公开(公告)号：WO2009152917A3

公开(公告)日：2009-12-23

申请号：PCT/EP2009/003666

申请日：2009-05-23

申请人： MAX ZELLER SÖHNE AG ,  TOFF, Stephan ,  PARLAR, Harun

发明人： TOFF, Stephan ,  PARLAR, Harun

IPC分类号： C07C67/62 ,  C07C69/533 ,  C07C67/58 ,  A61K31/22 ,  A61P37/08

摘要： Described is a method for slowing the speed of the isomerisation of petasin and neopetasin to isopetasin, and the isomerisation of S-petasin and neo-S-petasin to iso-S-petasin, especially in extracts from plants of the genus Petasites, preferably Petasites hybridus, by the addition of at least one suitable stabilizer and/or the removal of at least one destabilizing substance, e.g. a fatty acid.

公开(公告)号：WO2009152917A2

公开(公告)日：2009-12-23

申请号：PCT/EP2009003666

申请日：2009-05-23

申请人： ZELLER MAX SOEHNE AG ,  TOFF STEPHAN ,  PARLAR HARUN

发明人： TOFF STEPHAN ,  PARLAR HARUN

IPC分类号： C07C67/62 ,  A61K31/22 ,  A61P37/08 ,  C07C67/58 ,  C07C69/533

CPC分类号： A61K9/205 ,  A61K9/2031 ,  C07C67/62 ,  C07C2602/26 ,  C07C69/533

摘要： Described is a method for slowing the speed of the isomerisation of petasin and neopetasin to isopetasin, and the isomerisation of S-petasin and neo-S-petasin to iso-S-petasin, especially in extracts from plants of the genus Petasites, preferably Petasites hybridus, by the addition of at least one suitable stabilizer and/or the removal of at least one destabilizing substance, e.g. a fatty acid.

摘要翻译： 描述了一种降低petasin和neopetasin异构体异速分解速度的方法，以及将S-petasin和neo-S-petasin异构化为异S帕西汀，特别是在Petasites属植物的提取物中，优选Petasites 通过添加至少一种合适的稳定剂和/或去除至少一种不稳定物质，例如， 一种脂肪酸。

公开(公告)号：WO2009152917A4

公开(公告)日：2010-10-21

申请号：PCT/EP2009003666

申请日：2009-05-23

申请人： ZELLER MAX SOEHNE AG ,  TOFF STEPHAN ,  PARLAR HARUN

发明人： TOFF STEPHAN ,  PARLAR HARUN

IPC分类号： C07C67/62 ,  A61K31/22 ,  A61P37/08 ,  C07C67/58 ,  C07C69/533

CPC分类号： A61K9/205 ,  A61K9/2031 ,  C07C67/62 ,  C07C2602/26 ,  C07C69/533

摘要： Described is a method for slowing the speed of the isomerisation of petasin and neopetasin to isopetasin, and the isomerisation of S-petasin and neo-S-petasin to iso-S-petasin, especially in extracts from plants of the genus Petasites, preferably Petasites hybridus, by the addition of at least one suitable stabilizer and/or the removal of at least one destabilizing substance, e.g. a fatty acid.

摘要翻译： 描述了一种方法，用于减缓petasin和neopetasin异构化为异胞磷蛋白的速度，以及S-petasin和neo-S-petasin异构化为iso-S-苹果酸苷，尤其是Petasites属植物的提取物，优选Petasites 通过添加至少一种合适的稳定剂和/或去除至少一种去稳定物质， 一种脂肪酸。