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公开(公告)号：WO2004071529A2
公开(公告)日：2004-08-26
申请号：PCT/IB2004/000366
申请日：2004-02-03
Applicant: PFIZER PRODUCTS INC. , COHEN, Bruce, David , BEDIAN, Vahe , WANG, Huifen, Faye , OBROCEA, Mihail , GOMEZ-NAVARRO, Jesus , CUSMANO, John, Daniel , GUYOT, Deborah, Jean , PAGE, Kelly, Lynn
Inventor： COHEN, Bruce, David , BEDIAN, Vahe , WANG, Huifen, Faye , OBROCEA, Mihail , GOMEZ-NAVARRO, Jesus , CUSMANO, John, Daniel , GUYOT, Deborah, Jean , PAGE, Kelly, Lynn
IPC: A61K39/395
CPC classification number: C07K16/2863 , A61K39/39541 , A61K2039/505 , C07K16/2896 , C07K2317/21 , C07K2317/56 , Y02P20/582 , A61K2300/00
Abstract: The present invention relates to a therapeutic method comprising administering antiIGF-IR antibodies, particularly human anti-IGF-IR antibodies to a subject for the treatment of certain disorders preferably in conjunction with administration of another therapeutic agent. The invention further relates to pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment.
Abstract translation: 本发明涉及一种治疗方法，其包括对受试者施用抗-IGF-IR抗体，特别是人抗IGF-1R抗体，用于治疗某些病症，优选与其它治疗剂的施用相结合。 本发明还涉及包含这些抗体的药物组合物和使用抗体及其组合物进行治疗的方法。
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公开(公告)号：WO2011050344A2
公开(公告)日：2011-04-28
申请号：PCT/US2010053879
申请日：2010-10-22
Applicant: MANNKIND CORP , BOT ADRIAN ION , QIU ZHIYONG , DIAMOND DAVID C , OBROCEA MIHAIL
Inventor： BOT ADRIAN ION , QIU ZHIYONG , DIAMOND DAVID C , OBROCEA MIHAIL
IPC: A61K39/00
CPC classification number: A61K39/0011 , A61K2039/53 , A61K2039/545
Abstract: The instant disclosure relates to methods for treating a cancer patient with an active immunotherapeutic, wherein the methods include assessing a patient's pre-existing immunoreactivity to at least one target antigen, choosing an immunotherapeutic regimen based on the level of pre-existing immunoreactivity, and administering an active immunotherapeutic according to the regimen.
Abstract translation: 本公开涉及用活性免疫治疗剂治疗癌症患者的方法，其中所述方法包括评估患者对至少一种靶抗原的预先存在的免疫反应性，基于预先存在的免疫反应性水平选择免疫治疗方案， 根据该方案的活性免疫治疗剂。
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公开(公告)号：WO2011050344A3
公开(公告)日：2011-04-28
申请号：PCT/US2010/053879
申请日：2010-10-22
Applicant: MANNKIND CORPORATION , BOT, Adrian, Ion , QIU, Zhiyong , DIAMOND, David, C. , OBROCEA, Mihail
Inventor： BOT, Adrian, Ion , QIU, Zhiyong , DIAMOND, David, C. , OBROCEA, Mihail
Abstract: The instant disclosure relates to methods for treating a cancer patient with an active immunotherapeutic, wherein the methods include assessing a patient's pre-existing immunoreactivity to at least one target antigen, choosing an immunotherapeutic regimen based on the level of pre-existing immunoreactivity, and administering an active immunotherapeutic according to the regimen.
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公开(公告)号：WO2004071529A3
公开(公告)日：2005-05-06
申请号：PCT/IB2004000366
申请日：2004-02-03
Applicant: PFIZER PROD INC , COHEN BRUCE DAVID , BEDIAN VAHE , WANG HUIFEN FAYE , OBROCEA MIHAIL , GOMEZ-NAVARRO JESUS , CUSMANO JOHN DANIEL , GUYOT DEBORAH JEAN , PAGE KELLY LYNN
Inventor： COHEN BRUCE DAVID , BEDIAN VAHE , WANG HUIFEN FAYE , OBROCEA MIHAIL , GOMEZ-NAVARRO JESUS , CUSMANO JOHN DANIEL , GUYOT DEBORAH JEAN , PAGE KELLY LYNN
CPC classification number: C07K16/2863 , A61K39/39541 , A61K2039/505 , C07K16/2896 , C07K2317/21 , C07K2317/56 , Y02P20/582 , A61K2300/00
Abstract: The present invention relates to a therapeutic method comprising administering antiIGF-IR antibodies, particularly human anti-IGF-IR antibodies to a subject for the treatment of certain disorders preferably in conjunction with administration of another therapeutic agent. The invention further relates to pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment.
Abstract translation: 本发明涉及一种治疗方法，其包括对受试者施用抗-IGF-IR抗体，特别是人抗IGF-1R抗体，用于治疗某些病症，优选与其它治疗剂的施用相结合。 本发明还涉及包含这些抗体的药物组合物和使用抗体及其组合物进行治疗的方法。
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