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28 条记录 (耗时 0.015 秒)

    IL-34 ANTISENSE AGENTS AND METHODS OF USING SAME
    1.
    发明申请
    IL-34 ANTISENSE AGENTS AND METHODS OF USING SAME 审中-公开

    公开(公告)号：WO2021094616A1

    公开(公告)日：2021-05-20

    申请号：PCT/EP2020/082281

    申请日：2020-11-16

    申请人： NOGRA PHARMA LIMITED

    发明人： VITI, Francesca ,  MCNULTY, Marie ,  BELLINVIA, Salvatore

    IPC分类号： C12N15/113 ,  A61K31/7115 ,  A61K31/7125 ,  A61P29/00

    摘要： Disclosed herein are IL-34 inhibitors, including IL-34 antisense oligonucleotide sequences, and methods for treating inflammatory diseases, such as an inflammatory bowel disease, and/or fibrosis, associated with elevated activity or expression of IL-34. Also disclosed are pharmaceutical compositions containing an IL-34 inhibitor, for example, a IL-34 antisense oligonucleotide, useful for treating inflammatory diseases and/or fibrosis and manufacture of medicaments containing a disclosed IL-34 inhibitor to be used in treating inflammatory diseases and/or fibrosis.

    METHODS OF TREATING PULMONARY FIBROSIS
    4.
    发明申请
    METHODS OF TREATING PULMONARY FIBROSIS 审中-公开

    公开(公告)号：WO2022069701A1

    公开(公告)日：2022-04-07

    申请号：PCT/EP2021/077082

    申请日：2021-10-01

    申请人： NOGRA PHARMA LIMITED

    发明人： BELLINVIA, Salvatore ,  VITI, Francesca

    IPC分类号： A61K31/196 ,  A61P11/00

    摘要： The present disclosure relates to methods of preventing the onset of or treating pulmonary fibrosis, e.g., pulmonary fibrosis associated with a coronavirus infection or an aberrant level of ACE2. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a peroxisome proliferator-activated receptor gamma (PPAR-γ) modulator or a pharmaceutically acceptable salt thereof, such as the compound of Formula (I).

    COMPOSITIONS FOR USE IN PREVENTING ACNE
    5.
    发明申请
    COMPOSITIONS FOR USE IN PREVENTING ACNE 审中-公开

    公开(公告)号：WO2020152350A1

    公开(公告)日：2020-07-30

    申请号：PCT/EP2020/051810

    申请日：2020-01-24

    申请人： NOGRA PHARMA LIMITED

    发明人： BELLINVIA, Salvatore ,  VITI, Francesca

    IPC分类号： A61K9/00 ,  A61K9/06 ,  A61P17/10 ,  A61K31/196 ,  A61Q19/00

    摘要： Disclosed herein are methods for preventing acne in a patient comprising administering topically to the patient a composition effective to induce sebocyte differentiation. Also disclosed herein are methods of preventing acne in a patient comprising administering topically to the patient a composition effective to reduce insulin-induced lipoxygenase (LOX) activity and/or inflammatory processes. Also disclosed herein are methods of preventing a disease, condition, or disorder characterized by alteration of sebocyte differentiation, comprising administering topically to a patient a composition effective to induce sebocyte differentiation. The described methods can include administering a composition that includes a therapeutically effective amount of a PPARγ modulator, and a pharmaceutically acceptable excipient.

    FRAGILE X MENTAL RETARDATION PROTEIN INTERFERING OLIGONUCLEOTIDES AND METHODS OF USING SAME
    7.
    发明申请
    FRAGILE X MENTAL RETARDATION PROTEIN INTERFERING OLIGONUCLEOTIDES AND METHODS OF USING SAME 审中-公开

    公开(公告)号：WO2020174023A1

    公开(公告)日：2020-09-03

    申请号：PCT/EP2020/055071

    申请日：2020-02-26

    申请人： NOGRA PHARMA LIMITED

    发明人： VITI, Francesca ,  BELLINVIA, Salvatore

    IPC分类号： C12N15/113 ,  A61K31/7125

    摘要： Disclosed herein are antisense oligonucleotide sequences against fragile X mental retardation protein (FMRP) and methods of using the same for treating bowel diseases such as colorectal cancer and inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis), associated with elevated activity or expression of FMRP. Also disclosed are pharmaceutical compositions containing an FMRP antisense oligonucleotide useful for treating a bowel disease and manufacture of medicaments containing a disclosed FMRP antisense oligonucleotide to be used in treating a bowel disease.