公开(公告)号：WO2013036867A3

公开(公告)日：2013-03-14

申请号：PCT/US2012/054307

申请日：2012-09-07

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  JAMIESON, Catriona, H. ,  JIANG, Qingfei ,  FRAZER, Kelly, A. ,  BARRETT, Christian ,  SADARANGANI, Anil ,  SHIH, Alice ,  COURT, Angele

Inventor： JAMIESON, Catriona, H. ,  JIANG, Qingfei ,  FRAZER, Kelly, A. ,  BARRETT, Christian ,  SADARANGANI, Anil ,  SHIH, Alice ,  COURT, Angele

IPC: A61K48/00 ,  A61K38/17 ,  A61K38/16 ,  A61K31/7105 ,  A61K31/7088 ,  A61P35/00

Abstract: In alternative embodiments, the invention provides compositions and methods for inhibiting or ablating cancer stem cells. In alternative embodiments, the invention provides compositions and methods for inhibiting the action of double-stranded RNA-specific adenosine deaminases, or ADAR, enzymes. In alternative embodiments, the invention provides compositions and methods for treating, ameliorating or preventing diseases and conditions responsive to the inhibition of cell differentiation and/or self-renewal of dysfunctional cells, cancer cells, leukemia cells, hematopoietic stem cells or cancer stem cells, e.g., leukemia or Chronic Myeloid Leukemia (CML). In alternative embodiments, the invention provides compositions and methods for inhibiting a Sonic Hedgehog (Shh) pathway, e.g., by using a Smoothened (SMO) protein inhibitor. In alternative embodiments, the invention provides compositions and methods for measuring or determining, or predicting, chronic myelogenous leukemia (CML) progression, Leukemic Stem Cell (LSC) generation and/or tyrosine kinase inhibitor resistance. In alternative embodiments, the invention provides compositions and methods for determining or measuring the effectiveness of a treatment, a drug, a therapy or a diet for eliminating, killing or reducing the amounts of a leukemic stem cell (LSC) or cells.

公开(公告)号：WO2009023048A2

公开(公告)日：2009-02-19

申请号：PCT/US2008005928

申请日：2008-05-09

Applicant: PERLEGEN SCIENCES INC ,  COX DAVID R ,  FRAZER KELLY A ,  HINDS DAVID A ,  HYDE CRAIG L ,  THOMPSON JOHN F

Inventor： COX DAVID R ,  FRAZER KELLY A ,  HINDS DAVID A ,  HYDE CRAIG L ,  THOMPSON JOHN F

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/172

Abstract: Correlations between polymorphisms and metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction arc provided. Methods of diagnosing and treating metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided. Systems and kits for diagnosis and treatment of metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia. diabetes and/or myocardial infarction are provided.

Abstract translation: 提供了多态性与代谢综合征，胰岛素抵抗，肥胖症，高血压，血脂异常，糖尿病和/或心肌梗塞之间的相关性。 提供了诊断和治疗代谢综合征，胰岛素抵抗，肥胖症，高血压，血脂异常，糖尿病和/或心肌梗塞的方法。 诊断和治疗代谢综合征，胰岛素抵抗，肥胖，高血压，血脂异常的系统和试剂盒。 提供糖尿病和/或心肌梗塞。

公开(公告)号：WO2004070061A1

公开(公告)日：2004-08-19

申请号：PCT/US2003/014799

申请日：2003-05-08

Applicant: PERLEGEN SCIENCES, INC. ,  FRAZER, Kelly, A. ,  PATIL, Nila ,  SHEEHAN, John

Inventor： FRAZER, Kelly, A. ,  PATIL, Nila ,  SHEEHAN, John

IPC: C12Q1/68

CPC classification number: C12Q1/6809 ,  G06F19/18 ,  G06F19/22

Abstract: The present invention provides methods for determining sequence similarity (conserved sequences) between nucleic acids from a first organism and nucleic acids from a second, different organism without having to know a priori the nucleic acid sequence from the second, different organism. The first nucleic acid can be from any organism where the sequence of the nucleic acid is known and the second nucleic acid can be from any organism. The method involves determining which bases from the second nucleic acid are identical to the first nucleic acid, and allows one to determine the sequence of portions of the second nucleic acid. The invention is useful for identifying putative functional regions or putative organism-sequences in a genome.

