公开(公告)号：WO2012021045A3

公开(公告)日：2012-05-10

申请号：PCT/KR2011005994

申请日：2011-08-16

Applicant: NAT CANCER CT ,  KIM SEOK KI ,  KANG SE HUN ,  KIM SEO IL ,  KIM YOUNG SANG ,  BAEK NAM SUK ,  NOH JIN HEE

Inventor： KIM SEOK KI ,  KANG SE HUN ,  KIM SEO IL ,  KIM YOUNG SANG ,  BAEK NAM SUK ,  NOH JIN HEE

IPC: G01N33/60 ,  A61K51/00 ,  G01N33/52 ,  G21H5/00

CPC classification number: A61K51/081 ,  A61K49/0002 ,  A61K49/0021 ,  A61K49/0034 ,  A61K49/0056 ,  A61K49/006 ,  G01N33/534 ,  G01N2333/765

Abstract: The present invention relates to a sentinel lymph node marker comprising albumin to which a radioactive isotope, one or more dyes selected from near-infrared ray absorbing dyes, and a visible ray absorbing dye are coupled, a preparation method thereof, a kit for preparing the same for multi-mode imaging the sentinel lymph node, and a multi-mode imaging method of the sentinel lymph node using the same. The sentinel lymph node marker of the present invention has a long retention time at a lymph node and enables multi-mode imaging, and thus it is possible to precisely check the sentinel lymph node without a skin incision by ex vivo imaging through a near-infrared image and/or gamma ray image, and it is possible to precisely check the location of the sentinel lymph node with the naked eye when used in conjunction with surgery for removing the checked sentinel lymph node.

Abstract translation: 本发明涉及包含白蛋白的前哨淋巴结标记物，其中放射性同位素，一种或多种选自近红外线吸收染料和可见光吸收染料的染料偶联，其制备方法，用于制备 前哨淋巴结的多模式成像相同，前哨淋巴结的多模式成像方法也是如此。 本发明的前哨淋巴结标记物在淋巴结处具有较长的保留时间，能够实现多模式成像，因此可以通过近红外线的离体成像来精确检查前哨淋巴结，无需皮肤切口 图像和/或γ射线图像，并且当与用于移除检查的前哨淋巴结的手术结合使用时，可以用肉眼精确地检查前哨淋巴结的位置。