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1.发明申请
公开(公告)号：WO2009094592A2
公开(公告)日：2009-07-30
申请号：PCT/US2009/031909
申请日：2009-01-23
Applicant: PERLEGEN SCIENCES, INC. , COX, David, A. , BEILHARZ, Erica , KONVICKA, Karel , SCHELLENBERG, Gerard, D. , LARSON, Eric , ZHAN, Yiping
Inventor： COX, David, A. , BEILHARZ, Erica , KONVICKA, Karel , SCHELLENBERG, Gerard, D. , LARSON, Eric , ZHAN, Yiping
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , C12Q2600/178 , G06F19/18
Abstract: A collection of polymorphic sites conferring resistance or susceptibility to Alzheimer's disease and diseases related thereto is provided. The sites are useful in methods of diagnosing and treating Alzheimer's disease and related conditions.
Abstract translation: 提供赋予对阿尔茨海默病和与之有关的疾病的抗性或易感性的多态性位点的集合。 这些部位可用于诊断和治疗阿尔茨海默病和相关病症的方法。
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公开(公告)号：WO2009023048A9
公开(公告)日：2009-02-19
申请号：PCT/US2008/005928
申请日：2008-05-09
Applicant: PERLEGEN SCIENCES, INC. , COX, David, R. , FRAZER, Kelly, A. , HINDS, David, A. , HYDE, Craig, L. , THOMPSON, John, F.
Inventor： COX, David, R. , FRAZER, Kelly, A. , HINDS, David, A. , HYDE, Craig, L. , THOMPSON, John, F.
IPC: C12Q1/68
Abstract: Correlations between polymorphisms and metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction arc provided. Methods of diagnosing and treating metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided. Systems and kits for diagnosis and treatment of metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia. diabetes and/or myocardial infarction are provided.
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公开(公告)号：WO2007145992A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/013314
申请日：2007-06-03
Applicant: PERLEGEN SCIENCES, INC. , HINDS, David, A. , COX, David, R. , HYDE, Craig, L. , SAKUL, Hakan
Inventor： HINDS, David, A. , COX, David, R. , HYDE, Craig, L. , SAKUL, Hakan
IPC: C12Q1/70
CPC classification number: C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
Abstract: The invention provides a collection of polymorphic sites associated with response to treatment by an SSRI or placebo in depression patients. The polymorphic sites and others in linkage disequilibrium with them are useful in determining whether to treat a patient with an SSRI or include a patient in a clinical trial to test an SSRI.
Abstract translation: 本发明提供了与抑郁症患者中SSRI或安慰剂治疗反应相关的多态性位点的集合。 与它们连锁不平衡的多态性位点和其他位点可用于确定是否用SSRI治疗患者或在临床试验中包括患者以测试SSRI。
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公开(公告)号：WO2006107670A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/011402
申请日：2006-03-28
Applicant: PERLEGEN SCIENCES, INC. , COX, David, R. , MARGUS, Brad, A.
Inventor： COX, David, R. , MARGUS, Brad, A.
Abstract: Cell and tissue autonomous phenotypes are correlated with genotype information. Correlated genotype information is used to screen individual traits. Methods and systems for correlating cell and tissue autonomous phenotypes to genotype information are provided.
Abstract translation: 细胞和组织自主表型与基因型信息相关。 相关基因型信息用于筛选个体特征。 提供了将细胞和组织自主表型与基因型信息相关联的方法和系统。
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公开(公告)号：WO2006079101A3
公开(公告)日：2006-07-27
申请号：PCT/US2006/002618
申请日：2006-01-23
Applicant: PERLEGEN SCIENCES, INC. , NORVIEL, Vernon, A.
Inventor： NORVIEL, Vernon, A.
Abstract: The present invention discloses methods for combining data on genetic variations and phenotypes of individuals to predict a phenotype-of-interest. The present invention also discloses kits that can be used to determine if an individual has or does not have a phenotype-of-interest. The kit can include at least one diagnostic tool and written instructions.
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Patent Agency Ranking
公开(公告)号：WO2005086770A2
公开(公告)日：2005-09-22
申请号：PCT/US2005007375
申请日：2005-03-03
Applicant: PERLEGEN SCIENCES INC , COX DAVID R , MCCAMISH MARK
Inventor： COX DAVID R , MCCAMISH MARK
Abstract: Several methods are described for assessing an individual's likelihood of developing or exhibiting a multifactorial trait. The methods include determining a plurality of genotypes for the individual at a plurality of biallelic polymorphic loci, using the genotypes to compute a score for the individual, and comparing the score to at least one threshold value.
