公开(公告)号：WO2004074320A2

公开(公告)日：2004-09-02

申请号：PCT/US2004/004730

申请日：2004-02-17

Applicant: SAGRES DISCOVERY, INC. ,  MORRIS, David, W. ,  MORRIS, David, W. ,  MALANDRO, Marc, S.

Inventor： MORRIS, David, W. ,  MORRIS, David, W. ,  MALANDRO, Marc, S.

IPC: C07K14/47

CPC classification number: G01N33/57492 ,  A61K39/00 ,  C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57426

Abstract: The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.

Abstract translation: 本发明涉及用于检测，诊断和治疗癌症，特别是淋巴瘤的新型序列。 本发明提供了表达与癌症相关的癌症相关（CA）多核苷酸序列。 本发明提供了与癌症相关的CA多肽，其存在于细胞表面上并且呈现针对癌症的新型治疗靶标。 本发明进一步提供了用于检测癌症的诊断组合物和方法。 本发明提供了对CA多肽特异性的单克隆和多克隆抗体。 本发明还提供了用于筛选，预防和治疗癌症的诊断工具和治疗组合物和方法。

公开(公告)号：WO2016094631A1

公开(公告)日：2016-06-16

申请号：PCT/US2015/064944

申请日：2015-12-10

Applicant: PT TECH, INC. ,  CLAPP, Timothy A. ,  COLE, Richard E. ,  FARWELL, David A. ,  NAUMOFF, Tyler A. ,  MORRIS, David J.

Inventor： CLAPP, Timothy A. ,  COLE, Richard E. ,  FARWELL, David A. ,  NAUMOFF, Tyler A. ,  MORRIS, David J.

IPC: F16D13/72 ,  F16D25/062 ,  F16D67/02 ,  F16D11/00 ,  F16D13/00

CPC classification number: F16D13/38 ,  F16D13/70 ,  F16D13/74 ,  F16D25/0635 ,  F16D25/0638 ,  F16D48/06 ,  F16D67/02 ,  F16D2300/0212 ,  F16D2300/18 ,  F16D2300/22

Abstract: A self-contained clutch for diesel engines for off-highway implementation is provided. A stationary friction disc, pressure plate and endplate sandwich a pair of rotating separator discs. Attenuation of vibration damping of the rotator discs may be achieved by a centrifugal weight. A pulse-width-modulated DC motor or valve is employed in association with a hydraulic actuator to control pressure to the clutch piston. An RFID tag uniquely identifies the nature and parameters of the clutch itself and is associated with the clutch such that the controller can most efficiently operate the clutch. Heat is dissipated by an oil pump servicing the support bearings and/or by the integration of a centrifugal fan into the heat disc stack.

Abstract translation: 提供了用于非公路实施的用于柴油发动机的独立离合器。 固定摩擦盘，压板和端板夹着一对旋转分离盘。 旋转盘的振动衰减的衰减可以通过离心重量来实现。 与液压致动器相关联地使用脉冲宽度调制的DC电动机或阀，以控制离合器活塞的压力。 RFID标签唯一地识别离合器本身的性质和参数，并且与离合器相关联，使得控制器能够最有效地操作离合器。 热量通过维修支撑轴承的油泵和/或将离心风扇整合到热盘堆中而消散。

公开(公告)号：WO2015112867A1

公开(公告)日：2015-07-30

申请号：PCT/US2015/012692

申请日：2015-01-23

Applicant: MORRIS, David, R.

Inventor： MORRIS, David, R.

IPC: A47K10/22 ,  A47K10/32 ,  A47K10/38

CPC classification number: A47K10/16 ,  A47K10/38 ,  A47K13/22 ,  B65H18/28 ,  B65H2701/1924

Abstract: Toilet paper rolls are provided with alternating indentions in the left and right sides of the toilet paper sheet wherein the opposite side will retain the straight shape of a normal toilet paper roll. When multiple sheets are folded, the effective area is the same as "normal" toilet paper width. From this, toilet paper sheets may be produced with less material while maintaining wiping performance. For use as a covering for an oval toilet seat, coverage is improved.

