公开(公告)号：WO2007112757A2

公开(公告)日：2007-10-11

申请号：PCT/DK2007/000177

申请日：2007-04-04

Applicant: ZYMENEX A/S ,  NILSSON, Stefan

Inventor： NILSSON, Stefan

IPC: C07K1/34 ,  C07K1/36 ,  A61K38/43 ,  C12N9/00 ,  A61P25/00

CPC classification number: A61K38/45 ,  A61K38/465 ,  A61K38/47 ,  C07K1/34 ,  C07K1/36 ,  C12N9/1085 ,  C12Y205/01061 ,  C12Y301/06001 ,  C12Y301/06008 ,  C12Y302/01024 ,  C12Y302/01046

Abstract: The present invention comprises a method of concentrating a composition comprising a polypeptide of interest and the use of such a concentrated composition for the treatment of diseases in mammals, in particular by subcutaneous injection.

Abstract translation: 本发明包括浓缩包含感兴趣的多肽的组合物和使用这种浓缩组合物用于治疗哺乳动物疾病，特别是通过皮下注射的方法。

公开(公告)号：WO2003094729A1

公开(公告)日：2003-11-20

申请号：PCT/SE2003/000715

申请日：2003-05-05

Applicant: NILSSON, Stefan

Inventor： NILSSON, Stefan

IPC: A61B5/103

CPC classification number: A61B5/702 ,  A61B5/1073

Abstract: An apparatus for diagnosing the presence of venous disease in the lower extremities of a patient comprises a support for supporting the patient in an upright sitting position and a recumbent sitting position and plethysmographic means applicable to a distal leg portion. The support is disposed displaceable between these positions in either of which it can be secured. A corresponding method is also disclosed.

Abstract translation: 用于诊断患者下肢静脉疾病的存在的装置包括用于将患者支撑在直立坐姿和躺卧座位的支撑件以及适用于远端腿部的体积描记装置。 支撑件可以在这些位置之间移位，在这两个位置之中，它们可以被固定。 还公开了相应的方法。

公开(公告)号：WO2008105696A1

公开(公告)日：2008-09-04

申请号：PCT/SE2007/000202

申请日：2007-03-01

Applicant: GETINGE STERILIZATION AB ,  LARSSON, Joakim ,  PEDERSEN, Bjarne ,  ÅHLUND, Mats-Åke ,  NILSSON, Stefan

Inventor： LARSSON, Joakim ,  PEDERSEN, Bjarne ,  ÅHLUND, Mats-Åke ,  NILSSON, Stefan

IPC: A61L11/00 ,  A61L9/16 ,  B01D35/18

CPC classification number: A61L11/00 ,  A61L2/07 ,  A61L9/16 ,  A61L2202/122

Abstract: The invention discloses a sterilization device (1), to sterilize media, equipment and/or decontamination of waste material, said sterilization device (1) comprising a chamber (2), at least one exhaust line (6) arranged to said chamber (2) and at least one gas generator arranged to said chamber (2), at least two sterile filters (8a, 8b) arranged in series in the exhaust line (6), at least one vacuum means (7) connected to the chamber (2) via said exhaust line (6) and said at least two filters (8a, 8b). At least one heating means (9) is arranged to said exhaust line (6) between said two sterile filters (8a, 8b) in order to vaporize condensate that develops between the filters. Furthermore, it is disclosed a sterilization process for sterilization of media, equipment and/or decontamination of waste material, a vaporizing system (12) of a sterilization device and use of such a vaporizing system (12) in a sterilization device.

