-
公开(公告)号：WO2009052429A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/080371
申请日：2008-10-17
CPC分类号： C01G1/02 , C01G5/00 , C01G9/02 , C01G23/047 , C01G23/053 , C01G25/02 , C01G31/02 , C01G35/00 , Y10T428/31504 , Y10T428/31598
摘要： A composition and method for coatings (120) applied to articles (100), are disclosed. A composition can be applied onto a surface of an object, the composition comprising a polymer and a metal alkoxide precursor. A metal oxide is formed from the metal oxide precursor by a process comprising hydrolyzing the metal oxide precursor followed by heating the coated article. The coated articles comprise medical devices including medical implants.
摘要翻译： 公开了用于制品（100）的涂层（120）的组合物和方法。 组合物可以施加到物体的表面上，该组合物包含聚合物和金属醇盐前体。 金属氧化物由金属氧化物前体通过包括水解金属氧化物前体的方法形成，然后加热涂覆的制品。 涂覆制品包括医疗装置，包括医疗植入物。
-
公开(公告)号：WO2007087402A3
公开(公告)日：2008-12-24
申请号：PCT/US2007002050
申请日：2007-01-24
申请人： UNIV BROWN , MORGAN JEFFREY R , CHAI PETER , NAPOLITANO ANTHONY , MATHIOWITZ EDITH , DEAN DYLAN
CPC分类号： C12M25/00 , B33Y80/00 , C12M21/08 , C12M23/12 , C12M25/14 , C12N5/0012 , C12N5/0062 , C12N2533/40 , C12N2533/74
摘要： The invention is a cell aggregation device comprising a hydrogel substrate having at least one, preferably a plurality, of cell-repellant compartments recessed into the uppermost surface. Each compartment is composed of an upper cell suspension seeding chamber having an open uppermost portion and a bottom portion, and one, or more than one, lower cell aggregation recess connected to the bottom portion of the upper cell suspension seeding chamber by a port. The diameter of the port may be fully contiguous with the walls of the chambers and walls of the recesses, or the diameter of the port may be more narrow than the walls of the chamber but fully contiguous with the walls of the recesses or more narrow than both the walls of the chamber and the walls of the recesses. The upper cell suspension seeding chambers are formed and positioned to funnel the cells into the lower cell aggregation recesses through gravitational force. The aggregation recesses are formed and positioned to promote cellular aggregation by coalescing cells into a finite region of minimum gravitational energy, increasing intercellular contact and minimizing or preventing cell adherence to the substrate. A device for encapsulating aggregates of live cells is provided. The device comprises (i) a biocompatible, bio-sustainable substrate having a cell- encapsulating face composed of one or more biocompatible, bio-sustainable, spaced-apart, cell-encapsulating compartments extending therefrom and (ii) a coating layer composed of a biocompatible, bio-sustainable polymer that completely surrounds the substrate and the cell-encapsulating compartments. A method for making the device is also provided.
摘要翻译： 本发明是一种细胞聚集装置，其包括具有至少一个，优选多个凹陷到最上表面的细胞排斥隔室的水凝胶基底。 每个隔室由具有开口最上部分和底部的上部细胞悬浮播种室组成，以及通过端口连接到上部细胞悬浮播种室的底部的一个或多于一个下部细胞聚集凹部。 端口的直径可以与腔室的壁和凹部的壁完全邻接，或者端口的直径可以比室的壁更窄，但是与凹部的壁完全邻接或更窄 房间的墙壁和凹槽的墙壁。 形成并定位上部细胞悬浮播种室，通过重力将细胞漏入下部细胞聚集凹槽。 形成和定位聚集凹槽以通过将细胞聚结成最小重力能的有限区域，增加细胞间接触并最小化或防止细胞粘附于基底来促进细胞聚集。 提供了用于封装活细胞聚集体的装置。 该装置包括（i）生物相容的生物可持续的底物，其具有由一个或多个生物相容性，生物可持续的间隔开的细胞包封的隔室组成的细胞封装面，所述细胞封装的区域从其延伸，以及（ii）由 生物相容的，生物可持续的聚合物，其完全包围底物和细胞封装的隔室。 还提供了制造该装置的方法。
-
公开(公告)号：WO2007087402A2
公开(公告)日：2007-08-02
申请号：PCT/US2007/002050
申请日：2007-01-24
申请人： BROWN UNIVERSITY , MORGAN, Jeffrey, R. , CHAI, Peter , NAPOLITANO, Anthony , MATHIOWITZ, Edith , DEAN, Dylan
IPC分类号： C12M3/00
CPC分类号： C12M25/00 , B33Y80/00 , C12M21/08 , C12M23/12 , C12M25/14 , C12N5/0012 , C12N5/0062 , C12N2533/40 , C12N2533/74
摘要： The invention is a cell aggregation device comprising a hydrogel substrate having at least one, preferably a plurality, of cell-repellant compartments recessed into the uppermost surface. Each compartment is composed of an upper cell suspension seeding chamber having an open uppermost portion and a bottom portion, and one, or more than one, lower cell aggregation recess connected to the bottom portion of the upper cell suspension seeding chamber by a port. The diameter of the port may be fully contiguous with the walls of the chambers and walls of the recesses, or the diameter of the port may be more narrow than the walls of the chamber but fully contiguous with the walls of the recesses or more narrow than both the walls of the chamber and the walls of the recesses. The upper cell suspension seeding chambers are formed and positioned to funnel the cells into the lower cell aggregation recesses through gravitational force. The aggregation recesses are formed and positioned to promote cellular aggregation by coalescing cells into a finite region of minimum gravitational energy, increasing intercellular contact and minimizing or preventing cell adherence to the substrate. A device for encapsulating aggregates of live cells is provided. The device comprises (i) a biocompatible, bio-sustainable substrate having a cell- encapsulating face composed of one or more biocompatible, bio-sustainable, spaced-apart, cell-encapsulating compartments extending therefrom and (ii) a coating layer composed of a biocompatible, bio-sustainable polymer that completely surrounds the substrate and the cell-encapsulating compartments. A method for making the device is also provided.
摘要翻译： 本发明是一种细胞聚集装置，其包括具有至少一个，优选多个凹陷到最上表面的细胞排斥隔室的水凝胶基底。 每个隔室由具有开口最上部分和底部的上部细胞悬浮播种室组成，以及通过端口连接到上部细胞悬浮播种室的底部的一个或多于一个下部细胞聚集凹部。 端口的直径可以与腔室的壁和凹部的壁完全邻接，或者端口的直径可以比室的壁更窄，但是与凹部的壁完全邻接或更窄 房间的墙壁和凹槽的墙壁。 形成并定位上细胞悬浮播种室，以通过重力将细胞漏入下细胞聚集凹槽。 形成和定位聚集凹槽以通过将细胞聚结成最小引力能的有限区域，增加细胞间接触并最小化或防止细胞粘附于基底来促进细胞聚集。 提供了用于封装活细胞聚集体的装置。 该装置包括（i）生物相容的生物可持续的基质，其具有由一个或多个生物相容性，生物可持续的间隔开的细胞包封的隔室组成的细胞封装面，所述细胞封装的区域从其延伸，和（ii）由 生物相容的，生物可持续的聚合物，其完全包围底物和细胞封装隔室。 还提供了制造该装置的方法。
-
-
搜索结果
3 条记录 (耗时 0.011 秒)
