU , ZHANG RUI
IPC分类号： C07D401/14 , A61K31/4155 , A61K31/4196 , A61K31/422 , A61K31/427 , A61K31/506 , A61P13/12 , A61P29/00 , A61P35/00 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14
CPC分类号： C07D413/14 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/14
摘要： Compounds of the formula (I) are disclosed. The compounds are CCR1 antagonists which are useful for the treatment and prevention of inflammatory and autoimmune diseases. Other embodiments are also disclosed.
摘要翻译： 公开了式（I）的化合物。 这些化合物是可用于治疗和预防炎性和自身免疫性疾病的CCR1拮抗剂。 还公开了其他实施例。
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2.发明申请
公开(公告)号：WO2008011392A3
公开(公告)日：2008-01-24
申请号：PCT/US2007/073656
申请日：2007-07-17
申请人： PHARMACOPEIA, INC. , MERRITT, James Robert , JAMES, Ray A. , LIU, Jinqi , LIU, Ruiyan , LOWRIE, Jeffrey , MORRIS, Michelle , ROUGHTEN, Andrew , PARADKAR, Vidyadhar , ZHANG, Chongwu , ZHANG, Rui , OHLMEYER, Michael , HO, Koc Kan
发明人： MERRITT, James Robert , JAMES, Ray A. , LIU, Jinqi , LIU, Ruiyan , LOWRIE, Jeffrey , MORRIS, Michelle , ROUGHTEN, Andrew , PARADKAR, Vidyadhar , ZHANG, Chongwu , ZHANG, Rui , OHLMEYER, Michael , HO, Koc Kan
IPC分类号： C07D207/16 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , A61K31/401 , A61P29/00
摘要： Compounds of the formulae (I) and (II) are disclosed. The compounds are CCRl antagonists which are useful for the treatment and prevention of inflammatory and autoimmune diseases. Other embodiments are also disclosed.
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3.发明申请
公开(公告)号：WO2009082526A3
公开(公告)日：2009-07-02
申请号：PCT/US2008/078743
申请日：2008-10-03
申请人： PHARMACOPEIA, INC. , PARADKAR, Vidyadhar, M. , BRESCIA, Marc , JAMES, Ray , LIU, Jinqi , MERRITT, James, Robert , MORRIS, Michelle , OHLMEYER, Michael, J. , ZHANG, Chongwu , ZHANG, Rui
发明人： PARADKAR, Vidyadhar, M. , BRESCIA, Marc , JAMES, Ray , LIU, Jinqi , MERRITT, James, Robert , MORRIS, Michelle , OHLMEYER, Michael, J. , ZHANG, Chongwu , ZHANG, Rui
IPC分类号： C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , A61K31/422 , A61K31/4155 , A61K31/506 , A61K31/427 , A61K31/4196 , A61P29/00 , A61P35/00 , A61P13/12
摘要： Compounds of the formula (I) are disclosed. The compounds are CCR1 antagonists which are useful for the treatment and prevention of inflammatory and autoimmune diseases. Other embodiments are also disclosed.
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4.发明申请PROLINE UREA CCR1 ANTAGONISTS FOR THE TREATMENT OF AUTOIMMUNE DISEASES OR INFLAMMATION 审中-公开PROLINE UREA CCR1治疗自身免疫性疾病或炎症的拮抗剂
公开(公告)号：WO2008011392A8
公开(公告)日：2008-07-24
申请号：PCT/US2007073656
申请日：2007-07-17
申请人： PHARMACOPEIA INC , MERRITT JAMES ROBERT , JAMES RAY A , LIU JINQI , LIU RUIYAN , LOWRIE JEFFREY , MORRIS MICHELLE , ROUGHTEN ANDREW , PARADKAR VIDYADHAR , ZHANG CHONGWU , ZHANG RUI , OHLMEYER MICHAEL , HO KOC KAN
发明人： MERRITT JAMES ROBERT , JAMES RAY A , LIU JINQI , LIU RUIYAN , LOWRIE JEFFREY , MORRIS MICHELLE , ROUGHTEN ANDREW , PARADKAR VIDYADHAR , ZHANG CHONGWU , ZHANG RUI , OHLMEYER MICHAEL , HO KOC KAN
IPC分类号： C07D207/16 , A61K31/401 , A61P29/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号： C07D207/16 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Compounds of the formulae (I) and (II) are disclosed. The compounds are CCRl antagonists which are useful for the treatment and prevention of inflammatory and autoimmune diseases. Other embodiments are also disclosed.
