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公开(公告)号：WO2021188326A1
公开(公告)日：2021-09-23
申请号：PCT/US2021/021609
申请日：2021-03-10
Applicant: ENZO BIOCHEM, INC. , RABBANI, Elazar
Inventor： RABBANI, Elazar
IPC: A61K31/137
Abstract: The invention provides methods and compositions for treating a coronavirus infection using sphingosine kinase- 1 inhibitors, such as SKI -I, and selective sphingosine- 1 -phosphate receptor agonists, such as ozanimod.
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公开(公告)号：WO2020027890A1
公开(公告)日：2020-02-06
申请号：PCT/US2019/029036
申请日：2019-04-25
Applicant: ENZO BIOCHEM, INC. , RABBANI, Elazar , COLEMAN, Jack , MAURO, Maurizio , DONEGAN, James, J.
Inventor： RABBANI, Elazar , COLEMAN, Jack , MAURO, Maurizio , DONEGAN, James, J.
Abstract: The invention provides nucleic acid hybridization probes having improved detectability that include a plurality of first segments consecutively complementary to a target nucleic acid sequence and, between neighboring first segments, a nucleic acid spacer segment which is not complementary to the target nucleic acid sequence and which may include labeled nucleic acid residues. Also provided by the invention are methods for making the probes, methods for using the probes, and compositions of matter that include the probes hybridized to target nucleic acid molecules.
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公开(公告)号：WO2014176555A2
公开(公告)日：2014-10-30
申请号：PCT/US2014035549
申请日：2014-04-25
Applicant: ENZO BIOCHEM INC , NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
Inventor： NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
CPC classification number: A61K35/17 , C12N5/0636 , C12N2501/998 , G01N33/505
Abstract: The disclosure relates to methods of identifying a compound that comprises an epitope that induces immune tolerance in a patient suffering from an autoimmune disease. The disclosure further relates to methods of treating an autoimmune disease by administering (i) a compound identified by the methods described herein, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and a compound identified by the methods described herein. The disclosure further relates to methods of treating age- related macular degeneration and uveitis. The disclosure also relates to methods of monitoring, diagnosing and/or prognosticating an autoimmune disease in a patient.
Abstract translation: 本公开涉及鉴定包含在患有自身免疫性疾病的患者中诱导免疫耐受性的表位的化合物的方法。 本公开还涉及通过施用（i）通过本文所述方法鉴定的化合物，（ii）来自患者或相容供体的调节性T细胞，或（iii）调节性T细胞的组合来治疗自身免疫性疾病的方法， 细胞和通过本文所述方法鉴定的化合物。 本公开还涉及治疗年龄相关性黄斑变性和葡萄膜炎的方法。 本公开还涉及监测，诊断和/或预测患者中的自身免疫疾病的方法。
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公开(公告)号：WO2009086125A3
公开(公告)日：2009-07-09
申请号：PCT/US2008/087713
申请日：2008-12-19
Applicant: ENZO BIOCHEM, INC. , RABBANI, Elazar , STAVRIANOPOULOS, Jannis, G. , DONEGAN, James, J. , PATTON, Wayne , CARCAMO, Juan
Inventor： RABBANI, Elazar , STAVRIANOPOULOS, Jannis, G. , DONEGAN, James, J. , PATTON, Wayne , CARCAMO, Juan
Abstract: The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides. Compositions include nucleic acid compositions and protein compositions with affinity binding pairs, including metal binding peptides and immobilized metals, or peptide affinity groups.
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5.发明申请
公开(公告)号：WO2023278528A1
公开(公告)日：2023-01-05
申请号：PCT/US2022/035455
申请日：2022-06-29
Applicant: ENZO BIOCHEM, INC. , RABBANI, Elazar , COLEMAN, Jack , MAURO, Maurizio
Inventor： RABBANI, Elazar , COLEMAN, Jack , MAURO, Maurizio
Abstract: The invention provides the use of nucleic acid hybridization probes having improved detectability that include a plurality of first segments consecutively complementary to a target nucleic acid sequence and, between neighboring first segments, a nucleic acid spacer segment which is not complementary to the target nucleic acid sequence and which may include labeled nucleic acid residues for the delineation and quantification of DNA methylation in selected regions of chromosomal DNA in conjunction with a method of detecting methylated DNA.
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Patent Agency Ranking6.发明申请COMPREHENSIVE AND COMPARATIVE FLOW CYTOMETRY-BASED METHODS FOR IDENTIFYING THE STATE OF A BIOLOGICAL SYSTEM 审中-公开用于识别生物系统状态的综合和比较流式细胞仪检测方法
公开(公告)号：WO2016105605A1
公开(公告)日：2016-06-30
申请号：PCT/US2015/046912
申请日：2015-08-26
Applicant: ENZO BIOCHEM, INC. , RABBANI, Elazar , DONEGAN, James, J. , L'HULLIER, Andrew, Stewart
Inventor： RABBANI, Elazar , DONEGAN, James, J. , L'HULLIER, Andrew, Stewart
CPC classification number: C12Q1/6886 , C12Q1/6841 , C12Q1/708 , G01N33/505 , C12Q2525/301 , C12Q2545/101 , C12Q2545/113 , C12Q2565/101 , C12Q2565/1015 , C12Q2565/107 , C12Q2565/626
Abstract: The present disclosure provides comprehensive and comparative flow cytometry-based methods for identifying the state of a biological system by identifying the phenotype of cells and correlating the phenotype with the gene expression profile of the cells, which is indicative of cell function. The cells can be immune cells from a subject suffering from immune -mediated disorders that result in imbalance of the immune system and impair a subject's ability to recognize self-antigens or fight infection or disease. In certain aspects, cell phenotype is identified by detecting and/or quantifying one or more markers on the cell surface or intracellularly, which readily enables identification of specific sub-types of cells of interest, which can then be analyzed for gene expression in order to assay cell function. In additional aspects, function of particular subsets of cells identified by cell surface markers is determined by detecting patterns of gene expression, expression of RNA or other markers, by detecting and/or quantifying transcription in the cell, by assaying DNA content, by assaying cell receptors, and/or by detecting the number and/or state of cellular organelles, receptors and/or transport systems.
