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    PEG-COATED CORE-SHELL SILICA NANOPARTICLES AND METHODS OF MANUFACTURE AND USE
    3.
    发明申请
    PEG-COATED CORE-SHELL SILICA NANOPARTICLES AND METHODS OF MANUFACTURE AND USE 审中-公开
    PEG涂层核心二氧化硅纳米粒子及其制造和使用方法

    公开(公告)号：WO2009029870A3

    公开(公告)日：2009-05-07

    申请号：PCT/US2008074894

    申请日：2008-08-29

    Applicant: HYBRID SILICA TECHNOLOGIES INC ,  WIESNER ULRICH ,  OW HOOISWENG

    Inventor： WIESNER ULRICH ,  OW HOOISWENG

    IPC: C01B33/12 ,  B32B5/16 ,  B82B1/00 ,  C09K11/02

    CPC classification number: C09K11/025 ,  A61K49/0032 ,  A61K49/0093 ,  C09K11/06

    Abstract: Described herein are PEG-coated, core-shell nanoparticles, which display reduced aggregation and/or reduced non-specific or undesired attachment characteristics. These fluorescent nanoparticle include: a silica-based core having an organic functional group that includes a mercapto substitituent, an organic fluorescent compound, a silica shell; and a silane-PEG compound. The silica shell of the nanoparticle encapsulates the silica-based core and the silane-PEG compound is conjugated to the silica shell.

    Abstract translation: 本文描述的是PEG-包覆的核 - 壳纳米颗粒，其显示减少的聚集和/或降低的非特异性或不期望的附着特征。 这些荧光纳米粒子包括：具有巯基取代基的有机官能团的二氧化硅类核，有机荧光化合物，二氧化硅壳; 和硅烷-PEG化合物。 纳米颗粒的二氧化硅壳包封二氧化硅基核，硅烷-PEG化合物与二氧化硅壳结合。

    FLUORESCENT SILICA-BASED NANOPARTICLES
    5.
    发明申请
    FLUORESCENT SILICA-BASED NANOPARTICLES 审中-公开

    公开(公告)号：WO2004074504A3

    公开(公告)日：2004-09-02

    申请号：PCT/US2003/037963

    申请日：2003-11-26

    Applicant: CORNELL RESEARCH FOUNDATION, INC. ,  WIESNER, Ulrich ,  OW, Hooisweng ,  LARSON, Daniel, E. ,  WEBB, Watt, W.

    Inventor： WIESNER, Ulrich ,  OW, Hooisweng ,  LARSON, Daniel, E. ,  WEBB, Watt, W.

    IPC: B32B5/16

    Abstract: The invention generally relates to fluorescent nanoparticles and more specifically to silica-based fluorescent nanoparticles of less than 30nm with covalently attached organic dyes. The invention provides a fluorescent monodisperse silica nanoparticle comprising fluorophore center core and a silica shell wherein the radiative properties of the nanoparticle are dependent upon the chemistry (composition) of the core and presence of the silica shell. In one aspect of the invention, the core-shell architecture provides an enhancement in fluorescence quantum efficiency. The invention generally provides control of photophysical properties of dye molecules encapsulated within silica particles with sizes down to 30 nm and below. This control is accomplished through changes in silica chemistry and particle architecture on the nanometer size scale and results in significant brightness enhancement compared to free dye.

    FLUORESCENT SILICA-BASED NANOPARTICLES
    6.
    发明申请
    FLUORESCENT SILICA-BASED NANOPARTICLES 审中-公开

    公开(公告)号：WO2004063387A3

    公开(公告)日：2004-07-29

    申请号：PCT/US2003/037793

    申请日：2003-11-26

    Applicant: CORNELL RESEARCH FOUNDATION, INC. ,  WIESNER, Ulrich, B. ,  OW, Hooisweng

    Inventor： WIESNER, Ulrich, B. ,  OW, Hooisweng

    IPC: C12Q1/00

    Abstract: The present invention provides nanoparticle compositions comprising, for example, a core comprising a fluorescent silane compound; and a silica shell on the core. Also provided are methods for the preparation of nanoparticle compositions including fluorescent nanoparticles, ligated-fluorescent nanoparticles, ligated-fluorescent nanoparticles having therapeutic agents, and ligated-fluorescent nanoparticles coupled or associated with an analyte. Also provided are methods: for the detection of the ligated-fluorescent nanoparticles; for associating the linked-fluorescent nanoparticles with a cellular component of interest and recording or monitoring the movement of the cellular component; for improving the therapeutic properties of the therapeutic agent by combining the therapeutic agent with linked-fluorescent nanoparticles and contacting or administering the combination to a cell or organism; for making and using the fluorescent nanoparticles in, for example, diagnostic agents for the detection of various analytes, and like applications.