Abstract translation: 本发明公开了一种灭菌装置（1），用于消毒废物的介质，设备和/或去污，所述灭菌装置（1）包括一个室（2），至少一个排放管线（6），布置在所述室 ）和布置在所述室（2）上的至少一个气体发生器，至少两个串联布置在排气管线（6）中的无菌过滤器（8a，8b），连接到室（2）的至少一个真空装置 ）通过所述排气管（6）和所述至少两个过滤器（8a，8b）。 至少一个加热装置（9）布置在所述两个无菌过滤器（8a，8b）之间的所述排气管线（6）上，以便蒸发在过滤器之间形成的冷凝物。 此外，公开了用于消毒废物的介质，设备和/或去污的灭菌方法，灭菌装置的蒸发系统（12）以及在消毒装置中使用这种蒸发系统（12）。

公开(公告)号：WO2007112757A3

公开(公告)日：2008-02-28

申请号：PCT/DK2007000177

申请日：2007-04-04

Applicant: ZYMENEX AS ,  NILSSON STEFAN

Inventor： NILSSON STEFAN

IPC: C07K1/34 ,  A61K38/43 ,  A61P25/00 ,  C07K1/36 ,  C12N9/00

CPC classification number: A61K38/45 ,  A61K38/465 ,  A61K38/47 ,  C07K1/34 ,  C07K1/36 ,  C12N9/1085 ,  C12Y205/01061 ,  C12Y301/06001 ,  C12Y301/06008 ,  C12Y302/01024 ,  C12Y302/01046

Abstract: The present invention comprises a method of concentrating a composition comprising a polypeptide of interest and the use of such a concentrated composition for the treatment of diseases in mammals, in particular by subcutaneous injection.

Abstract translation: 本发明包括浓缩包含感兴趣的多肽的组合物和使用这种浓缩组合物用于治疗哺乳动物疾病，特别是通过皮下注射的方法。

公开(公告)号：WO2007071368A1

公开(公告)日：2007-06-28

申请号：PCT/EP2006/012220

申请日：2006-12-19

Applicant: TELEFONAKTIEBOLAGET LM ERICSSON (PUBL) ,  SUNDSTRÖM, Lars ,  NILSSON, Stefan

Inventor： SUNDSTRÖM, Lars ,  NILSSON, Stefan

IPC: H03M3/00

CPC classification number: H03M3/49 ,  H03M3/454 ,  H03M3/486

Abstract: The invention relates to adjusting an input signal level of a Sigma-Delta converter (1020). A control signal (S AGC,control ) indicative of an input signal level to said Sigma-Delta converter (1020) is generated, and the input signal level to said Sigma-Delta converter (1020) is adjusted in dependence of said control signal (S AGC,control )- The control signal (S AGC,control ) is generated as a signal indicating an operating condition of said Sigma-Delta converter (1020). In this way, internal signals from the Sigma-Delta converter can be used to determine the state of the Sigma-Delta converter, i.e. whether it is operating within its operational input range or not, and whether it is close to the limits of the operational input range. This provides a simple, but accurate guidance of an automatic gain control upstream of the Sigma-Delta converter.

Abstract translation: 本发明涉及调整Σ-Δ转换器（1020）的输入信号电平。 产生指示到所述Σ-Δ转换器（1020）的输入信号电平的控制信号（S＆gt; AGC，控制），并且调整到所述Σ-Δ转换器（1020）的输入信号电平 根据所述控制信号（S> AGC，控制） - 产生控制信号（S＆gt; AGC，控制）作为指示所述Σ-Δ的操作条件的信号 转换器（1020）。 这样，Sigma-Delta转换器的内部信号可用于确定Sigma-Delta转换器的状态，即它是否在其运行输入范围内运行，以及是否接近运行的极限 输入范围。 这提供了对Sigma-Delta转换器上游的自动增益控制的简单但准确的指导。