摘要翻译： 公开了式（I）和（II）的化合物。 这些化合物是可用于治疗和预防炎性和自身免疫性疾病的CCR1拮抗剂。 还公开了其他实施例。
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5.发明申请NOVEL FATTY ACID-SALICYLATE CONJUGATES WITH ENHANCED THERAPEUTIC PROPERTIES 审中-公开新型脂肪酸 - 磺酸酯与增强的治疗性质结合
公开(公告)号：WO2014004951A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/048425
申请日：2013-06-28
CPC分类号： A61K47/48038 , A61K31/616 , A61K47/542
摘要： The invention provides compositions and methods for treating or preventing cancer with an inventive composition. 'The invention relates to the fields of biomedicine, pharmacology, and molecular biology.
摘要翻译： 本发明提供用本发明组合物治疗或预防癌症的组合物和方法。 本发明涉及生物医学，药理学和分子生物学领域。
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6.发明申请PROLINE UREA CCR1 ANTAGONISTS FOR AUTOIMMUNE DISEASES & INFLAMMATION 审中-公开PROLINE UREA CCR1 ANTAGONISTS FOR AUTOIMMUNE DISEASES＆INFLAMMATION
公开(公告)号：WO2008011392A2
公开(公告)日：2008-01-24
申请号：PCT/US2007/073656
申请日：2007-07-17
申请人： PHARMACOPEIA, INC. , MERRITT, James Robert , JAMES, Ray A. , LIU, Jinqi , LIU, Ruiyan , LOWRIE, Jeffrey , MORRIS, Michelle , ROUGHTEN, Andrew , PARADKAR, Vidyadhar , ZHANG, Chongwu , ZHANG, Rui , OHLMEYER, Michael , HO, Koc Kan
发明人： MERRITT, James Robert , JAMES, Ray A. , LIU, Jinqi , LIU, Ruiyan , LOWRIE, Jeffrey , MORRIS, Michelle , ROUGHTEN, Andrew , PARADKAR, Vidyadhar , ZHANG, Chongwu , ZHANG, Rui , OHLMEYER, Michael , HO, Koc Kan
IPC分类号： C07D207/16 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14
CPC分类号： C07D207/16 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Compounds of the formulae (I) and (II) are disclosed. The compounds are CCRl antagonists which are useful for the treatment and prevention of inflammatory and autoimmune diseases. Other embodiments are also disclosed.
摘要翻译： 公开了式（I）和（II）的化合物。 这些化合物是可用于治疗和预防炎性和自身免疫性疾病的CCR1拮抗剂。 还公开了其他实施例。
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7.发明申请3,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS 审中-公开作为CXC-CHEMOKINE受体配体的3,4-二取代的环己基-1,2-二酮
公开(公告)号：WO2008005570A1
公开(公告)日：2008-01-10
申请号：PCT/US2007/015671
申请日：2007-07-05
申请人： SCHERING CORPORATION , PHARMACOPEIA, INC. , CHAO, Jianhua , CZARNIECKI, Michael, F. , HE, Zhenmin , LAI, Gaifa , MERRITT, James, Robert
IPC分类号： C07D307/52 , A61K31/341 , A61K31/40 , A61P29/00 , A61P35/00
CPC分类号： C07D405/12 , C07D307/52 , C07D307/56
摘要： Disclosed are novel cyclobutenedione Compounds comprising a cycloclobutenedione ring, a substituted phenyl ring, and a -CH(C 2 H 5 )-furan moiety. The phenyl ring and the -CH(C 2 H 5 )-furan moiety are each bound to the cyclobutenedione ring through a -NH- moiety. Also disclosed are uses o Compounds for the manufacture of a medicament for treating chemokine mediated diseases (e.g., cancer, COPD, acute and chronic inflammatory disorders, psoriasis, cystic fibrosis, and asthma).
摘要翻译： 公开了新的环丁烯二酮包含环多烯二酮环，取代的苯环和-CH（C 2 H 5 H 5） - 呋喃部分的化合物。 苯环和-CH（C 2 H 5 H 5） - 呋喃部分各自通过-NH-部分与环丁烯二酮环结合。 还公开了用于制备用于治疗趋化因子介导的疾病（例如癌症，COPD，急性和慢性炎性疾病，牛皮癣，囊性纤维化和哮喘）的药物的化合物。
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