    PEG-COATED CORE-SHELL SILICA NANOPARTICLES AND METHODS OF MANUFACTURE AND USE
    9.
    发明申请
    PEG-COATED CORE-SHELL SILICA NANOPARTICLES AND METHODS OF MANUFACTURE AND USE 审中-公开
    PEG包覆的核壳型二氧化硅纳米颗粒及其制造和使用方法

    公开(公告)号：WO2009029870A2

    公开(公告)日：2009-03-05

    申请号：PCT/US2008/074894

    申请日：2008-08-29

    Applicant: HYBRID SILICA TECHNOLOGIES, INC. ,  WIESNER, Ulrich ,  OW, Hooisweng

    Inventor： WIESNER, Ulrich ,  OW, Hooisweng

    IPC: C01B33/12 ,  C09K11/02 ,  B82B1/00 ,  B32B5/16

    CPC classification number: C09K11/025 ,  A61K49/0032 ,  A61K49/0093 ,  C09K11/06

    Abstract: Described herein are PEG-coated, core-shell nanoparticles, which display reduced aggregation and/or reduced non-specific or undesired attachment characteristics. These fluorescent nanoparticle include: a silica-based core having an organic functional group that includes a mercapto substitituent, an organic fluorescent compound, a silica shell; and a silane-PEG compound. The silica shell of the nanoparticle encapsulates the silica-based core and the silane-PEG compound is conjugated to the silica shell.

    Abstract translation: 本文描述了PEG-包被的核 - 壳纳米颗粒，其表现出降低的聚集和/或降低的非特异性或不期望的附着特征。 这些荧光纳米粒子包括：具有包含巯基取代基的有机官能团的二氧化硅基核，有机荧光化合物，二氧化硅壳; 和硅烷-PEG化合物。 纳米粒子的二氧化硅壳包封二氧化硅基核，而硅烷-PEG化合物与二氧化硅壳结合。

    FLUORESCENT SILICA-BASED NANOPARTICLES
    10.
    发明申请
    FLUORESCENT SILICA-BASED NANOPARTICLES 审中-公开
    荧光硅基纳米粒子

    公开(公告)号：WO2004074504A2

    公开(公告)日：2004-09-02

    申请号：PCT/US0337963

    申请日：2003-11-26

    Applicant: CORNELL RES FOUNDATION INC ,  WIESNER ULRICH ,  OW HOOISWENG ,  LARSON DANIEL E ,  WEBB WATT W

    Inventor： WIESNER ULRICH ,  OW HOOISWENG ,  LARSON DANIEL E ,  WEBB WATT W

    IPC: G01N33/50 ,  G01N33/58 ,  C12Q

    CPC classification number: C09K11/025 ,  B82Y30/00 ,  C01B33/18 ,  C01P2002/80 ,  C01P2004/03 ,  C01P2004/64 ,  C07K16/00 ,  C07K2317/52 ,  C09K11/06 ,  G01N33/5005 ,  G01N33/54346 ,  G01N33/582 ,  G01N33/587 ,  Y10T428/2438 ,  Y10T428/31663

    Abstract: The invention generally relates to fluorescent nanoparticles and more specifically to silica-based fluorescent nanoparticles of less than 30nm with covalently attached organic dyes. The invention provides a fluorescent monodisperse silica nanoparticle comprising fluorophore center core and a silica shell wherein the radiative properties of the nanoparticle are dependent upon the chemistry (composition) of the core and presence of the silica shell. In one aspect of the invention, the core-shell architecture provides an enhancement in fluorescence quantum efficiency. The invention generally provides control of photophysical properties of dye molecules encapsulated within silica particles with sizes down to 30 nm and below. This control is accomplished through changes in silica chemistry and particle architecture on the nanometer size scale and results in significant brightness enhancement compared to free dye.

    Abstract translation: 本发明总体上涉及荧光纳米颗粒，更具体地涉及具有共价连接的有机染料的小于30nm的基于二氧化硅的荧光纳米颗粒。 本发明提供包含荧光团中心核和二氧化硅壳的荧光单分散二氧化硅纳米粒子，其中纳米粒子的辐射特性取决于核的化学（组成）和二氧化硅壳的存在。 在本发明的一个方面中，核 - 壳结构提供荧光量子效率的增强。 本发明通常提供对包封在二氧化硅颗粒内的染料分子的光物理性质的控制，其尺寸低至30nm及以下。 这种控制是通过改变二氧化硅化学和纳米尺寸的粒子结构来实现的，并且与游离染料相比导致明显的亮度增强。

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