公开(公告)号：WO9617927A3

公开(公告)日：1996-08-29

申请号：PCT/EP9504819

申请日：1995-12-05

Applicant: KAROBIO AB ,  NILSSON STEFAN

Inventor： NILSSON STEFAN

IPC: A61K38/00 ,  C07K14/61 ,  C12N15/67 ,  C12Q1/68 ,  C12N5/10 ,  C12N15/85

CPC classification number: C12Q1/6897 ,  A61K38/00 ,  C07K14/61 ,  C12N15/67

Abstract: The present invention provides a cell line including a first reporter gene arranged to express an assayable first gene product, expression of the first reporter gene being AP-1 mediated, and a second reporter gene arranged to express a second assayable gene product, expression of the second reporter gene being mediated by NFλB. Thus the present invention provides a convenient one cell line-based assay system which can be used to rapidly test a large number of compounds for potential anti-inflammatory activity. According to a further aspect of the invention there is provided a method of testing a compound for both AP1 and NFλB inhibitory activity, the method comprising providing cells in accordance with the first aspect of the invention, stimulating AP1 and NFλB activity in the cells and contacting the cells with the compound to be tested and monitoring expression of the first and second gene products wherein inhibition of AP1 expression of the first gene product, and inhibition of NFλB mediated expression of the second gene product is indicative that the compound has both AP1 and NFλB-inhibitory activity.

公开(公告)号：WO1996017927A2

公开(公告)日：1996-06-13

申请号：PCT/EP1995004819

申请日：1995-12-05

Applicant: KARO BIO AB ,  NILSSON, Stefan

Inventor： KARO BIO AB

IPC: C12N05/10

CPC classification number: C12Q1/6897 ,  A61K38/00 ,  C07K14/61 ,  C12N15/67

Abstract: The present invention provides a cell line including a first reporter gene arranged to express an assayable first gene product, expression of the first reporter gene being AP-1 mediated, and a second reporter gene arranged to express a second assayable gene product, expression of the second reporter gene being mediated by NF kappa B. Thus the present invention provides a convenient one cell line-based assay system which can be used to rapidly test a large number of compounds for potential anti-inflammatory activity. According to a further aspect of the invention there is provided a method of testing a compound for both AP1 and NF kappa B inhibitory activity, the method comprising providing cells in accordance with the first aspect of the invention, stimulating AP1 and NF kappa B activity in the cells and contacting the cells with the compound to be tested and monitoring expression of the first and second gene products wherein inhibition of AP1 expression of the first gene product, and inhibition of NF kappa B mediated expression of the second gene product is indicative that the compound has both AP1 and NF kappa B-inhibitory activity.

Abstract translation: 本发明提供一种细胞系，其包括布置成表达可测定的第一基因产物的第一报道基因，介导的AP-1的第一报道基因的表达，以及排列成表达第二可测定基因产物的第二报道基因， 第二报告基因由NFκB介导。因此，本发明提供了一种方便的一种基于细胞系的测定系统，其可用于快速测试大量化合物用于潜在的抗炎活性。 根据本发明的另一方面，提供了测试AP1和NFκB抑制活性化合物的方法，所述方法包括提供根据本发明第一方面的细胞，其刺激AP1和NFκB活性 细胞并使细胞与待测化合物接触并监测第一和第二基因产物的表达，其中抑制第一基因产物的AP1表达和抑制NFκB介导的第二基因产物的表达表明， 化合物具有AP1和NFκB抑制活性。

公开(公告)号：WO03015345A3

公开(公告)日：2003-05-08

申请号：PCT/EP0208712

申请日：2002-08-05

Applicant: ERICSSON TELEFON AB L M ,  JERLHAGEN SVEN ,  ANEHEM MAGNUS ,  FINDIKLI AYSEGUL ,  NILSSON STEFAN ,  LILLIEHORN BO

Inventor： JERLHAGEN SVEN ,  ANEHEM MAGNUS ,  FINDIKLI AYSEGUL ,  NILSSON STEFAN ,  LILLIEHORN BO

IPC: H04L12/28 ,  H04L12/56

CPC classification number: H04W28/14

Abstract: Synchronous and asynchronous data traffic over multipoint adhoc telecommunication networks is scheduled in frames, and bandwidth in such networks is allocated based on packet type and traffic by a scheduler that points to frame descriptors, or data structures, that define where data is located, what packet type to use for the transmission, etc. The scheduling of reception is implicit, viz., there is always a transmit/receive descriptor pair. The same scheduler can schedule traffic in interconnected networks in which there is a participant, even if the networks are unsynchronized to one another, and the scheduler can schedule connection-setup actions, such as page and inquiry. The scheduler can also schedule non-actions, or inactivity, such as "no operation" and "sleep".

