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公开(公告)号：WO2014176235A2
公开(公告)日：2014-10-30
申请号：PCT/US2014034948
申请日：2014-04-22
Applicant: ENZO BIOCHEM INC , NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
Inventor： NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
CPC classification number: A61K35/17 , C12N5/0636 , C12N2501/998 , G01N33/505
Abstract: The disclosure relates to methods of identifying a compound that comprises an epitope that induces immune tolerance in a patient suffering from an autoimmune disease. The disclosure further relates to methods of treating an autoimmune disease by administering (i) a compound identified by the methods described herein, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and a compound identified by the methods described herein. The disclosure further relates to methods of treating age-related macular degeneration and uveitis.
Abstract translation: 本公开涉及鉴定包含在患有自身免疫疾病的患者中诱导免疫耐受的表位的化合物的方法。 本公开还涉及通过施用（i）通过本文所述的方法鉴定的化合物，（ii）来自患者或相容供体的调节性T细胞，或（iii）调节性T细胞的组合来治疗自身免疫性疾病的方法， 细胞和通过本文所述方法鉴定的化合物。 本发明还涉及治疗年龄相关性黄斑变性和葡萄膜炎的方法。
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公开(公告)号：WO2014176555A2
公开(公告)日：2014-10-30
申请号：PCT/US2014035549
申请日：2014-04-25
Applicant: ENZO BIOCHEM INC , NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
Inventor： NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
CPC classification number: A61K35/17 , C12N5/0636 , C12N2501/998 , G01N33/505
Abstract: The disclosure relates to methods of identifying a compound that comprises an epitope that induces immune tolerance in a patient suffering from an autoimmune disease. The disclosure further relates to methods of treating an autoimmune disease by administering (i) a compound identified by the methods described herein, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and a compound identified by the methods described herein. The disclosure further relates to methods of treating age- related macular degeneration and uveitis. The disclosure also relates to methods of monitoring, diagnosing and/or prognosticating an autoimmune disease in a patient.
Abstract translation: 本公开涉及鉴定包含在患有自身免疫性疾病的患者中诱导免疫耐受性的表位的化合物的方法。 本公开还涉及通过施用（i）通过本文所述方法鉴定的化合物，（ii）来自患者或相容供体的调节性T细胞，或（iii）调节性T细胞的组合来治疗自身免疫性疾病的方法， 细胞和通过本文所述方法鉴定的化合物。 本公开还涉及治疗年龄相关性黄斑变性和葡萄膜炎的方法。 本公开还涉及监测，诊断和/或预测患者中的自身免疫疾病的方法。
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公开(公告)号：WO2014176555A3
公开(公告)日：2014-10-30
申请号：PCT/US2014/035549
申请日：2014-04-25
Applicant: ENZO BIOCHEM, INC. , NUSSENBLATT, Richard , LIU, Baoying , WEI, Lai , RABBANI, Elazar , DONEGAN, James, J.
Inventor： NUSSENBLATT, Richard , LIU, Baoying , WEI, Lai , RABBANI, Elazar , DONEGAN, James, J.
Abstract: The disclosure relates to methods of identifying a compound that comprises an epitope that induces immune tolerance in a patient suffering from an autoimmune disease. The disclosure further relates to methods of treating an autoimmune disease by administering (i) a compound identified by the methods described herein, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and a compound identified by the methods described herein. The disclosure further relates to methods of treating age- related macular degeneration and uveitis. The disclosure also relates to methods of monitoring, diagnosing and/or prognosticating an autoimmune disease in a patient.
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公开(公告)号：WO2014176235A3
公开(公告)日：2014-10-30
申请号：PCT/US2014/034948
申请日：2014-04-22
Applicant: ENZO BIOCHEM, INC. , NUSSENBLATT, Richard , LIU, Baoying , WEI, Lai , RABBANI, Elazar , DONEGAN, James, J.
Inventor： NUSSENBLATT, Richard , LIU, Baoying , WEI, Lai , RABBANI, Elazar , DONEGAN, James, J.
Abstract: The disclosure relates to methods of identifying a compound that comprises an epitope that induces immune tolerance in a patient suffering from an autoimmune disease. The disclosure further relates to methods of treating an autoimmune disease by administering (i) a compound identified by the methods described herein, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and a compound identified by the methods described herein. The disclosure further relates to methods of treating age-related macular degeneration and uveitis.
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