Abstract translation: 本公开提供了通过鉴定细胞表型并将表型与细胞的基因表达谱相关联来鉴定生物系统的状态的综合和比较的流式细胞术方法，其指示细胞功能。 细胞可以是来自患有免疫介导的障碍的受试者的免疫细胞，其导致免疫系统的不平衡并且损害受试者识别自身抗原或抵抗感染或疾病的能力。 在某些方面，通过检测和/或定量细胞表面或细胞内的一种或多种标志物来鉴定细胞表型，其可以容易地鉴定感兴趣的细胞的特定亚型，然后可以分析它们的基因表达，以便 测定细胞功能。 在另外的方面，通过检测基因表达，RNA或其他标志物的表达，通过检测和/或定量细胞中的转录，通过测定细胞DNA来测定DNA含量来确定特定细胞表面标记子集的功能 和/或通过检测细胞器细胞器，受体和/或转运系统的数量和/或状态。
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公开(公告)号：WO2014176235A2
公开(公告)日：2014-10-30
申请号：PCT/US2014034948
申请日：2014-04-22
Applicant: ENZO BIOCHEM INC , NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
Inventor： NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
CPC classification number: A61K35/17 , C12N5/0636 , C12N2501/998 , G01N33/505
Abstract: The disclosure relates to methods of identifying a compound that comprises an epitope that induces immune tolerance in a patient suffering from an autoimmune disease. The disclosure further relates to methods of treating an autoimmune disease by administering (i) a compound identified by the methods described herein, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and a compound identified by the methods described herein. The disclosure further relates to methods of treating age-related macular degeneration and uveitis.
Abstract translation: 本公开涉及鉴定包含在患有自身免疫疾病的患者中诱导免疫耐受的表位的化合物的方法。 本公开还涉及通过施用（i）通过本文所述的方法鉴定的化合物，（ii）来自患者或相容供体的调节性T细胞，或（iii）调节性T细胞的组合来治疗自身免疫性疾病的方法， 细胞和通过本文所述方法鉴定的化合物。 本发明还涉及治疗年龄相关性黄斑变性和葡萄膜炎的方法。
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公开(公告)号：WO2010028349A3
公开(公告)日：2010-03-11
申请号：PCT/US2009/056198
申请日：2009-09-08
Applicant: ENZO LIFE SCIENCES, INC. , PATTON, Wayne, Forrest , PANDE, Praveen , XIANG, Yuejun , LI, Zaiguo , DONEGAN, James, J. , RABBANI, Elazar
Inventor： PATTON, Wayne, Forrest , PANDE, Praveen , XIANG, Yuejun , LI, Zaiguo , DONEGAN, James, J. , RABBANI, Elazar
Abstract: Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.
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公开(公告)号：WO2014176555A3
公开(公告)日：2014-10-30
申请号：PCT/US2014/035549
申请日：2014-04-25
Applicant: ENZO BIOCHEM, INC. , NUSSENBLATT, Richard , LIU, Baoying , WEI, Lai , RABBANI, Elazar , DONEGAN, James, J.
Inventor： NUSSENBLATT, Richard , LIU, Baoying , WEI, Lai , RABBANI, Elazar , DONEGAN, James, J.
Abstract: The disclosure relates to methods of identifying a compound that comprises an epitope that induces immune tolerance in a patient suffering from an autoimmune disease. The disclosure further relates to methods of treating an autoimmune disease by administering (i) a compound identified by the methods described herein, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and a compound identified by the methods described herein. The disclosure further relates to methods of treating age- related macular degeneration and uveitis. The disclosure also relates to methods of monitoring, diagnosing and/or prognosticating an autoimmune disease in a patient.
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公开(公告)号：WO2014176235A3
公开(公告)日：2014-10-30
申请号：PCT/US2014/034948
申请日：2014-04-22
Applicant: ENZO BIOCHEM, INC. , NUSSENBLATT, Richard , LIU, Baoying , WEI, Lai , RABBANI, Elazar , DONEGAN, James, J.
Inventor： NUSSENBLATT, Richard , LIU, Baoying , WEI, Lai , RABBANI, Elazar , DONEGAN, James, J.
Abstract: The disclosure relates to methods of identifying a compound that comprises an epitope that induces immune tolerance in a patient suffering from an autoimmune disease. The disclosure further relates to methods of treating an autoimmune disease by administering (i) a compound identified by the methods described herein, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and a compound identified by the methods described herein. The disclosure further relates to methods of treating age-related macular degeneration and uveitis.
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