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    SYSTEMS AND METHODS FOR INJECTION OF BIOLOGICAL SPECIMENS
    4.
    发明申请
    SYSTEMS AND METHODS FOR INJECTION OF BIOLOGICAL SPECIMENS 审中-公开
    用于注射生物样本的系统和方法

    公开(公告)号：WO2018081298A1

    公开(公告)日：2018-05-03

    申请号：PCT/US2017/058337

    申请日：2017-10-25

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： NOVAK, Richard ,  CLAUSON, Susan ,  KESHARI, Vishal ,  INGBER, Donald, E.

    IPC: C12M1/00

    CPC classification number: C12M33/04 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502784 ,  B01L2200/0621 ,  B01L2200/16 ,  B01L2300/0672 ,  B01L2400/0457 ,  B01L2400/0478 ,  B01L2400/0622 ,  C12M1/00

    Abstract: A device for injecting biological specimens includes (i) a top casing; (ii) a hopper disposed in the top casing; (iii) a bottom casing disposed below the top casing, the bottom casing defining a chamber and an outlet; (iv) a slidable carriage at least partially disposed within the chamber, the slidable carriage defining a cavity and a needle guide; and (v) a needle disposed within the needle guide. The cavity is configured, upon linear translation of the slidable carriage within the chamber toward the needle, to align with and receive a biological specimen from the hopper that is penetrated by the needle upon further linear translation of the slidable carriage toward the needle. The cavity is further configured to align with the outlet upon a reverse linear translation of the slidable carriage away from the needle after the biological specimen is penetrated.

    Abstract translation: 用于注射生物标本的装置包括（i）顶部壳体; （ii）设置在顶部壳体中的料斗; （iii）设置在顶部壳体下方的底部壳体，底部壳体限定腔室和出口; （iv）至少部分地设置在所述室内的可滑动托架，所述可滑动托架限定空腔和针引导件; 和（v）布置在针导向器内的针。 在腔室内的滑动滑架朝着针头线性平移时，空腔被配置为与滑动支架朝向针头进一步线性平移时来自漏斗的生物样本对齐并从其接收生物样本。 腔体进一步构造成在生物样本被穿透之后，在滑动托架反向线性平移远离针时与出口对齐。

    METHOD AND SYSTEMS FOR A SENSOR PATCH WITH EMBEDDED MICROFLUIDICS FOR MONITORING OF FLUID BIOMARKERS
    5.
    发明申请
    METHOD AND SYSTEMS FOR A SENSOR PATCH WITH EMBEDDED MICROFLUIDICS FOR MONITORING OF FLUID BIOMARKERS 审中-公开
    用于监测流体生物标记的具有嵌入式微流体传感器补丁的方法和系统

    公开(公告)号：WO2018067412A1

    公开(公告)日：2018-04-12

    申请号：PCT/US2017/054599

    申请日：2017-09-29

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： LENIGK, Ralf ,  ALIZADEH, Azar ,  BURNS, Andrew Arthur Paul ,  NAGRAJ, Nandini ,  GETTINGS, Rachel

    IPC: A61B5/145 ,  B01L3/00

    CPC classification number: A61B5/14517 ,  B01L3/50273 ,  B01L3/505 ,  B01L2300/023 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0427

    Abstract: Various methods and systems are provided for monitoring body fluid biomarkers with a wearable device. In one example, the wearable devices includes a sensor adapted to sense the body fluid biomarkers; a microfluidics module including a fluid collector adapted to collect fluid from a subject to which the wearable device is attached, a sensor volume in fluid communication with the sensor, and a wick adapted to wick collected fluid away from the sensor volume, the sensor volume arranged downstream of the fluid collector and upstream of the wick; and an electronics module electrically coupled with the sensor and including a wireless device adapted to wirelessly transfer sensor data received from the sensor.

