公开(公告)号：WO1990008784A1

公开(公告)日：1990-08-09

申请号：PCT/JP1990000141

申请日：1990-02-06

Applicant: TAIHO PHARMACEUTICAL CO., LTD. ,  KOTAI KASEI CO., LTD. ,  FAN, Hui-Zeng ,  YU, Song ,  YAMANAKA, Etsuji ,  NUMATA, Kazuhiro ,  OKA, Toshinori ,  SUZUKI, Norihiko ,  MURANAKA, Yoshiyuki

Inventor： TAIHO PHARMACEUTICAL CO., LTD. ,  KOTAI KASEI CO., LTD.

IPC: C08B37/00

CPC classification number: C08B37/0063

Abstract: This invention relates to a sulfated polysaccharide D-HG, prepared by depolymerizing FGAG (an extract from the parietes of a sea cucumber comprising a sulfated polysaccharide having a heparinlike action) or its salt and having the following physicochemical properties, pharmaceutically acceptable salts thereof, a method for preparing the same, and drugs for treating diffuse intravascular coagulation (DIC) and thrombosis containing the same as the active ingredient: (1) molecular weight: 3000 to 42000 according to HP GPC; (2) form: white, amorphous and highly hygroscopic powder; (3) solubility: soluble in water and insoluble in organic solvents such as ethanol and acetone; (4) specific rotation: (a); (5) color reaction: Elson-Morgan reaction (+); carbozole-sulfuric acid reaction (+); cysteine-sulfuric acid reaction (+); orcinol-hydrochloric acid reaction (+); azure A metachromasia reaction (+); (6) compositional analysis: galactosamine : glucuronic acid : fucose : sulfate radical = 1 : 0.8 ± 0.2 : 0.85 ± 0.15 : 3.4 ± 0.9.

公开(公告)号：WO1984000959A1

公开(公告)日：1984-03-15

申请号：PCT/JP1983000300

申请日：1983-09-06

Applicant: TAIHO PHARMACEUTICAL COMPANY, LIMITED ,  FUJII, Setsuro ,  OGAWA, Kazuo ,  MURANAKA, Yoshiyuki ,  HAMAKAWA, Toshihiro

Inventor： TAIHO PHARMACEUTICAL COMPANY, LIMITED

IPC: C07C143/68

CPC classification number: C07C309/00

Abstract: Sulfonic ester derivatives represented by general formula (I), wherein R1 represents hydrogen, C1-4 alkyl or C$(,3)$-4 alkoxy, A represents (II), (wherein R2 and R3 each represent C1-4 alkyl) or (III), (wherein R4 and R5 each represent C1-4 alkyl, or they may be connected to each other to form C4-6 cycloalkyl together with the adjacent carbon atom), and $(,3)$ represents an integer of 1 to 3, and a process for their preparation.