Abstract translation: 卫生纸卷在卫生纸的左侧和右侧设置有交替的压痕，其中相对侧将保持普通卫生纸卷的直线形状。 当折叠多张纸时，有效面积与“正常”卫生纸宽度相同。 由此，可以以较少的材料制造卫生纸，同时保持擦拭性能。 用作椭圆形马桶座圈的覆盖物，覆盖率得到改善。

公开(公告)号：WO2014075078A1

公开(公告)日：2014-05-15

申请号：PCT/US2013/069700

申请日：2013-11-12

Applicant: HACH COMPANY ,  HERTEL, Matthew P. ,  MORRIS, David A.N.

Inventor： HERTEL, Matthew P. ,  MORRIS, David A.N.

IPC: G01N21/78 ,  G01N21/80 ,  G01N31/22

CPC classification number: G01N33/18 ,  G01N21/293 ,  G01N21/78 ,  G01N21/80 ,  G01N21/8483 ,  G01N31/22 ,  G01N2021/7759 ,  G01N2021/7793 ,  G01N2021/8488

Abstract: A species test wand (10) for liquids, wherein a user is informed whether the concentration of a species is high, at an acceptable level, or low by a comparison of the color of the wand after exposure to the liquid (24) with nearby labeled colored boxes (18, 20, 22) integral with the wand, is described. Tests include liquid evaluation for chlorine, pH and total alkalinity, as examples.

Abstract translation: 用于液体的物种测试棒（10），其中通过在暴露于具有附近的液体（24）之后的棒的颜色的比较来通知用户浓度是否高，处于可接受水平或低的用户 描述了与魔杖整合的标记的彩色盒子（18,20,22）。 测试包括对氯，pH和总碱度的液体评估，例如。

公开(公告)号：WO2011092454A1

公开(公告)日：2011-08-04

申请号：PCT/GB2011/000070

申请日：2011-01-21

Applicant: GYRUS MEDICAL LIMITED ,  BENN, Christopher Charles ,  HUMBLE, Robert C. ,  MORRIS, David W. ,  NEWTON, Michael David ,  FORD, Andrew John

Inventor： BENN, Christopher Charles ,  HUMBLE, Robert C. ,  MORRIS, David W. ,  NEWTON, Michael David ,  FORD, Andrew John

IPC: A61B18/14

CPC classification number: A61B18/14 ,  A61B2018/00589 ,  A61B2018/00601 ,  A61B2018/124 ,  A61B2018/1467

Abstract: An electrosurgical instrument is provided for the treatment of tissue, the instrument comprising an instrument shaft (10) having a longitudinal axis, and an electrode assembly at one end of the shaft. The electrode assembly comprises first and second active electrodes (11, 14) and at least one return electrode (25). The first and second active electrodes (11, 14) each have an exposed surface to treat tissue disposed laterally of the longitudinal axis at a first radial an a second radial position with respect to the instrument shaft. The instrument has a first set of connections by which the first active electrode (11) can be placed in circuit with the return electrode (25), and a second set of connections by which the second active electrode (14) can be placed in circuit with the return electrode (25).

Abstract translation: 提供用于治疗组织的电外科器械，该仪器包括具有纵向轴线的器械轴（10）和在轴的一端的电极组件。 电极组件包括第一和第二有源电极（11,14）和至少一个返回电极（25）。 第一和第二有源电极（11,14）各自具有暴露表面，以处理相对于仪器轴的第一径向处于纵向轴线侧向设置的第二径向位置处的组织。 仪器具有第一组连接，通过该第一组连接，第一有源电极（11）可以与返回电极（25）放置在电路中，以及第二组连接，第二有源电极（14）可以被放置在电路 与返回电极（25）。

公开(公告)号：WO2010144475A1

公开(公告)日：2010-12-16

申请号：PCT/US2010/037808

申请日：2010-06-08

Applicant: BUCKEYE TECHNOLOGIES INC. ,  BOEHMER, Brian, E. ,  MCGEE, Kathy ,  MORRIS, David ,  WILLCUTT, Jim ,  MOOSE, Ranald, Timothy ,  BAILEY, Rick ,  BOOKER, Richard