Abstract translation: 描述了用于评估个体发展或表现多因素性状的可能性的几种方法。 所述方法包括使用基因型来计算个体的分数，并将评分与至少一个阈值进行比较来确定个体在多个双向多态性基因座上的多种基因型。
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公开(公告)号：WO2003057718A3
公开(公告)日：2003-07-17
申请号：PCT/US2003/000441
申请日：2003-01-07
Applicant: PERLEGEN SCIENCES, INC. , COX, David, R. , MARGUS, Bradley, A.
Inventor： COX, David, R. , MARGUS, Bradley, A.
IPC: C12Q1/68
Abstract: Improved systems and methods for performing genetic analyses are provided. Full genomic DNA scans are performed on the genetic DNA from a plurality of individuals to identify genetic variants. For those variants, but not based on a full genetic DNA scan, the variants alone are scanned in additional individuals to identify blocks of the variants that tend to be inherited together.
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公开(公告)号：WO2009055708A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/081172
申请日：2008-10-24
Applicant: PERLEGEN SCIENCES, INC. , FU, Glenn , STUVE, Laura , MONTGOMERY, Julie , SHEEHAN, John , PETHIYAGODA, Charit , OLLMANN, Amy , SHEN, Naiping , KENNEMER, Michael , SPARKS, Andrew, B. , BALLINGER, Dennis
Inventor： FU, Glenn , STUVE, Laura , MONTGOMERY, Julie , SHEEHAN, John , PETHIYAGODA, Charit , OLLMANN, Amy , SHEN, Naiping , KENNEMER, Michael , SPARKS, Andrew, B. , BALLINGER, Dennis
CPC classification number: C12Q1/6806 , C12Q1/6827 , C12Q1/6837 , C12Q2525/191 , C12Q2535/131 , C12Q2565/519 , C12Q2531/113
Abstract: Multiple unique selection probes are provided in a single medium. Each selection probe has a sequence that is complementary to a unique target sequence that may be present in a sample under consideration. For example, each selection probe may be complementary to a sequence that includes one of the SNPs used to genotype an organism. Single-stranded selection probes anneal or hybridize with sample sequences having the unique target sequences specified by the selection probe sequences. Sequences from the sample that do not anneal or hybridize with the selection probes are separated from the bound sequences by an appropriate technique. The bound sequences can then be freed to provide a mixture of isolated target sequences, which can be used as needed for the application at hand.
Abstract translation: 在单个介质中提供多个独特的选择探针。 每个选择探针具有与可能存在于所考虑的样品中的唯一靶序列互补的序列。 例如，每个选择探针可以与包括用于基因型生物体的一个SNP的序列互补。 单链选择探针与具有由选择探针序列指定的唯一靶序列的样品序列退火或杂交。 来自不退火或与选择探针杂交的样品的序列通过适当的技术与结合的序列分离。 然后可以释放结合的序列以提供分离的靶序列的混合物，其可根据需要用于手边的应用。
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公开(公告)号：WO2007100919A3
公开(公告)日：2008-11-06
申请号：PCT/US2007005411
申请日：2007-03-01
Applicant: PERLEGEN SCIENCES INC , BALLINGER DENNIS , KONVICKA KAREL , BIERUT LAURA JEAN , RICE JOHN , SACCONE SCOTT
Inventor： BALLINGER DENNIS , KONVICKA KAREL , BIERUT LAURA JEAN , RICE JOHN , SACCONE SCOTT
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , A61K49/0004 , C12Q2600/112 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N33/5088 , G01N33/6893 , G01N2500/00
Abstract: Correlations between polymorphisms and addiction are provided. Methods of diagnosing, prognosing, and treating addiction are provided. Systems and kits for diagnosis, prognosis and treatment of addiction are provided. Methods of identifying addiction modulators are also described.
Abstract translation: 提供多态性与成瘾之间的相关性。 提供诊断，预后和治疗成瘾的方法。 提供了用于诊断，预后和治疗成瘾的系统和试剂盒。 还描述了识别成瘾调节剂的方法。
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公开(公告)号：WO2007145992A8
公开(公告)日：2008-03-13
申请号：PCT/US2007013314
申请日：2007-06-05
Applicant: PERLEGEN SCIENCES INC , HINDS DAVID A , COX DAVID R , HYDE CRAIG L , SAKUL HAKAN
Inventor： HINDS DAVID A , COX DAVID R , HYDE CRAIG L , SAKUL HAKAN
IPC: C12Q1/70
CPC classification number: C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
Abstract: The invention provides a collection of polymorphic sites associated with response to treatment by an SSRI or placebo in depression patients. The polymorphic sites and others in linkage disequilibrium with them are useful in determining whether to treat a patient with an SSRI or include a patient in a clinical trial to test an SSRI.
Abstract translation: 本发明提供了与SSRI或安慰剂对抑郁症患者的治疗反应有关的多态性位点的集合。 与它们处于连锁不平衡中的多态性位点和其他位点可用于确定是否用SSRI治疗患者或者在临床试验中包括患者以测试SSRI。
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