公开(公告)号：WO2019082169A1

公开(公告)日：2019-05-02

申请号：PCT/IB2018/058415

申请日：2018-10-27

Applicant: GOURABI, Hamid ,  MOBEDI, Hamid ,  MIRZAEI, Siyavash ,  KHEZLI, Sakineh

Inventor： GOURABI, Hamid ,  MOBEDI, Hamid ,  MIRZAEI, Siyavash ,  KHEZLI, Sakineh

IPC: G01N33/15

CPC classification number: G01N33/15 ,  B01L7/02 ,  B01L7/525 ,  B01L2200/0621 ,  B01L2300/0681 ,  B01L2300/087 ,  B01L2400/0457 ,  B01L2400/0487

Abstract: A method and apparatus for drug dissolution testing may include an overflow vessel with an overflow outlet port at a predetermined height from a bottom of the overflow vessel, a first water bath submerging the overflow vessel and configured to keep a temperature of the overflow vessel at a first predetermined temperature, a pressurized vessel containing a dissolution medium, a second water bath submerging the pressurized vessel and configured to keep the dissolution medium at a second predetermined temperature, a dissolution medium path with an output end connected in fluid communication with the flow cell and an input end attached in fluid communication to the pressurized vessel, where the dissolution medium path may transfer the dissolution medium from the pressurized vessel into the flow cell, a collection vessel connected to the overflow outlet port of the flow cell, and a third water bath submerging the collection vessel and configured to keep the collection vessel at a third predetermined temperature.

公开(公告)号：WO2018046987A1

公开(公告)日：2018-03-15

申请号：PCT/IB2016/055415

申请日：2016-09-12

Applicant: BARIKANI, Hamid Reza ,  ROKN, Amir Reza ,  MOBEDI, Hamid ,  BAHADOR, Abbas Bahador

Inventor： BARIKANI, Hamid Reza ,  ROKN, Amir Reza ,  MOBEDI, Hamid ,  BAHADOR, Abbas Bahador

IPC: A61K31/00

Abstract: The embodiments herein disclose method of synthesizing a composition of controlled drug (antibiotics) release for the treatment of peri-implantitis and periodontal infections which damages the Osseo-integrated dental implant and generates a loss of supporting bone. The combination of metronidazole and amoxicillin overcomes a wide range of pathogens associated with peri-implantitis. A localized biodegradable controlled drug delivery composition is synthesized for treatment of dental and implants infections (peri-implantisis). The system comprises polymer and antibiotics (metronidazole and amoxicillin). The system burst releases antibiotics in the first hours after administration, followed by a controlled release of the antibiotics for a time period up of 3 weeks. The antibiotic concentration is maintained in a suitable therapeutic range. An analysis after 14 days illustrates the elimination of the bacterial biofilm and bactericidal property of the composition.

Abstract translation: 这里的实施方案公开了合成用于治疗种植体周围炎和牙周感染的受控药物（抗生素）释放组合物的方法，所述组合物损伤Osseo整合的牙植入体并且产生支持骨的损失。 甲硝唑和阿莫西林的组合克服了与种植体周围炎相关的各种病原体。 合成用于治疗牙科和植入物感染（植入周围）的局部可生物降解的受控药物递送组合物。 该系统包含聚合物和抗生素（甲硝唑和阿莫西林）。 在给药后的头几个小时，系统爆发释放抗生素，随后控制释放抗生素达3周。 抗生素浓度维持在合适的治疗范围内。 14天后的分析表明消除了组合物的细菌生物膜和杀菌性质。