Abstract translation: 多点adhoc电信网络上的同步和异步数据通信被调度为帧，并且这种网络中的带宽由调度器根据包类型和流量分配，该调度器指向定义数据位于何处的帧描述符或数据结构， 类型以用于传输等。接收的调度是隐含的，即始终存在发送/接收描述符对。 即使网络彼此不同步，调度程序也可以调度存在参与者的互连网络中的流量，并且调度程序可以调度连接设置操作，例如页面和查询。 调度程序还可以调度非动作或不活动，如“无操作”和“睡眠”。

公开(公告)号：WO2003015345A2

公开(公告)日：2003-02-20

申请号：PCT/EP2002/008712

申请日：2002-08-05

Applicant: TELEFONAKTIEBOLAGET L M ERICSSON (publ) ,  JERLHAGEN, Sven ,  ANEHEM, Magnus ,  FINDIKLI, Aysegul ,  NILSSON, Stefan ,  LILLIEHORN, Bo

Inventor： JERLHAGEN, Sven ,  ANEHEM, Magnus ,  FINDIKLI, Aysegul ,  NILSSON, Stefan ,  LILLIEHORN, Bo

IPC: H04L12/00

CPC classification number: H04W28/14

Abstract: Synchronous and asynchronous data traffic over multipoint adhoc telecommunication networks is scheduled in frames, and bandwidth in such networks is allocated based on packet type and traffic by a scheduler that points to frame descriptors, or data structures, that define where data is located, what packet type to use for the transmission, etc. The scheduling of reception is implicit, viz., there is always a transmit/receive descriptor pair. The same scheduler can schedule traffic in interconnected networks in which there is a participant, even if the networks are unsynchronized to one another, and the scheduler can schedule connection-setup actions, such as page and inquiry. The scheduler can also schedule non-actions, or inactivity, such as "no operation" and "sleep".

Abstract translation: 通过多点自组织电信网络的同步和异步数据流量被调度为帧，并且这种网络中的带宽基于分组类型和流量由调度器分配，所述调度器指向定义数据位置的位置的数据结构或数据结构，哪些数据包 类型用于传输等。接收调度是隐式的，即始终有一个发送/接收描述符对。 即使网络彼此不同步，相同的调度器也可以在其中存在参与者的互联网络中调度流量，并且调度器可以调度诸如页面和查询之类的连接设置动作。 调度程序还可以安排非操作或不活动，例如“无操作”和“睡眠”。

公开(公告)号：WO1996012011A1

公开(公告)日：1996-04-25

申请号：PCT/EP1995004032

申请日：1995-10-12

Applicant: KARO BIO AB ,  NILSSON, Stefan

Inventor： KARO BIO AB

IPC: C12N05/10

CPC classification number: C12Q1/6897

Abstract: The invention provides a cell line including a first reporter gene arranged to express an assayable first gene product, expression of the first reporter gene being AP-1 mediated, and a second reporter gene arranged to express a second assayable gene product, expression of the second reporter gene being mediated by the glucocorticoid receptor (GR). The invention also provides a method of testing a compound for glucocorticoid-like activity comprising providing cells in accordance with the first aspect of the invention, stimulating AP1 activity in the cells and contacting the cells with the compound and monitoring expression of the first and second gene products.

Abstract translation: 本发明提供了一种细胞系，其包括布置成表达可测定的第一基因产物的第一报道基因，第一报告基因的表达是AP-1介导的，第二报告基因排列成表达第二可测定基因产物，第二报告基因表达第二 报告基因由糖皮质激素受体（GR）介导。 本发明还提供了一种测试糖皮质激素样活性化合物的方法，包括提供根据本发明第一方面的细胞，刺激细胞中的AP1活性并使细胞与化合物接触并监测第一和第二基因的表达 产品。