公开(公告)号：WO2007014188A2

公开(公告)日：2007-02-01

申请号：PCT/US2006/028770

申请日：2006-07-25

Applicant: DUKE UNIVERSITY ,  WISCONSIN ALUMNI RESEARCH FOUNDATION ,  PALMER, Gregory, M. ,  RAMANUJAM, Nimala

Inventor： PALMER, Gregory, M. ,  RAMANUJAM, Nimala

IPC: G01N21/47

CPC classification number: G01N21/4738 ,  G01N2021/4742 ,  G01N2021/4752 ,  G01N2201/1296

Abstract: The presently disclosed subject matter provides methods, systems, and computer program products for optimizing a probe geometry for spectroscopic measurement in a turbid medium. According to one method, a probe geometry comprising one emitting entity for emitting electromagnetic radiation into a turbid medium and at least on collecting entity for collecting the electromagnetic radiation that has interacted with the turbid medium is selected. A simulation is performed with inputs of the probe geometry and a plurality of sets of optical property values associated with the turbid medium to generate output comprising optical parameter values measured by the probe geometry for each set of input optical property values. The measured optical parameter values are input to an inversion algorithm to produce corresponding optical properties as output. The produced optical properties are compared with optical properties known to correspond to the measured optical parameter values and a degree of matching between the produced optical properties and the known optical properties is determined. The simulation and inversion steps are repeated for a plurality of additional probe geometries. Each additional probe geometry differs from the previously tested probe geometry in at least one property. The property may be a quantity of collecting entities, a diameter of at least one emitting or collecting entity, a linear between the emitting and collecting entities, or combinations thereof. An optimization algorithm is applied at each iteration to select a probe geometry such that the resulting degree of matching will converge to an optimum value. An optimal geometry is selected based on the degree of matching determined for each geometry.

Abstract translation: 目前公开的主题提供了用于优化用于在混浊介质中进行光谱测量的探针几何形状的方法，系统和计算机程序产品。 根据一种方法，选择包括用于将电磁辐射发射到混浊介质中的至少一个发射实体的探针几何形状，并且至少在用于收集与混浊介质相互作用的电磁辐射的收集体上。 使用探针几何的输入和与浑浊介质相关联的多组光学性质值的输入来执行模拟，以产生包括由每组输入光学性质值由探针几何测量的光学参数值的输出。 测量的光学参数值被输入到反演算法中以产生相应的光学特性作为输出。 将所产生的光学性质与已知对应于测量的光学参数值的光学性质进行比较，并且确定所产生的光学性质和已知的光学性质之间的匹配程度。 对于多个额外的探针几何形状，重复模拟和反转步骤。 每个附加的探针几何与至少一个属性中先前测试的探针几何不同。 该属性可以是一定数量的收集实体，至少一个发射或收集实体的直径，发射和收集实体之间的线性，或其组合。 在每个迭代中应用优化算法来选择探针几何，使得所得到的匹配度将会收敛到最佳值。 基于为每个几何确定的匹配程度来选择最佳几何。

公开(公告)号：WO2007014188A3

公开(公告)日：2009-04-30

申请号：PCT/US2006028770

申请日：2006-07-25

Applicant: UNIV DUKE ,  WISCONSIN ALUMNI RES FOUND ,  PALMER GREGORY M ,  RAMANUJAM NIMALA

Inventor： PALMER GREGORY M ,  RAMANUJAM NIMALA

IPC: G01N21/00

CPC classification number: G01N21/4738 ,  G01N2021/4742 ,  G01N2021/4752 ,  G01N2201/1296

Abstract: The presently disclosed subject matter provides methods, systems, and computer program products for optimizing a probe geometry for spectroscopic measurement in a turbid medium. A probe geometry comprising one emitting entity for emitting electromagnetic radiation into a turbid medium and at least one collecting entity for collecting the electromagnetic radiation that has interacted with the turbid medium is selected. A simulation is performed with inputs of the probe geometry and a plurality of sets of optical property values associated with the turbid medium to generate output comprising optical parameter values measured by the probe geometry for each set of input optical property values. The measured optical parameter values are input to an Inversion algorithm to produce corresponding optical properties as output and are compared to reference values. The simulation and inversion steps are repeated and compared for a plurality of additional probe geometries and an optimal geometry is selected.

