中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

143 records (took 0.03 seconds)

    SUSTAINED RELEASE INACTIVATED VACCINES
    1.
    发明申请
    SUSTAINED RELEASE INACTIVATED VACCINES 审中-公开

    公开(公告)号：WO2022109430A1

    公开(公告)日：2022-05-27

    申请号：PCT/US2021/060407

    申请日：2021-11-22

    Applicant: CASTOR, Trevor, P.

    Inventor： CASTOR, Trevor, Percival

    IPC: A61K39/02 ,  A61K39/12 ,  A61P31/12 ,  A61K9/51 ,  C12N7/06

    Abstract: The present invention is directed to methods and apparatus for creating a sustained release pathogen vaccine for COVID-19, influenza, HIV and other infectious human and animal viruses and pathogens using supercritical, critical, or near-critical fluids with or without polar cosolvents for simultaneously inactivating virions and pathogens, and encapsulating the inactivated virions and pathogens in biodegradable polymer nanospheres for administration to a patient. The present invention continuously inactivates SARS-CoV-2, influenza, HIV and other infectious human and animal viruses and pathogens, and nanoencapsulates the inactivated virions and pathogens in biodegradable polymer nanospheres to provide a safe and effective sustained-release vaccine, especially for the frail and elderly.

    INACTIVATED VACCINE FOR PORCINE EPIDEMIC DIARRHEA VIRUS (PEDV)
    5.
    发明申请
    INACTIVATED VACCINE FOR PORCINE EPIDEMIC DIARRHEA VIRUS (PEDV) 审中-公开
    用于猪流行性腹泻病毒（PEDV）的灭活疫苗

    公开(公告)号：WO2016007955A9

    公开(公告)日：2016-01-14

    申请号：PCT/US2015/040181

    申请日：2015-07-13

    Applicant: MERIAL, INC.

    Inventor： ANBALAGAN, Srivishnupriya ,  COLLIN, Emily ,  HAUSE, Benjamin, Matthew

    IPC: A61K39/225 ,  C07K14/08 ,  C12N7/06

    Abstract: The present invention encompasses porcine epidemic diarrhea virus (PEDV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing inactivated PEDV. The invention also encompasses epitopes or immunogens which can be used to protect porcine animals against PEDV.

    Abstract translation: 本发明包括猪流行性腹泻病毒（PEDV）疫苗或组合物。 疫苗或组合物可以是含有灭活PEDV的疫苗或组合物。 本发明还包括可用于保护猪动物抵抗PEDV的表位或免疫原。

    METHODS, APPARATUSES, AND SYSTEMS FOR CONTINUOUSLY INACTIVATING A VIRUS DURING MANUFACTURE OF A BIOLOGICAL PRODUCT
    6.
    发明申请
    METHODS, APPARATUSES, AND SYSTEMS FOR CONTINUOUSLY INACTIVATING A VIRUS DURING MANUFACTURE OF A BIOLOGICAL PRODUCT 审中-公开
    在生物制品生产过程中持续灭活病毒的方法，装置和系统

    公开(公告)号：WO2015158776A1

    公开(公告)日：2015-10-22

    申请号：PCT/EP2015/058172

    申请日：2015-04-15

    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

    Inventor： COFFMAN, Jonathan ,  GOBY, Jeff ,  GODFREY, Scott ,  OROZCO, Raquel ,  VOGEL, Jens, Holger

    IPC: A61L2/00 ,  C07K1/16 ,  C12N7/04 ,  C12N7/06

    CPC classification number: C12N7/00 ,  A61L2/0082 ,  A61L2202/21 ,  C07K1/14 ,  C07K1/16 ,  C12N2710/00063

    Abstract: Methods for continuously inactivating virus during manufacture of a biological product are provided. The methods include steps of (1) combining (a) a composition including a biological product, and (b) a composition including a virus-inactivation reagent, to obtain (c) a treatment composition having a predetermined property for inactivation of a virus, (2) confirming that the treatment composition exhibits the predetermined property, (3) transferring the treatment composition to a treatment vessel that includes an inlet, an outlet, and a static mixer, the transferring occurring at the inlet, (4) incubating the treatment composition in the treatment vessel at a predetermined temperature while the treatment composition flows at a predetermined rate and contacts the static mixer, and (5) collecting the treatment composition from the treatment vessel at the outlet, wherein steps (1) to (5) are carried out continuously. Apparatuses and systems including such a treatment vessel are also provided.

    Abstract translation: 提供了在制造生物制品期间连续灭活病毒的方法。 所述方法包括以下步骤：（a）包含生物制品的组合物和（b）包含病毒灭活剂的组合物，以获得（c）具有预定的病毒灭活性质的处理组合物， （2）确认处理组合物表现出预定的性能，（3）将处理组合物转移到包括入口，出口和静态混合器的处理容器中，转移发生在入口处，（4）孵育处理 在处理组合物以预定速率流动并接触静态混合器时，处理容器中的预定温度下的组成，和（5）在出口处从处理容器收集处理组合物，其中步骤（1）至（5） 不断进行。 还提供了包括这种处理容器的装置和系统。

    DEVICE FOR PREPARATION AND ANALYSIS OF NUCLEIC ACIDS
    7.
    发明申请
    DEVICE FOR PREPARATION AND ANALYSIS OF NUCLEIC ACIDS 审中-公开
    核酸的制备和分析装置

    公开(公告)号：WO2014182847A1

    公开(公告)日：2014-11-13

    申请号：PCT/US2014/037197

    申请日：2014-05-07

    Applicant: MICRONICS, INC.

    Inventor： LOFQUIST, Alan, K. ,  BATTRELL, C., Frederick ,  BOUZEK, Heather, K.

    IPC: C12Q1/68 ,  C12N7/06 ,  C12N11/14

    CPC classification number: C12N15/1017 ,  B01L3/502753 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/049 ,  C12Q1/6806

    Abstract: An integrated "lab-on-a-chip" microfluidic device performs nucleic acid sample preparation and diagnostic analysis from test samples containing cells and/or particles. The device analyzes DNA or RNA targets, or both, from a common test sample. Dried and/or liquid reagents necessary for nucleic acid sample preparation and analysis are contained on the device, such that the device only requires addition of test sample. Clay mineral and alkaline buffer reagents are employed for overcoming the problems of nucleic acid degradation and contamination during sample preparation. The device may include a composite filter to separate plasma or serum from other blood constituents when the test sample is a blood product. The microfluidic device utilizes a plurality of microfluidic channels, inlets, valves, membranes, pumps, and other elements arranged in various configurations to manipulate the flow of the liquid sample, in particular, in order to prepare nucleic acids and perform further diagnostic analysis.

    Abstract translation: 集成的“芯片上实验室”微流体装置从含有细胞和/或颗粒的测试样品进行核酸样品制备和诊断分析。 该设备从普通测试样品中分析DNA或RNA靶标或两者。 在设备上含有用于核酸样品制备和分析所需的干燥和/或液体试剂，使得该装置仅需要添加测试样品。 粘土矿物和碱性缓冲剂用于克服样品制备过程中核酸降解和污染的问题。 当测试样品是血液制品时，该装置可以包括复合过滤器以将血浆或血清与其它血液成分分离。 微流体装置利用多个微流体通道，入口，阀，膜，泵和以各种构型布置的其它元件，以操纵液体样品的流动，特别是为了制备核酸并进行进一步的诊断分析。

Patent Agency Ranking