公开(公告)号：WO2005023224A1

公开(公告)日：2005-03-17

申请号：PCT/KR2004/002241

申请日：2004-09-03

Applicant: PEPTRON CO., LTD ,  LEE, Hee Yong ,  JUNG, Young Hwan ,  KIM, Jung In ,  KIM, Sung Kyu ,  KIM, Jung Soo ,  CHANG, Seung Gu ,  PARK, Kee Don ,  CHOI, Ho Il

Inventor： LEE, Hee Yong ,  JUNG, Young Hwan ,  KIM, Jung In ,  KIM, Sung Kyu ,  KIM, Jung Soo ,  CHANG, Seung Gu ,  PARK, Kee Don ,  CHOI, Ho Il

IPC: A61K9/16

CPC classification number: A61K9/1647 ,  A61K9/1682 ,  A61K9/1694 ,  A61K38/09

Abstract: Disclosed is a method of preparing sustained release microspheres by spray-drying liquids with different compositions for preparation the sustained release microspheres through an ultrasonic dual-feed nozzle. Unlike conventional methods of preparing sustained release microspheres by spray-drying a single liquid containing a biodegradable polymer, a drug, an additive and a solvent through a single-feed nozzle, the present method is characterized by simultaneously spray-drying two liquids with different compositions for preparation of the sustained release microspheres respectively through internal and external channels of an ultrasonic dual-feed nozzle to coat sprayed droplets through the internal channel with other sprayed droplets through the external channel. The present method is effective in achieving a low initial release and a desired continuous release.

Abstract translation: 公开了一种通过喷雾干燥具有不同组成的液体制备缓释微球的方法，用于通过超声波双重给料喷嘴制备缓释微球。 与通过单一进料喷嘴喷雾干燥含有可生物降解的聚合物，药物，添加剂和溶剂的单一液体制备缓释微球体的常规方法不同，本方法的特征在于同时喷雾干燥具有不同组成的两种液体 分别通过超声双馈喷嘴的内部和外部通道制备缓释微球，通过内部通道将喷雾的液滴通过外部通道与其他喷雾液滴一起涂覆。 本发明的方法在实现低的初始释放和期望的连续释放方面是有效的。

公开(公告)号：WO2004112752A1

公开(公告)日：2004-12-29

申请号：PCT/KR2004/001558

申请日：2004-06-25

Applicant: PEPTRON CO., LTD ,  LEE, Hee Yong ,  KIM, Sung Kyu ,  KIM, Jung Soo ,  LEE, Ji Suk ,  JUNG, Young Hwan ,  KIM, Jung In ,  SEO, Yun Mi ,  CHANG, Seung Gu ,  PARK, Kee Don ,  CHOI, Ho Il

Inventor： LEE, Hee Yong ,  KIM, Sung Kyu ,  KIM, Jung Soo ,  LEE, Ji Suk ,  JUNG, Young Hwan ,  KIM, Jung In ,  SEO, Yun Mi ,  CHANG, Seung Gu ,  PARK, Kee Don ,  CHOI, Ho Il

IPC: A61K9/16

CPC classification number: A61K9/1694 ,  A61K9/1647 ,  A61K9/5084 ,  A61K38/24

Abstract: Disclosed is a method for preparing a mixed formulation of sustained release microspheres with various compositions by a continuous one-step process. The present method is characterized by preparing the mixed formulation of sustained release microspheres with different compositions by a continuous one-step process by continuously introducing the mixed fluids into a dryer from the two or more different fluids for preparation of sustained release microspheres containing a biodegradable polymer, a drug, an additive and a solvent with different types of contents or both of the components, by controlling the mixing ratios of the fluids according to the time, unlike a conventional method including spray-drying a mixture of microspheres containing a biodegradable polymer, a drug, an additive and a solvent with a single composition. The present method can achieve a desired drug release, which is difficult to be obtained by conventional microspheres with a single composition, by preparing microspheres by a continuous one-step process, and can simplify the conventional complex process of separately preparing several microsphere formulations and then mixing the formulations at a proper ratio to achieve a desired drug release.

Abstract translation: 公开了通过连续一步法制备具有各种组成的缓释微球混合制剂的方法。 本发明的方法的特征在于通过连续一步法制备具有不同组成的缓释微球的混合制剂，通过从两种或更多种不同的流体连续引入混合流体到干燥器中，用于制备含有可生物降解聚合物的缓释微球 ，药物，添加剂和具有不同类型含量的溶剂或两种组分的溶剂通过控制流体的混合比而不同于常规方法，包括喷雾干燥含有可生物降解的聚合物的微球体的混合物， 药物，添加剂和具有单一组成的溶剂。 本发明方法可以通过连续一步法制备微球，实现通过具有单一组成的常规微球难以获得的所需药物释放，并且可以简化分别制备几种微球制剂的常规复合方法，然后 以适当的比例混合制剂以实现期望的药物释放。

公开(公告)号：WO2012161497A2

公开(公告)日：2012-11-29

申请号：PCT/KR2012004029

申请日：2012-05-22

Applicant: INCOSPHARM CORP ,  PARK KEE-DON ,  LIM CHAE-JIN ,  YOON SEOK-JEONG ,  KWON SEON-DEOK

Inventor： PARK KEE-DON ,  LIM CHAE-JIN ,  YOON SEOK-JEONG ,  KWON SEON-DEOK

IPC: C07K5/02 ,  A61Q19/00 ,  C07K5/06 ,  C07K5/08 ,  C07K7/06

CPC classification number: C07K5/1019 ,  A61K8/64 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61Q5/00 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08 ,  C07K5/0215 ,  C07K5/06086 ,  C07K5/06104 ,  C07K5/0819 ,  C07K5/1021 ,  C07K14/001

Abstract: The present invention relates to peptide derivatives, or pharmaceutically acceptable salts thereof, having a superior moisturizing effect, and to moisturizing uses thereof. More specifically, the present invention relates to novel peptide derivatives or pharmaceutically acceptable salts thereof, to a method for preparing the derivatives or salts, to a moisturizing cosmetic composition containing the derivatives or salts as active ingredients, and to a pharmaceutical composition for preventing and treating dry skin.

Abstract translation: 本发明涉及具有优异保湿效果的肽衍生物或其药学上可接受的盐，以及其保湿用途。 更具体地，本发明涉及一种新颖的肽衍生物或其药学上可接受的盐，涉及一种制备衍生物或盐的方法，所述方法包含所述衍生物或盐作为活性成分的保湿化妆品组合物和用于预防和治疗的药物组合物 皮肤干燥。