Inventor： BOEHMER, Brian, E. ,  MCGEE, Kathy ,  MORRIS, David ,  WILLCUTT, Jim ,  MOOSE, Ranald, Timothy ,  BAILEY, Rick ,  BOOKER, Richard

IPC: D04H1/64 ,  D21H21/28

CPC classification number: D04H1/64 ,  D21H21/20 ,  D21H21/28 ,  Y10T442/2098 ,  Y10T442/277

Abstract: The present invention relates to a process for the dyeing of cellulosic fibers in the form of a comminution sheet to produce a dyed cellulose pulp comminution sheet with high moisture content. The dyed cellulose comminution sheet contains (a) a cellulose pulp comminution sheet having a cellulose content of from about 60 weight percent to about 99.9 weight percent cellulose based on the total weight of solids in the cellulose pulp comminution sheet, and a density of from about 0.3 g/cm3 to about 0.95 g/cm3; (b) a moisture content of from about 25 weight percent to about 55 weight percent, based on the total weight of the dyed cellulose comminution sheet, wherein the moisture content does not exceed bleed point of the comminution sheet; and (c) a dye.

Abstract translation: 本发明涉及一种以粉碎形式染色纤维素纤维的方法，以生产具有高水分含量的染色纤维素纸浆粉碎片。 染色的纤维素粉碎片材包含（a）纤维素纸浆粉碎片材，其纤维素含量基于纤维素纸浆粉碎片材中固体的总重量为约60重量％至约99.9重量％的纤维素，密度为约 0.3g / cm 3至约0.95g / cm 3; （b）基于染色的纤维素粉碎片的总重量，约25重量％至约55重量％的水分含量，其中水分含量不超过粉碎片的渗色点; 和（c）染料。

公开(公告)号：WO2008147603A3

公开(公告)日：2009-02-05

申请号：PCT/US2008061061

申请日：2008-04-21

Applicant: S D M H PTY LTD ,  DANIEL STEVEN A ,  MORRIS DAVID L ,  LEE KEE SEIN

Inventor： DANIEL STEVEN A ,  MORRIS DAVID L ,  LEE KEE SEIN

IPC: A61B18/14

CPC classification number: A61B18/148 ,  A61B18/1477 ,  A61B18/1487 ,  A61B2018/00267

Abstract: A tissue ablation system including numerous components and methods is described herein for encircling target tissue and generating tissue ablation volumes in various biological tissues. The biological tissue includes tissue of a variety of organs of the human body including the liver, spleen, kidney, lung, breast and other organs, but is not so limited. The tissue ablation device comprises an energy source and at least one trocar coupled to the energy source, the trocar having a body, a proximal end, and a distal end. The trocar carries an electrode array that comprises a plurality of electrodes, each electrode of the plurality of electrodes is configured to extend from the trocar when moved from a retracted state to a deployed state, and to have at least one radius of curvature in the deployed state so that the electrode array forms a series of shaped electrodes in the deployed state.

Abstract translation: 本文描述了包括许多组分和方法的组织消融系统，用于环绕靶组织并在各种生物组织中产生组织消融体积。 生物组织包括人体各种器官的组织，包括肝，脾，肾，肺，乳腺和其他器官，但不限于此。 组织消融装置包括能量源和耦合到能量源的至少一个套管针，套管针具有主体，近端和远端。 套针针携带包括多个电极的电极阵列，多个电极中的每个电极被配置成当套管针从缩回状态移动到展开状态时延伸，并且在展开的部分中具有至少一个曲率半径 使得电极阵列形成处于展开状态的一系列成形电极。