Abstract translation: 本发明提供了用于确定来自第一生物体的核酸和来自第二种不同生物体的核酸之间的序列相似性（保守序列）的方法，而不必先验地知道来自第二种不同生物体的核酸序列。 第一核酸可以来自任何已知核酸序列并且第二核酸可以来自任何生物体的生物体。 所述方法包括确定来自第二核酸的哪些碱基与第一核酸相同，并且允许确定第二核酸的部分序列。 本发明可用于在基因组中鉴定推定的功能区域或推定的生物体序列。

公开(公告)号：WO2009023048A3

公开(公告)日：2010-01-14

申请号：PCT/US2008005928

申请日：2008-05-09

Applicant: PERLEGEN SCIENCES INC ,  COX DAVID R ,  FRAZER KELLY A ,  HINDS DAVID A ,  HYDE CRAIG L ,  THOMPSON JOHN F

Inventor： COX DAVID R ,  FRAZER KELLY A ,  HINDS DAVID A ,  HYDE CRAIG L ,  THOMPSON JOHN F

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/172

Abstract: Correlations between polymorphisms and metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction arc provided. Methods of diagnosing and treating metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided. Systems and kits for diagnosis and treatment of metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia. diabetes and/or myocardial infarction are provided.

Abstract translation: 提供多态性与代谢综合征之间的相关性，胰岛素抵抗，肥胖，高血压，血脂异常，糖尿病和/或心肌梗塞。 提供诊断和治疗代谢综合征，胰岛素抵抗，肥胖，高血压，血脂异常，糖尿病和/或心肌梗死的方法。 用于诊断和治疗代谢综合征，胰岛素抵抗，肥胖，高血压，血脂异常的系统和试剂盒。 提供糖尿病和/或心肌梗塞。

公开(公告)号：WO2004101806A3

公开(公告)日：2006-10-05

申请号：PCT/US2004010699

申请日：2004-04-06

Applicant: PERLEGEN SCIENCES INC ,  FRAZER KELLY A ,  COX DAVID A ,  TAO HENG ,  PANT KRISHNA ,  NILSEN GEOFFREY

Inventor： FRAZER KELLY A ,  COX DAVID A ,  TAO HENG ,  PANT KRISHNA ,  NILSEN GEOFFREY

IPC: C12Q1/68

CPC classification number: C12Q1/6809 ,  C12Q1/6827 ,  C12Q2531/113 ,  C12Q2565/501

Abstract: The invention provides methods of analyzing genes for differential relative allelic expression patterns. Haplotype blocks throughout the genomes of individuals are analyzed to identify haplotype patterns that are associated with specific differential relative allelic expression patterns. Haplotype blocks that contain associated haplotype patterns may be further investigated to identify genes or variants of genes involved in differential relative allelic expression patterns.

Abstract translation: 本发明提供了分析差异相对等位基因表达模式的基因的方法。 分析个体基因组中的单倍型区域，以鉴定与特异性差异相对等位基因表达模式相关联的单倍型模式。 可以进一步研究包含相关单体型模式的单倍型区域，以鉴定参与差异相对等位基因表达模式的基因的基因或变体。

公开(公告)号：WO2013036867A2

公开(公告)日：2013-03-14

申请号：PCT/US2012054307

申请日：2012-09-07

Applicant: UNIV CALIFORNIA ,  JAMIESON CATRIONA H ,  JIANG QINGFEI ,  FRAZER KELLY A ,  BARRETT CHRISTIAN ,  SADARANGANI ANIL ,  SHIH ALICE ,  COURT ANGELE

Inventor： JAMIESON CATRIONA H ,  JIANG QINGFEI ,  FRAZER KELLY A ,  BARRETT CHRISTIAN ,  SADARANGANI ANIL ,  SHIH ALICE ,  COURT ANGELE

IPC: A61K48/00

CPC classification number: C07K16/40 ,  A61K31/7105 ,  A61K31/713 ,  A61K38/00 ,  C07K2/00 ,  C12N9/80 ,  C12N15/1137 ,  C12Y305/04004 ,  G01N33/57426 ,  G01N33/57484 ,  G01N2333/4703 ,  G01N2800/52

