公开(公告)号：WO2014191831A3

公开(公告)日：2014-12-04

申请号：PCT/IB2014/001350

申请日：2014-05-30

Applicant: PIXCELL MEDICAL TECHNOLOGIES LTD.

Inventor： BRANSKY, Avishay ,  SHLOMO, Liron

IPC: B01L3/00 ,  G01N1/20

Abstract: A cartridge configured for use in a blood analyzer is provided. The cartridge may include a substantially rigid frame, a flow path within the rigid frame, at least one opening m the substantially rigid frame configured to align and stabilize a capillary tube, and a seal within the flow path. The seal may be configured to temporarily obstruct flow through at least a portion of the flow path. The seal may also be configured to open in response to a force exerted via a capillary tube inserted into the at least one opening.

公开(公告)号：WO2020141463A2

公开(公告)日：2020-07-09

申请号：PCT/IB2020/000026

申请日：2020-01-02

Applicant: PIXCELL MEDICAL TECHNOLOGIES LTD.

Inventor： MUZYKOVSKI, Vladimir ,  MAROM, Barak ,  BRANSKY, Avishay

IPC: G01N33/53

Abstract: The invention relates to systems and methods for performing one or more immunoassays on a fluid sample and performing image analysis on the fluid sample as the sample is flowing so as to obtain measurements related to one or more target analytes based on image analysis. The systems and methods include a disposable fluidic device, such as a cartridge, configured to be loaded with a fluid sample and perform one or more assays on the fluid sample. The cartridge is further configured to flow a volume of fluid sample, undergoing, or having undergone, an assay, through a portion thereof to be subsequently analyzed by an analysis instrument. The analysis instrument is configured to capture images of the fluid sample as it is flowing through a portion of the cartridge and subsequently analyze the images so as to obtain measurements of one or more target analytes within the fluid sample.

公开(公告)号：WO2020141463A3

公开(公告)日：2020-07-09

申请号：PCT/IB2020/000026

申请日：2020-01-02

Applicant: PIXCELL MEDICAL TECHNOLOGIES LTD.

Inventor： MUZYKOVSKI, Vladimir ,  MAROM, Barak ,  BRANSKY, Avishay

IPC: G01N33/53

Abstract: The invention relates to systems and methods for performing one or more immunoassays on a fluid sample and performing image analysis on the fluid sample as the sample is flowing so as to obtain measurements related to one or more target analytes based on image analysis. The systems and methods include a disposable fluidic device, such as a cartridge, configured to be loaded with a fluid sample and perform one or more assays on the fluid sample. The cartridge is further configured to flow a volume of fluid sample, undergoing, or having undergone, an assay, through a portion thereof to be subsequently analyzed by an analysis instrument. The analysis instrument is configured to capture images of the fluid sample as it is flowing through a portion of the cartridge and subsequently analyze the images so as to obtain measurements of one or more target analytes within the fluid sample.

公开(公告)号：WO2016189381A1

公开(公告)日：2016-12-01

申请号：PCT/IB2016/000782

申请日：2016-05-20

Applicant: PIXCELL MEDICAL TECHNOLOGIES LTD

Inventor： BRANSKY, Avishay ,  SHLOMO, Liron

IPC: G01N33/52 ,  G01N33/53

CPC classification number: B01L3/50273 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/0684 ,  B01L2300/0609 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0406 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0493 ,  G01N21/05 ,  G01N21/51 ,  G01N33/521 ,  G01N33/5302 ,  G01N35/00029 ,  G01N35/04 ,  G01N2021/058 ,  G01N2021/513 ,  G01N2035/00039

Abstract: A fluid analysis system may include a stage configured to receive a sample holder including a fluid sample to be analyzed, The fluid analysis system may also include a fluid analyzer configured to monitor at least one characteristic of the fluid sample to be analyzed; and an inclined rail; wherein the stage is configured to move along the inclined rail to cause the sample holder to move with a first component of motion along an analysts axis of the fluid analyzer and simultaneously with a second component of motion orthogonal to the analysis axis of the fluid analyzer, wherein the first component of motion affects a focus of the fluid analyzer relative to at least one constituent of the fluid sample to be analyzed.

Abstract translation: 流体分析系统可以包括配置成接收包括要分析的流体样品的样品架的载物台。流体分析系统还可以包括流体分析器，该流体分析器被配置为监测待分析的流体样品的至少一个特性; 和斜轨; 其中所述台架被构造成沿着所述倾斜轨道移动，以使所述样品保持器沿着所述流体分析器的分析器轴线的第一运动分量移动，并且与与所述流体分析器的分析轴正交的运动的第二分量同时移动， 其中所述第一运动分量相对于要分析的所述流体样品的至少一个成分影响所述流体分析器的焦点。

公开(公告)号：WO2012120506A2

公开(公告)日：2012-09-13

申请号：PCT/IL2012/000120

申请日：2012-03-08

Applicant: PIXCELL MEDICAL TECHNOLOGIES LTD. ,  BRANSKY, Avishay ,  SHLOMO, Liron

Inventor： BRANSKY, Avishay ,  SHLOMO, Liron

IPC: B01L3/00

CPC classification number: G01N1/2035 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0683 ,  G01N33/86

Abstract: The invention discloses a disposable cartridge for preparing a sample fluid containing cells for analysis. The cartridge comprises one or more parallel preparation units, each preparation unit comprises one or more chambers enclosed between seals and connected in series. Each chamber is configured for receiving an input fluid, performing a procedure affecting the fluid thereby generating an output fluid, and releasing the output fluid. A first chamber of the one or more chambers is a pressable chamber coupled to a first opening, while a last chamber of the one or more chambers is coupled to a second opening. The input fluid of the first chamber is the sample fluid. The one or more preparation units are coupleable to a compartment for performing analysis of the respective output fluids convey able via the second openings.

