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    SENTINEL LYMPH NODE MARKER CAPABLE OF MULTI-MODE IMAGING
    1.
    发明申请
    SENTINEL LYMPH NODE MARKER CAPABLE OF MULTI-MODE IMAGING 审中-公开

    公开(公告)号：WO2012021045A3

    公开(公告)日：2012-05-10

    申请号：PCT/KR2011005994

    申请日：2011-08-16

    Applicant: NAT CANCER CT ,  KIM SEOK KI ,  KANG SE HUN ,  KIM SEO IL ,  KIM YOUNG SANG ,  BAEK NAM SUK ,  NOH JIN HEE

    Inventor： KIM SEOK KI ,  KANG SE HUN ,  KIM SEO IL ,  KIM YOUNG SANG ,  BAEK NAM SUK ,  NOH JIN HEE

    IPC: G01N33/60 ,  A61K51/00 ,  G01N33/52 ,  G21H5/00

    CPC classification number: A61K51/081 ,  A61K49/0002 ,  A61K49/0021 ,  A61K49/0034 ,  A61K49/0056 ,  A61K49/006 ,  G01N33/534 ,  G01N2333/765

    Abstract: The present invention relates to a sentinel lymph node marker comprising albumin to which a radioactive isotope, one or more dyes selected from near-infrared ray absorbing dyes, and a visible ray absorbing dye are coupled, a preparation method thereof, a kit for preparing the same for multi-mode imaging the sentinel lymph node, and a multi-mode imaging method of the sentinel lymph node using the same. The sentinel lymph node marker of the present invention has a long retention time at a lymph node and enables multi-mode imaging, and thus it is possible to precisely check the sentinel lymph node without a skin incision by ex vivo imaging through a near-infrared image and/or gamma ray image, and it is possible to precisely check the location of the sentinel lymph node with the naked eye when used in conjunction with surgery for removing the checked sentinel lymph node.

    Abstract translation: 本发明涉及包含白蛋白的前哨淋巴结标记物，其中放射性同位素，一种或多种选自近红外线吸收染料和可见光吸收染料的染料偶联，其制备方法，用于制备 前哨淋巴结的多模式成像相同，前哨淋巴结的多模式成像方法也是如此。 本发明的前哨淋巴结标记物在淋巴结处具有较长的保留时间，能够实现多模式成像，因此可以通过近红外线的离体成像来精确检查前哨淋巴结，无需皮肤切口 图像和/或γ射线图像，并且当与用于移除检查的前哨淋巴结的手术结合使用时，可以用肉眼精确地检查前哨淋巴结的位置。

    RADIOISOTOPE LABELED FOLIC ACID CONJUGATE HUMAN SERUM ALBUMIN SPECIFIC TO TUMOR AND SENTINEL LYMPH NODE
    3.
    发明申请
    RADIOISOTOPE LABELED FOLIC ACID CONJUGATE HUMAN SERUM ALBUMIN SPECIFIC TO TUMOR AND SENTINEL LYMPH NODE 审中-公开
    放射性标记的乳酸联合人类血清白蛋白特异于肿瘤和淋巴细胞淋巴细胞

    公开(公告)号：WO2011155805A3

    公开(公告)日：2012-04-26

    申请号：PCT/KR2011004306

    申请日：2011-06-13

    Applicant: NAT CANCER CT ,  KIM SEOK KI ,  KANG SE HUN ,  BAEK NAM SUK ,  KIM YOUNG SANG ,  KIM SEO IL

    Inventor： KIM SEOK KI ,  KANG SE HUN ,  BAEK NAM SUK ,  KIM YOUNG SANG ,  KIM SEO IL

    IPC: G01N33/60 ,  A61K51/08 ,  C07K14/76 ,  G01N33/574

    CPC classification number: C07K14/765 ,  A61K51/0459 ,  A61K51/081

    Abstract: The present invention relates to: radioisotope labeled folic acid conjugate human serum albumin specific to tumor and lymph tissues, and to a preparation method thereof; a disposable kit for images of a tumor and sentinel lymph node which comprises a mixture in which methylene diphosphonic acid, ascorbic acid and stannous chloride are added to folic acid conjugate thiol human serum albumin, and a preparation method of the disposable kit; and a composition for imaging tumor cells metastasized to a sentinel lymph node and comprising radioisotope labeled folic acid conjugate human serum albumin, and an imaging method. According to the present invention, useful effects are derived, of reducing the possibility of a false-negative, and providing a sentinel lymph node marker which further increases the accuracy of biopsies of sentinel lymph nodes because it has characteristics of an active marker specifically binding to a tumor as well as characteristics of a passive marker that remains in a lymph node for a long period of time.

    Abstract translation: 本发明涉及对肿瘤和淋巴组织特异性的放射性同位素标记的叶酸结合人血清白蛋白及其制备方法。 一种用于肿瘤和前哨淋巴结图像的一次性试剂盒，其包含将亚甲基二膦酸，抗坏血酸和氯化亚锡加入到叶酸缀合物硫醇人血清白蛋白中的混合物和一次性试剂盒的制备方法; 以及用于成像转移到前哨淋巴结的肿瘤细胞的组合物，并且包含放射性同位素标记的叶酸结合物人血清白蛋白和成像方法。 根据本发明，导出了有效的效果，降低了假阴性的可能性，并提供了前哨淋巴结标记，其进一步增加了前哨淋巴结活检的准确性，因为它具有特异性结合到 肿瘤以及长时间保留在淋巴结中的被动标记物的特征。

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