Abstract: In alternative embodiments, the invention provides compositions and methods for inhibiting or ablating cancer stem cells. In alternative embodiments, the invention provides compositions and methods for inhibiting the action of double-stranded RNA-specific adenosine deaminases, or ADAR, enzymes. In alternative embodiments, the invention provides compositions and methods for treating, ameliorating or preventing diseases and conditions responsive to the inhibition of cell differentiation and/or self-renewal of dysfunctional cells, cancer cells, leukemia cells, hematopoietic stem cells or cancer stem cells, e.g., leukemia or Chronic Myeloid Leukemia (CML). In alternative embodiments, the invention provides compositions and methods for inhibiting a Sonic Hedgehog (Shh) pathway, e.g., by using a Smoothened (SMO) protein inhibitor. In alternative embodiments, the invention provides compositions and methods for measuring or determining, or predicting, chronic myelogenous leukemia (CML) progression, Leukemic Stem Cell (LSC) generation and/or tyrosine kinase inhibitor resistance. In alternative embodiments, the invention provides compositions and methods for determining or measuring the effectiveness of a treatment, a drug, a therapy or a diet for eliminating, killing or reducing the amounts of a leukemic stem cell (LSC) or cells.

Abstract translation: 在替代实施方案中，本发明提供了用于抑制或消除癌症干细胞的组合物和方法。 在替代实施方案中，本发明提供了用于抑制双链RNA特异性腺苷脱氨酶或ADAR酶的作用的组合物和方法。 在可选的实施方案中，本发明提供了用于治疗，改善或预防对抑制功能失调细胞，癌细胞，白血病细胞，造血干细胞或癌症干细胞的细胞分化和/或自我更新有响应的疾病和病症的组合物和方法， 如白血病或慢性粒细胞白血病（CML）。 在可选的实施方案中，本发明提供了用于抑制Sonic Hedgehog（Shh）途径的组合物和方法，例如通过使用Smoothened（SMO）蛋白抑制剂。 在可选的实施方案中，本发明提供了用于测量或确定或预测慢性骨髓性白血病（CML）进展，白血病干细胞（LSC）产生和/或酪氨酸激酶抑制剂抗性的组合物和方法。 在可选的实施方案中，本发明提供了用于确定或测量用于消除，杀死或减少白血病干细胞（LSC）或细胞的量的治疗，药物，疗法或饮食的有效性的组合物和方法。

公开(公告)号：WO2009023048A9

公开(公告)日：2009-02-19

申请号：PCT/US2008/005928

申请日：2008-05-09

Applicant: PERLEGEN SCIENCES, INC. ,  COX, David, R. ,  FRAZER, Kelly, A. ,  HINDS, David, A. ,  HYDE, Craig, L. ,  THOMPSON, John, F.

Inventor： COX, David, R. ,  FRAZER, Kelly, A. ,  HINDS, David, A. ,  HYDE, Craig, L. ,  THOMPSON, John, F.

IPC: C12Q1/68

Abstract: Correlations between polymorphisms and metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction arc provided. Methods of diagnosing and treating metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided. Systems and kits for diagnosis and treatment of metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia. diabetes and/or myocardial infarction are provided.

公开(公告)号：WO2004101806A2

公开(公告)日：2004-11-25

申请号：PCT/US2004/010699

申请日：2004-04-06

Applicant: PERLEGEN SCIENCES, INC. ,  FRAZER, Kelly, A. ,  COX, David, A. ,  TAO, Heng ,  PANT, Krishna ,  NILSEN, Geoffrey

Inventor： FRAZER, Kelly, A. ,  COX, David, A. ,  TAO, Heng ,  PANT, Krishna ,  NILSEN, Geoffrey

IPC: C12Q

CPC classification number: C12Q1/6809 ,  C12Q1/6827 ,  C12Q2531/113 ,  C12Q2565/501

Abstract: The invention provides methods of analyzing genes for differential relative allelic expression patterns. Haplotype blocks throughout the genomes of individuals are analyzed to identify haplotype patterns that are associated with specific differential relative allelic expression patterns. Haplotype blocks that contain associated haplotype patterns may be further investigated to identify genes or variants of genes involved in differential relative allelic expression patterns.

Abstract translation: 本发明提供了分析差异相对等位基因表达模式的基因的方法。 分析个体基因组中的单倍型区域，以鉴定与特异性差异相对等位基因表达模式相关联的单倍型模式。 可以进一步研究包含相关单体型模式的单倍型区域，以鉴定参与差异相对等位基因表达模式的基因的基因或变体。