公开(公告)号：WO2012158866A2

公开(公告)日：2012-11-22

申请号：PCT/US2012038252

申请日：2012-05-17

Applicant: UNIV JOHNS HOPKINS ,  POWELL JONATHAN DAVIE ,  HEIKAMP EMILY BETH

Inventor： POWELL JONATHAN DAVIE ,  HEIKAMP EMILY BETH

CPC classification number: A61K31/437 ,  A61K31/4439 ,  A61K31/7088 ,  A61K31/713 ,  A61K38/005 ,  A61K38/02 ,  A61K39/3955

Abstract: The present invention provides novel methods for treating Th2-mediated immune disorders and enhancing Th1-mediated immune responses in a subject comprising administering to the subject, a pharmaceutical composition comprising a serum-glucocorticoid regulated kinase 1 (SGK1) inhibitor and a pharmaceutically acceptable carrier. Methods for treating a wide range of autoimmune diseases are also taught. The present invention also provides methods for augmenting the treatment of subjects having viral or parasitic infections, or which have cancerous tumors.

Abstract translation: 本发明提供治疗Th2介导的免疫病症并增强受试者Th1介导的免疫应答的新方法，包括向受试者施用包含血清 - 糖皮质激素调节激酶1（SGK1）抑制剂和药学上可接受的载体的药物组合物。 还教导了治疗各种自身免疫性疾病的方法。 本发明还提供了用于增加患有病毒或寄生虫感染或具有癌性肿瘤的受试者的治疗的方法。

公开(公告)号：WO2009137095A3

公开(公告)日：2009-11-12

申请号：PCT/US2009/002872

申请日：2009-05-08

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  DRAKE, Charles, George ,  PARDOLL, Drew, M. ,  POWELL, Jonathan, Davie ,  GETNET, Derese ,  HIPKISS, Edward, Luther ,  GROSSO, Joseph, Frank

Inventor： DRAKE, Charles, George ,  PARDOLL, Drew, M. ,  POWELL, Jonathan, Davie ,  GETNET, Derese ,  HIPKISS, Edward, Luther ,  GROSSO, Joseph, Frank

IPC: G01N33/50 ,  G01N33/53 ,  G01N33/48

Abstract: The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate regulatory T cell suppressive activity.

公开(公告)号：WO2012158866A9

公开(公告)日：2012-11-22

申请号：PCT/US2012/038252

申请日：2012-05-17

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  POWELL, Jonathan, Davie ,  HEIKAMP, Emily, Beth

Inventor： POWELL, Jonathan, Davie ,  HEIKAMP, Emily, Beth

IPC: A61K39/395 ,  A61K48/00 ,  A61K38/17 ,  A61K38/16 ,  A61K31/7105 ,  A61K31/7088 ,  A61P17/14 ,  A61P11/06

公开(公告)号：WO2009137095A2

公开(公告)日：2009-11-12

申请号：PCT/US2009002872

申请日：2009-05-08

Applicant: UNIV JOHNS HOPKINS ,  DRAKE CHARLES GEORGE ,  PARDOLL DREW M ,  POWELL JONATHAN DAVIE ,  GETNET DERESE ,  HIPKISS EDWARD LUTHER ,  GROSSO JOSEPH FRANK

Inventor： DRAKE CHARLES GEORGE ,  PARDOLL DREW M ,  POWELL JONATHAN DAVIE ,  GETNET DERESE ,  HIPKISS EDWARD LUTHER ,  GROSSO JOSEPH FRANK

IPC: G01N33/50 ,  G01N33/48 ,  G01N33/53

CPC classification number: C12Q1/6881 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/55561 ,  A61K2039/572 ,  C07K14/4702 ,  C12N15/113 ,  C12N15/117 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2320/31 ,  C12Q2600/136 ,  G01N33/5011

Abstract: The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate regulatory T cell suppressive activity.

Abstract translation: 本发明通常具有用于调节免疫应答的组合物和方法。 在具体实施方案中，这样的组合物和方法调节调节性T细胞抑制活性。