Abstract translation: 目前公开的主题提供了用于优化用于在混浊介质中进行光谱测量的探针几何形状的方法，系统和计算机程序产品。 选择包括用于将电磁辐射发射到混浊介质中的一个发射实体的探针几何形状和用于收集与混浊介质相互作用的电磁辐射的至少一个收集实体。 使用探针几何的输入和与浑浊介质相关联的多组光学性质值的输入来执行模拟，以产生包括由每组输入光学性质值由探针几何测量的光学参数值的输出。 测量的光学参数值被输入到反转算法，以产生相应的光学性质作为输出并且与参考值进行比较。 重复模拟和反演步骤并对多个附加探针几何进行比较，并选择最佳几何形状。

公开(公告)号：WO2006071920A2

公开(公告)日：2006-07-06

申请号：PCT/US2005/047194

申请日：2005-12-29

Applicant: HUNTER PAINE ENTERPRISES, LLC ,  ROTH, Arthur, J. ,  PALMER, Gregory, M.

Inventor： ROTH, Arthur, J. ,  PALMER, Gregory, M.

CPC classification number: B65D19/0073 ,  B65D2519/00044 ,  B65D2519/00079 ,  B65D2519/00114 ,  B65D2519/00129 ,  B65D2519/00273 ,  B65D2519/00288 ,  B65D2519/00338 ,  Y10T428/24612 ,  Y10T428/24628 ,  Y10T428/249953 ,  Y10T428/25 ,  Y10T428/252

Abstract: A composite structural material suitable, for example, as a replacement for wooden boards, sheets, or posts, is disclosed. It comprises a dimensionally stable core material substantially surrounded by a dimensionally stable, laminar covering that is adherent to the core material. The laminar covering is comprised of at least one band of substantially parallel reinforcing cords bonded to at least one layer of a dimensionally stable web material selected from the group consisting of rigidified paper and rigidified cloth. Preferably the band of reinforcing cords is sandwiched between two layers of rigidified paper or cloth. The core material can be, for example, a foamed synthetic resin with or without filler. A continuous process for manufacturing the material is disclosed.

Abstract translation: 公开了一种适用于例如木板，板或柱的替代物的复合结构材料。 其包括尺寸稳定的芯材料，其基本上被尺寸稳定的层状覆盖层包围，所述层状覆盖物粘附于芯材料。 层状覆盖层由至少一个基本上平行的加强帘线带组成，粘合到至少一层尺寸稳定的纤维网材料，该纤维网材料选自刚性纸和刚性布。 优选地，加强帘线带被夹在两层硬化纸或布之间。 核心材料可以是例如具有或不具有填料的发泡合成树脂。 公开了用于制造材料的连续工艺。

公开(公告)号：WO2007109126A2

公开(公告)日：2007-09-27

申请号：PCT/US2007/006624

申请日：2007-03-16

Applicant: DUKE UNIVERSITY ,  PALMER, Gregory, M. ,  RAMANUJAM, Nirmala

Inventor： PALMER, Gregory, M. ,  RAMANUJAM, Nirmala

IPC: A61B6/00 ,  G01J3/30

CPC classification number: G01J3/4406 ,  A61B5/0071 ,  A61B5/0084 ,  G01N21/49 ,  G01N21/6486 ,  G01N2021/6417

Abstract: The subject matter described herein includes a method for modeling fluorescence in turbid media and methods and systems for using the model to determine intrinsic fluorescence of turbid media. According to one aspect, a method for modeling fluorescence of a turbid medium and for using the model to determine intrinsic fluorescence in the turbid medium is provided. The method includes illuminating a turbid medium of interest with an electromagnetic radiation source using a probe of a particular geometry and detecting measured fluorescence for the turbid medium using the probe. At least one set of Monte Carlo simulations is run to determine an escape energy probability map and an absorbed energy density map for the turbid medium. An indication of the intrinsic fluorescence of the turbid medium is determined using the escape probability density map and the absorbed energy density map in a manner that accounts for the geometry of the probe.