    Abstract translation: 提供了各种方法和系统以用可穿戴设备监测体液生物标记。 在一个示例中，可穿戴设备包括适于感测体液生物标记的传感器; 微流体模块，所述微流体模块包括流体收集器，所述流体收集器适于收集来自所述可穿装置附接到的对象的流体，与所述传感器流体连通的传感器体积以及适于将收集的流体芯吸离开所述传感器体积的芯，所述传感器体积布置 流体收集器的下游和芯的上游; 以及与所述传感器电耦合的电子模块，所述电子模块包括适于无线地传输从所述传感器接收的传感器数据的无线设备。

    MICROFLUIDIC DEVICES
    8.
    发明申请
    MICROFLUIDIC DEVICES 审中-公开
    MICROFLUIDIC设备

    公开(公告)号：WO2018017120A1

    公开(公告)日：2018-01-25

    申请号：PCT/US2016/043528

    申请日：2016-07-22

    Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

    Inventor： GOVYADINOV, Alexander

    IPC: G01N33/487 ,  F04B19/04

    CPC classification number: F04B19/04 ,  B01L3/50273 ,  B01L2300/088 ,  B01L2400/0439 ,  B01L2400/0442 ,  B01L2400/0496 ,  B01L2400/086 ,  F04B17/00 ,  F04B17/003 ,  F04B17/03 ,  F04B19/006 ,  F04B19/24

    Abstract: According to an example, a microfluidic device may include a transport channel having an inlet and an outlet and a plurality of pump loops extending along the transport channel. Each of the plurality of pump loops may include a first branch, a second branch, and a connecting section connecting the first branch and the second branch. The first branch may include a first opening and the second branch may include a second opening, in which the first opening and the second opening are in direct fluid communication with the transport channel. The pump loops may also each include an actuator positioned in the first branch, in which the actuators in the pump loops are to be activated to induce a traveling wave that is to transport the fluid through the transport channel from the inlet to the outlet.

    Abstract translation: 根据一个示例，微流体装置可以包括具有入口和出口的输送通道以及沿着输送通道延伸的多个泵回路。 多个泵回路中的每一个可以包括第一分支，第二分支以及连接第一分支和第二分支的连接部分。 第一分支可以包括第一开口并且第二分支可以包括第二开口，其中第一开口和第二开口与传输通道直接流体连通。 泵回路还可以各自包括位于第一分支中的致动器，其中泵回路中的致动器将被激活以引起行进波，该行波将流体从入口传输到出口通过传输通道。 / p>

    NON-OPTICAL LABEL-FREE BIOMOLECULAR DETECTION AT ELECTRIALLY DISPLACED LIQUID INTERFACES USING INTERFACIAL ELECTROKINETIC TRANSDUCTION (IET)
    9.
    发明申请
    NON-OPTICAL LABEL-FREE BIOMOLECULAR DETECTION AT ELECTRIALLY DISPLACED LIQUID INTERFACES USING INTERFACIAL ELECTROKINETIC TRANSDUCTION (IET) 审中-公开
    使用界面电动力学转换（IET）的电光标签液体界面的非光学标签生物分子检测

    公开(公告)号：WO2017209821A2

    公开(公告)日：2017-12-07

    申请号：PCT/US2017/022005

    申请日：2017-03-13

    Applicant: THE JOHNS HOPKINS UNIVERSITY

    Inventor： GAGNON, Zachary ,  MAVROGIANNIS, Nicholas

    CPC classification number: G01N27/026 ,  B01L3/50273 ,  B01L2300/0636 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0424 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26 ,  G01N27/447

    Abstract: An embodiment in accordance with the present invention is directed to a non-optical, label-free microfluidic biosensor utilizing an electrical liquid interface between two co-flowing liquids - one with a higher conductivity and one with a higher dielectric constant. The analyte-of-interest is in one solution while the receptor is in the adjacent stream. The electric interface acts as a substrate, when an alternating current electric field is applied perpendicularly across the interface, liquid displacement occurs which is frequency dependent. When a reaction occurs at the interface, it alters the electrical properties of the electrical interface, altering the frequency dependent liquid motion, which is then monitored by impedance spectroscopy downstream.

    Abstract translation: 根据本发明的实施方式涉及利用两种共流液体之间的电液界面的非光学无标记微流体生物传感器，一种具有较高电导率，一种具有 更高的介电常数。 目标分析物处于一种溶液中，而受体位于相邻的物流中。 当交流电场垂直地施加在界面上时，电接口用作衬底，发生取决于频率的液体位移。 当界面处发生反应时，它会改变电气界面的电气特性，改变频率相关的液体运动，然后通过阻抗谱下游进行监测。

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