公开(公告)号：WO9959541A2

公开(公告)日：1999-11-25

申请号：PCT/EP9903002

申请日：1999-05-04

Applicant: BASF AG ,  HEGER ROBERT ,  AUWETER HELMUT ,  PFLUEGER PETER ,  BREITENBACH JOERG ,  BINDER RUDOLF ,  ZEIDLER JUERGEN ,  BERNDL GUNTHER

Inventor： HEGER ROBERT ,  AUWETER HELMUT ,  PFLUEGER PETER ,  BREITENBACH JOERG ,  BINDER RUDOLF ,  ZEIDLER JUERGEN ,  BERNDL GUNTHER

IPC: A61K9/16 ,  A61K9/51 ,  A61K38/00 ,  A61K38/13 ,  A61K47/14 ,  A61K47/36 ,  A61P37/06 ,  A61K9/00

CPC classification number: A61K9/5123 ,  A61K9/0095 ,  A61K9/1617 ,  A61K9/1658 ,  A61K9/5169 ,  A61K38/13

Abstract: The invention relates to solid or liquid cyclosporin preparations for oral administration in which the cyclosporin is presented in the form of solid X-amorphous particles embedded in a coating matrix in a colloidally dispersed manner.

Abstract translation: 存在嵌入在涂层基质的固体或液体环孢菌素制剂用于口服给药的，其中以固体，X射线无定形的颗粒形式的环孢菌素kolloidaldispers。

公开(公告)号：WO2007048730A8

公开(公告)日：2008-06-05

申请号：PCT/EP2006067473

申请日：2006-10-17

Applicant: BASF SE ,  MARTIN INGRID ,  AUWETER HELMUT ,  KOLTZENBURG SEBASTIAN ,  SCHAEFER ANSGAR ,  PFLUEGER PETER ,  BLANZ BIRGIT ,  GOEDEL WERNER A

Inventor： MARTIN INGRID ,  AUWETER HELMUT ,  KOLTZENBURG SEBASTIAN ,  SCHAEFER ANSGAR ,  PFLUEGER PETER ,  BLANZ BIRGIT ,  GOEDEL WERNER A

IPC: A01N25/04 ,  A01N25/28 ,  A01N43/40 ,  A01N43/653 ,  A01N47/24 ,  A01N47/34 ,  A01N53/00 ,  A01P3/00 ,  A01P7/00 ,  A01P13/00

CPC classification number: A01N25/04 ,  A01N25/28 ,  A01N2300/00

Abstract: The present invention encompasses aqueous dispersions comprising a nanoparticulate formulation of active crop protection ingredients, in which the nanoparticles have core-shell structures with a mean particle diameter of 0.05 to 2.0 µm and the active crop protection ingredient is present in the core in X-ray-amorphous form together with one or more polymers, and the shell consists of a stabilized envelope matrix preparable by a process which is characterized in that (a) a solution of the active crop protection ingredient in a water-miscible organic solvent is prepared, (b) the solution obtained in step (a) is mixed with the core polymer or a solution of the core polymer in a water-miscible organic solvent, the polymer being insoluble or only partly soluble in water or aqueous solutions or water-solvent mixtures; and (c) the mixture resulting from (b) is contacted with an aqueous solution comprising components of the envelope matrix.

Abstract translation: 本发明包括水性分散体，其包括植物保护剂的纳米微粒制剂，其中表现出与0.05微米至2.0微米的平均粒径和在芯透视作物保护试剂与一种或多种聚合物一起无定形纳米粒子的核 - 壳结构的 和壳由一个稳定涂层基质通过一个过程，其特征在于：（a）制备在水混溶性有机溶剂中的作物保护剂的溶液，（b）以步骤溶液中制备的（a）中获得的与芯聚合物 混合或在与水混溶的有机溶剂中的核聚合物，其中所述聚合物是不溶的或仅部分可溶于水或水溶液或水 - 溶剂混合物中的溶液; 和（c）从（b）中得到的混合用包含在接触的涂层基质的成分的水溶液带来的。