公开(公告)号：WO2007146194A3

公开(公告)日：2008-10-16

申请号：PCT/US2007013630

申请日：2007-06-07

Applicant: POSSIS MEDICAL INC ,  BONNETTE MICHAEL JOHN ,  THOR ERIC JOEL ,  WEISEL STEPHEN EARL ,  MORRIS DAVID BRIAN

Inventor： BONNETTE MICHAEL JOHN ,  THOR ERIC JOEL ,  WEISEL STEPHEN EARL ,  MORRIS DAVID BRIAN

IPC: A61B17/20 ,  A61B17/22 ,  A61B17/32

CPC classification number: A61B17/32075 ,  A61B17/32037 ,  A61B17/320708 ,  A61B17/320783 ,  A61B2017/003 ,  A61B2017/2927 ,  A61B2017/320791

Abstract: An atherectomy system having a variably exposed cutter wherein a distally located positionable tip closely associated with the cutter and a high pressure fluid jet emanator can be variably and angularly deployed about a hinge mechanism subsequent to entry into the vasculature. The fixed cutter slices or parts atheromatous material and/or thrombotic material from a blood vessel for interaction with high pressure jets to macerate, break up or otherwise reduce the materials for evacuation from the site.

Abstract translation: 具有可变暴露的切割器的粥样斑块切除术系统，其中与切割器紧密相关的远侧定位的尖端和高压流体喷射发生器可以在进入脉管系统之后围绕铰链机构可变地和角度地展开。 来自血管的固定的切割片或部分动脉粥样化材料和/或血栓形成材料用于与高压射流相互作用以浸没，分解或以其他方式减少用于从该部位排出的材料。

公开(公告)号：WO2008027467A1

公开(公告)日：2008-03-06

申请号：PCT/US2007/019066

申请日：2007-08-29

Applicant: MILLIKEN & COMPANY ,  MORRIS, David D.

Inventor： MORRIS, David D.

IPC: G02B6/44 ,  G02B6/46 ,  G02B6/50

CPC classification number: G02B6/4459 ,  H02G1/081 ,  H02G1/086 ,  H02G9/06

Abstract: Flexible textile innerducts are provided with multiple longitudinal chambers. A conduit is formed with the flexible textile innerducts disposed internally. After the conduit is formed with the flexible textile innerducts therein, the conduit is positioned in the use position by burying the conduit or locating it within a body. A cable is disposed within the longitudinal chambers of the flexible innerducts with the use of a pull line or by blowing the cable into the longitudinal chamber.

Abstract translation: 柔性纺织品内层具有多个纵向室。 形成有内部布置的柔性织物内层的导管。 在导管在其中形成有柔性织物内层的导管之后，通过将导管埋入或将其定位在体内而将导管定位在使用位置。 电缆通过使用拉线或通过将电缆吹入纵向室而设置在柔性内层的纵向室内。

公开(公告)号：WO2006078863A2

公开(公告)日：2006-07-27

申请号：PCT/US2006/001972

申请日：2006-01-18

Applicant: DANIEL, Steven, A. ,  MORRIS, David, L. ,  LEE, Kee, Sein

Inventor： DANIEL, Steven, A. ,  MORRIS, David, L. ,  LEE, Kee, Sein

IPC: A61B18/18

CPC classification number: A61B18/148 ,  A61B18/1477 ,  A61B2018/0016 ,  A61B2018/00267 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1475

Abstract: A tissue ablation device and method for tissue ablation are described. The tissue ablation device comprises an energy source and an introducer coupled to the energy source, the introducer having a body, a proximal end, and a distal end. The introducer carries an electrode array that comprises a plurality of electrodes, each electrode of the plurality of electrodes is configured to extend from the body of the introducer when moved from a retracted state to a deployed state. The electrode array is designed to encircle a portion of a target tissue when the electrodes are extended into the deployed state and to form a relatively spherical shaped ablation pattern in a tissue volume surrounding the target tissue when energized by the energy source.

Abstract translation: 描述了用于组织消融的组织消融装置和方法。 组织消融装置包括能量源和耦合到能量源的导引器，导入器具有主体，近端和远端。 引导器携带包括多个电极的电极阵列，多个电极中的每个电极构造成当从缩回状态移动到展开状态时，从引导器的主体延伸。 当电极延伸到展开状态时，电极阵列被设计成环绕目标组织的一部分，并且在被能量源激励时围绕目标组织的组织体积中形成相对球形的消融图案。