Abstract translation: 本文描述的主题包括用于对混浊介质中的荧光进行建模的方法以及使用该模型确定混浊介质的固有荧光的方法和系统。 根据一个方面，提供了一种用于对浑浊介质的荧光进行建模和使用该模型来确定混浊介质中的固有荧光的方法。 该方法包括使用特定几何形状的探针用电磁辐射源照射感兴趣的混浊介质，并使用探针检测浊度介质的测量荧光。 运行至少一组蒙特卡罗模拟来确定浑浊介质的逃逸能量概率图和吸收的能量密度图。 使用逃避概率密度图和吸收的能量密度图以考虑探针的几何形状的方式确定混浊介质的固有荧光的指示。

公开(公告)号：WO2006071920A3

公开(公告)日：2009-04-16

申请号：PCT/US2005047194

申请日：2005-12-29

Applicant: HUNTER PAINE ENTPR LLC ,  ROTH ARTHUR J ,  PALMER GREGORY M

Inventor： ROTH ARTHUR J ,  PALMER GREGORY M

IPC: A47B91/00

CPC classification number: B65D19/0073 ,  B65D2519/00044 ,  B65D2519/00079 ,  B65D2519/00114 ,  B65D2519/00129 ,  B65D2519/00273 ,  B65D2519/00288 ,  B65D2519/00338 ,  Y10T428/24612 ,  Y10T428/24628 ,  Y10T428/249953 ,  Y10T428/25 ,  Y10T428/252

Abstract: A composite structural material suitable, for example, as a replacement for wooden boards, sheets, or posts, is disclosed. It comprises a dimensionally stable core material substantially surrounded by a dimensionally stable, laminar covering that is adherent to the core material. The laminar covering is comprised of at least one band of substantially parallel reinforcing cords bonded to at least one layer of a dimensionally stable web material selected from the group consisting of rigidified paper and rigidified cloth. Preferably the band of reinforcing cords is sandwiched between two layers of rigidified paper or cloth. The core material can be, for example, a foamed synthetic resin with or without filler. A continuous process for manufacturing the material is disclosed.

Abstract translation: 公开了一种适用于例如木板，板或柱的替代物的复合结构材料。 其包括尺寸稳定的芯材料，其基本上被尺寸稳定的层状覆盖层包围，所述层状覆盖物粘附于芯材料。 层状覆盖层由至少一个基本上平行的加强帘线带组成，粘合到至少一层尺寸稳定的纤维网材料，该纤维网材料选自刚性纸和刚性布。 优选地，加强帘线带被夹在两层硬化纸或布之间。 核心材料可以是例如具有或不具有填料的发泡合成树脂。 公开了用于制造材料的连续工艺。

公开(公告)号：WO2007109126A3

公开(公告)日：2008-03-27

申请号：PCT/US2007006624

申请日：2007-03-16

Applicant: UNIV DUKE ,  PALMER GREGORY M ,  RAMANUJAM NIRMALA

Inventor： PALMER GREGORY M ,  RAMANUJAM NIRMALA

IPC: A61B5/00 ,  F21V9/16 ,  G01T1/10

CPC classification number: G01J3/4406 ,  A61B5/0071 ,  A61B5/0084 ,  G01N21/49 ,  G01N21/6486 ,  G01N2021/6417

Abstract: The subject matter described herein includes a method for modeling fluorescence in turbid media and methods and systems for using the model to determine intrinsic fluorescence of turbid media. According to one aspect, a method for modeling fluorescence of a turbid medium and for using the model to determine intrinsic fluorescence in the turbid medium is provided. The method includes illuminating a turbid medium of interest with an electromagnetic radiation source using a probe of a particular geometry and detecting measured fluorescence for the turbid medium using the probe. At least one set of Monte Carlo simulations is run to determine an escape energy probability map and an absorbed energy density map for the turbid medium. An indication of the intrinsic fluorescence of the turbid medium is determined using the escape probability density map and the absorbed energy density map in a manner that accounts for the geometry of the probe.

Abstract translation: 本文描述的主题包括用于对混浊介质中的荧光进行建模的方法以及使用该模型确定混浊介质的固有荧光的方法和系统。 根据一个方面，提供了一种用于对浑浊介质的荧光进行建模和使用该模型来确定混浊介质中的固有荧光的方法。 该方法包括使用特定几何形状的探针用电磁辐射源照射感兴趣的混浊介质，并使用探针检测浊度介质的测量荧光。 运行至少一组蒙特卡罗模拟来确定浑浊介质的逃逸能量概率图和吸收的能量密度图。 使用逃避概率密度图和吸收的能量密度图以考虑探针的几何形状的方式确定混浊介质的固有荧光的指示。