Abstract translation: 本发明公开了一种用于制备含有用于分析的细胞的样品流体的一次性盒。 墨盒包括一个或多个并行准备单元，每个准备单元包括一个或多个封闭在密封件之间并串联连接的腔室。 每个室被构造成用于接收输入流体，执行影响流体的过程，从而产生输出流体，以及释放输出流体。 一个或多个室的第一室是联接到第一开口的可压缩室，而一个或多个室的最后一个室联接到第二开口。 第一室的输入流体是样品流体。 一个或多个制备单元可连接到隔室，用于对通过第二开口输送的各个输出流体进行分析。

公开(公告)号：WO2020128549A1

公开(公告)日：2020-06-25

申请号：PCT/IB2018/001528

申请日：2018-12-17

Applicant: PIXCELL MEDICAL TECHNOLOGIES LTD.

Inventor： BRANSKY, Avishay ,  SHLOMO, Liron

IPC: G01N35/10 ,  G01N1/02 ,  G01N1/10 ,  G01N1/14

Abstract: The invention relates to a device for extracting a fluid sample from a closed chamber and providing access to a volume of the extracted fluid sample for subsequent collection via a sampler device associated with a cartridge for delivering the volume of extracted fluid sample to a compatible diagnostic instrument for analyzing the fluid sample.

公开(公告)号：WO2016128843A2

公开(公告)日：2016-08-18

申请号：PCT/IB2016/000753

申请日：2016-01-13

Applicant: PIXCELL MEDICAL TECHNOLOGIES LTD.

Inventor： BRANSKY, Avishay ,  SHLOMO, Liron ,  ROTEM, Nir

IPC: G01N33/50

CPC classification number: B01L3/502715 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2300/046 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/087 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/123 ,  B01L2400/049 ,  B01L2400/0683

Abstract: A disposable cartridge may have a fluid analysis chip for receiving a fluid to be analyzed. The fluid analysis chip may be attached to a fluid preparation unit of the disposable cartridge and may include a base layer. The fluid analysis chip may also include a spacer layer disposed over the base layer, the spacer layer including a microchannel formed therein, the microchannel being configured to guide a flow of the fluid to be analyzed within the fluid analysis chip. The fluid analysis chip may also include a cap layer disposed over the spacer layer, the cap layer including an inlet and an outlet for establishing fluid communication with the microchannel included in the spacer layer, and an interface layer disposed over the cap layer, the interface layer being configured to attach the fluid analysis chip to the fluid preparation unit of the disposable cartridge.

Abstract translation: 一次性盒可具有用于接收待分析流体的流体分析芯片。 流体分析芯片可以附接到一次性盒的流体制备单元，并且可以包括基底层。 流体分析芯片还可以包括设置在基层之上的间隔层，间隔层包括形成在其中的微通道，微通道被配置为引导待分析的流体在流体分析芯片内的流动。 流体分析芯片还可以包括设置在间隔层上的盖层，盖层包括用于建立与包括在间隔层中的微通道的流体连通的入口和出口以及设置在盖层上的界面层，界面层 层被构造成将流体分析芯片附接到一次性盒的流体制备单元。

公开(公告)号：WO2012120506A3

公开(公告)日：2013-05-16

申请号：PCT/IL2012000120

申请日：2012-03-08

Applicant: PIXCELL MEDICAL TECHNOLOGIES LTD ,  BRANSKY AVISHAY ,  SHLOMO LIRON

Inventor： BRANSKY AVISHAY ,  SHLOMO LIRON

IPC: B01L3/00

CPC classification number: G01N1/2035 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0683 ,  G01N33/86

Abstract: The invention discloses a disposable cartridge for preparing a sample fluid containing cells for analysis. The cartridge comprises one or more parallel preparation units, each preparation unit comprises one or more chambers enclosed between seals and connected in series. Each chamber is configured for receiving an input fluid, performing a procedure affecting the fluid thereby generating an output fluid, and releasing the output fluid. A first chamber of the one or more chambers is a pressable chamber coupled to a first opening, while a last chamber of the one or more chambers is coupled to a second opening. The input fluid of the first chamber is the sample fluid. The one or more preparation units are coupleable to a compartment for performing analysis of the respective output fluids convey able via the second openings.

Abstract translation: 本发明公开了一种用于制备含有用于分析的细胞的样品流体的一次性盒。 墨盒包括一个或多个并行准备单元，每个准备单元包括一个或多个封闭在密封件之间并串联连接的腔室。 每个室被构造成用于接收输入流体，执行影响流体的过程，从而产生输出流体，以及释放输出流体。 一个或多个室的第一室是联接到第一开口的可压缩室，而一个或多个室的最后一个室联接到第二开口。 第一室的输入流体是样品流体。 一个或多个制备单元可连接到隔室，用于对通过第二开口输送的各个输出流体进行分析。