公开(公告)号：WO2005001059A2

公开(公告)日：2005-01-06

申请号：PCT/US2004020152

申请日：2004-06-23

Applicant: NOVASTERILIS INC ,  CHRISTENSEN TIM W

Inventor： CHRISTENSEN TIM W

IPC: A61K39/00 ,  A61K39/002 ,  A61K39/02 ,  A61K39/07 ,  A61K39/112 ,  A61K39/12 ,  C12N20060101 ,  C12N7/06 ,  C12Q1/70 ,  C12N

CPC classification number: A61K39/00 ,  A61K39/0275 ,  A61K39/07 ,  A61K2039/521

Abstract: Whole organisms are inactivated by at least a factor of 10 using carbon dioxide at or near its supercritical pressure and temperature conditions.

Abstract translation: 在其超临界压力和温度条件下或其附近，使用二氧化碳将整个生物体灭活至少10 6倍。

公开(公告)号：WO2005001059A3

公开(公告)日：2005-01-06

申请号：PCT/US2004/020152

申请日：2004-06-23

Applicant: NOVASTERILIS INC. ,  CHRISTENSEN, Tim, W.

Inventor： CHRISTENSEN, Tim, W.

IPC: A61K39/002

Abstract: Whole organisms are inactivated by at least a factor of 10 6 using carbon dioxide at or near its supercritical pressure and temperature conditions.

公开(公告)号：WO2005000364B1

公开(公告)日：2005-06-30

申请号：PCT/US2004019242

申请日：2004-06-17

Applicant: NOVASTERILIS INC ,  CHRISTENSEN TIMOTHY WAYNE ,  BURNS DAVID CARROLL ,  WHITE ANGELA LYDIA ,  GANEM BRUCE ,  EISENHUT ANTHONY ROMEY

Inventor： CHRISTENSEN TIMOTHY WAYNE ,  BURNS DAVID CARROLL ,  WHITE ANGELA LYDIA ,  GANEM BRUCE ,  EISENHUT ANTHONY ROMEY

IPC: A61L20060101 ,  A61L2/00 ,  A61L2/18

CPC classification number: A61L2/0094 ,  A61L2/0088 ,  A61L2/186 ,  A61L2/24 ,  A61L2202/24

Abstract: Sterilization methods and apparatus are effective to achieve a 6-log reduction in CFUs of industry standard bacteria and bacterial spores, i.e., B. stearothermophilus and B. subtilis spores, by subjecting sterilizable materials to a chemical additive-containing carbon dioxide sterilant fluid at or near its supercritical pressure and temperature conditions. Most preferably, the chemical additive-containing supercritical carbon dioxide sterilant fluid is agitated during sterilization, e.g.., via mechanical agitation or via pressure cycling.

公开(公告)号：WO2005000364A3

公开(公告)日：2005-01-06

申请号：PCT/US2004/019242

申请日：2004-06-17

Applicant: NOVASTERILIS INC. ,  CHRISTENSEN, Timothy, Wayne ,  BURNS, David, Carroll ,  WHITE, Angela, Lydia ,  GANEM, Bruce ,  EISENHUT, Anthony, Romey

Inventor： CHRISTENSEN, Timothy, Wayne ,  BURNS, David, Carroll ,  WHITE, Angela, Lydia ,  GANEM, Bruce ,  EISENHUT, Anthony, Romey

IPC: A61L2/18

Abstract: Sterilization methods and apparatus are effective to achieve a 6-log reduction in CFUs of industry standard bacteria and bacterial spores, i.e., B. stearothermophilus and B. subtilis spores, by subjecting sterilizable materials to a chemical additive-containing carbon dioxide sterilant fluid at or near its supercritical pressure and temperature conditions. Most preferably, the chemical additive-containing supercritical carbon dioxide sterilant fluid is agitated during sterilization, e.g.., via mechanical agitation or via pressure cycling.

公开(公告)号：WO2005000364A2

公开(公告)日：2005-01-06

申请号：PCT/US2004019242

申请日：2004-06-17

Applicant: NOVASTERILIS INC ,  CHRISTENSEN TIMOTHY WAYNE ,  BURNS DAVID CARROLL ,  WHITE ANGELA LYDIA ,  GANEM BRUCE ,  EISENHUT ANTHONY ROMEY

Inventor： CHRISTENSEN TIMOTHY WAYNE ,  BURNS DAVID CARROLL ,  WHITE ANGELA LYDIA ,  GANEM BRUCE ,  EISENHUT ANTHONY ROMEY

IPC: A61L20060101 ,  A61L2/00 ,  A61L2/18 ,  A61L

CPC classification number: A61L2/0094 ,  A61L2/0088 ,  A61L2/186 ,  A61L2/24 ,  A61L2202/24

Abstract: Sterilization methods and apparatus are effective to achieve a 6-log reduction in CFUs of industry standard bacteria and bacterial spores, i.e., B. stearothermophilus and B. subtilis spores, by subjecting sterilizable materials to a chemical additive-containing carbon dioxide sterilant fluid at or near its supercritical pressure and temperature conditions. Most preferably, the chemical additive-containing supercritical carbon dioxide sterilant fluid is agitated during sterilization, e.g.., via mechanical agitation or via pressure cycling.

Abstract translation: 灭菌方法和设备可有效实现工业标准细菌和细菌孢子（即嗜热脂肪芽孢杆菌和枯草芽孢杆菌孢子）的CFU降低6个对数级，方法是将可消毒材料置于含有化学添加剂的二氧化碳灭菌剂流体或 靠近超临界压力和温度条件。 最优选地，含有化学添加剂的超临界二氧化碳灭菌剂流体在灭菌过程中例如通过机械搅拌或压力循环进行搅拌。