公开(公告)号：WO1997034905A1

公开(公告)日：1997-09-25

申请号：PCT/EP1997001286

申请日：1997-03-12

Applicant: SMITHKLINE BEECHAM PLC ,  MORGAN, Helen, Kate, Ann ,  WARD, Robert, William ,  THOMPSON, Mervyn

Inventor： SMITHKLINE BEECHAM PLC

IPC: C07F09/53

CPC classification number: C07F9/65685 ,  C07F9/5304

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein, R represents an aryl group optionally substituted with one, two or three substituents selected from the list consisting of: hydroxy, hydroxymethyl, nitro, amino, alkylamino, dialkylamino, alkylsulphonamido wherein the alkyl group is optionally substituted with one, two or three substituents selected from: halogen, haloalkyl, hydroxy, alkoxy, or arylsulphonamido wherein the aryl group is optionally substituted, providing that R is not 3-methylsulphonylaminophenyl when X represents O or S; R and R each independently represent hydrogen or an alkyl group; R represents a moiety of formula (a), wherein R and R each independently represents hydrogen, alkyl, cycloalkyl, aryl or aralkyl or R together with R represent -(CH2)n- wherein n is 3, 4 or 5; and R represents hydrogen, halogen, alkyl or alkoxy; a pharmaceutical composition comprising such a compound, a process for preparing such a compound and the use of such a compound and composition in medicine.

Abstract translation: 式（I）化合物或其药学上可接受的盐或其药学上可接受的溶剂合物，其中R 0表示任选被一个，两个或三个选自以下的取代基取代的芳基：羟基，羟甲基 硝基，氨基，烷基氨基，二烷基氨基，烷基磺酰氨基，其中烷基任选被一个，两个或三个选自以下的取代基取代：卤素，卤代烷基，羟基，烷氧基或芳基磺酰氨基，其中芳基任选地被取代，条件是R 当X表示O或S时，不是3-甲基磺酰基氨基苯基; R 1和R 1a各自独立地表示氢或烷基; R 2表示式（a）的部分，其中R 4和R 5各自独立地表示氢，烷基，环烷基，芳基或芳烷基或R 5与R 4一起代表 - （CH 2 ）n-，其中n为3,4或5; R 3表示氢，卤素，烷基或烷氧基; 包含这种化合物的药物组合物，制备这种化合物的方法以及这种化合物和组合物在医药中的用途。

公开(公告)号：WO1995034545A1

公开(公告)日：1995-12-21

申请号：PCT/EP1995002076

申请日：1995-05-31

Applicant: SMITHKLINE BEECHAM PLC ,  CHAN, Wai, Ngor ,  MORGAN, Helen, Kate, Ann ,  THOMPSON, Mervyn ,  EVANS, John, Morris

Inventor： SMITHKLINE BEECHAM PLC

IPC: C07D311/68

CPC classification number: C07D405/12 ,  C07D311/68 ,  C07D409/12

Abstract: The invention relates to certain cis and trans benzopyrans having substituted benzamides at position C-4 and to their use in treating and/or preventing certain CNS disorders.

Abstract translation: 本发明涉及在C-4位具有取代苯甲酰胺的某些顺式和反式苯并吡喃及其在治疗和/或预防某些CNS障碍中的用途。