公开(公告)号：WO2004020431A3

公开(公告)日：2004-05-13

申请号：PCT/IB0303634

申请日：2003-08-14

Applicant: PFIZER PROD INC ,  KATH JOHN CHARLES ,  LYSSIKATOS JOSEPH PETER ,  WANG HUIFEN FAYE

Inventor： KATH JOHN CHARLES ,  LYSSIKATOS JOSEPH PETER ,  WANG HUIFEN FAYE

IPC: A61K31/4709 ,  A61P35/00 ,  C07D401/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D401/04 ,  A61K31/415

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D405/14

Abstract: The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R , R , R , and R are as defined herein. The invention also relates to methods of treating abnormal cell growth, such as cancer, in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.

Abstract translation: 本发明涉及式1的化合物及其药学上可接受的盐，前药和溶剂合物，其中R 1，R 2，R 3和R 4如本文所定义。 本发明还涉及通过施用式1化合物治疗哺乳动物异常细胞生长如癌症的方法，并涉及用于治疗含有式1化合物的这类疾病的药物组合物。本发明还涉及制备 式1的化合物。

公开(公告)号：WO2004071529A2

公开(公告)日：2004-08-26

申请号：PCT/IB2004/000366

申请日：2004-02-03

Applicant: PFIZER PRODUCTS INC. ,  COHEN, Bruce, David ,  BEDIAN, Vahe ,  WANG, Huifen, Faye ,  OBROCEA, Mihail ,  GOMEZ-NAVARRO, Jesus ,  CUSMANO, John, Daniel ,  GUYOT, Deborah, Jean ,  PAGE, Kelly, Lynn

Inventor： COHEN, Bruce, David ,  BEDIAN, Vahe ,  WANG, Huifen, Faye ,  OBROCEA, Mihail ,  GOMEZ-NAVARRO, Jesus ,  CUSMANO, John, Daniel ,  GUYOT, Deborah, Jean ,  PAGE, Kelly, Lynn

IPC: A61K39/395

CPC classification number: C07K16/2863 ,  A61K39/39541 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/21 ,  C07K2317/56 ,  Y02P20/582 ,  A61K2300/00

Abstract: The present invention relates to a therapeutic method comprising administering anti­IGF-IR antibodies, particularly human anti-IGF-IR antibodies to a subject for the treatment of certain disorders preferably in conjunction with administration of another therapeutic agent. The invention further relates to pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment.

Abstract translation: 本发明涉及一种治疗方法，其包括对受试者施用抗-IGF-IR抗体，特别是人抗IGF-1R抗体，用于治疗某些病症，优选与其它治疗剂的施用相结合。 本发明还涉及包含这些抗体的药物组合物和使用抗体及其组合物进行治疗的方法。

公开(公告)号：WO2004071529A3

公开(公告)日：2005-05-06

申请号：PCT/IB2004000366

申请日：2004-02-03

Applicant: PFIZER PROD INC ,  COHEN BRUCE DAVID ,  BEDIAN VAHE ,  WANG HUIFEN FAYE ,  OBROCEA MIHAIL ,  GOMEZ-NAVARRO JESUS ,  CUSMANO JOHN DANIEL ,  GUYOT DEBORAH JEAN ,  PAGE KELLY LYNN

Inventor： COHEN BRUCE DAVID ,  BEDIAN VAHE ,  WANG HUIFEN FAYE ,  OBROCEA MIHAIL ,  GOMEZ-NAVARRO JESUS ,  CUSMANO JOHN DANIEL ,  GUYOT DEBORAH JEAN ,  PAGE KELLY LYNN

IPC: A61K39/395 ,  A61P5/00 ,  A61P9/10 ,  A61P25/28 ,  A61P35/00 ,  A61P37/00 ,  C07K16/28

CPC classification number: C07K16/2863 ,  A61K39/39541 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/21 ,  C07K2317/56 ,  Y02P20/582 ,  A61K2300/00

Abstract: The present invention relates to a therapeutic method comprising administering anti­IGF-IR antibodies, particularly human anti-IGF-IR antibodies to a subject for the treatment of certain disorders preferably in conjunction with administration of another therapeutic agent. The invention further relates to pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment.

Abstract translation: 本发明涉及一种治疗方法，其包括对受试者施用抗-IGF-IR抗体，特别是人抗IGF-1R抗体，用于治疗某些病症，优选与其它治疗剂的施用相结合。 本发明还涉及包含这些抗体的药物组合物和使用抗体及其组合物进行治疗的方法。

公开(公告)号：WO2004020431A2

公开(公告)日：2004-03-11

申请号：PCT/IB2003/003634

申请日：2003-08-14

Applicant: PFIZER PRODUCTS INC. ,  KATH, John, Charles ,  LYSSIKATOS, Joseph, Peter ,  WANG, Huifen, Faye

Inventor： KATH, John, Charles ,  LYSSIKATOS, Joseph, Peter ,  WANG, Huifen, Faye

IPC: C07D401/00

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D405/14

Abstract: The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R 1 , R 2 , R 3 , and R 4 are as defined herein. The invention also relates to methods of treating abnormal cell growth, such as cancer, in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.

Abstract translation: 本发明涉及式1的化合物及其药学上可接受的盐，前药和溶剂合物，其中R 1，R 2，R 3和R 4如本文所定义。 本发明还涉及通过施用式1的化合物和用于治疗含有式1化合物的这种病症的药物组合物来治疗哺乳动物中的异常细胞生长例如癌症的方法。本发明还涉及制备 式1的化合物。