公开(公告)号：WO2011139769A2

公开(公告)日：2011-11-10

申请号：PCT/US2011/034139

申请日：2011-04-27

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  KIM, Young, Jun ,  PARDOLL, Drew, M. ,  DRAKE, Charles, George ,  DAVIS, Meghan ,  FU, Juan

Inventor： KIM, Young, Jun ,  PARDOLL, Drew, M. ,  DRAKE, Charles, George ,  DAVIS, Meghan ,  FU, Juan

IPC: A61K38/17 ,  A61K38/16 ,  A61K38/19 ,  C07K14/535 ,  C12N15/85 ,  A61P35/00

CPC classification number: A61K39/0011 ,  A61K31/7024 ,  A61K31/739 ,  A61K35/12 ,  A61K35/36 ,  A61K35/38 ,  A61K35/39 ,  A61K35/55 ,  A61K38/193 ,  A61K39/0005 ,  A61K45/06 ,  A61K2039/5152 ,  A61K2039/5156 ,  A61K2039/55511 ,  A61K2039/55522 ,  A61K2039/55572 ,  A61K2300/00

Abstract: The invention provides provides immunogenic compositions comprising neoplastic cells expressing a cytokine (GM-CSF) formulated with at least one TLR agonist and methods of using the composition to induce or enhance an immune response.

Abstract translation:

本发明提供了提供了包含表达与至少一种TLR激动剂和使用该组合物，以诱导或增强免疫应答的方法配制的细胞因子（GM-CSF）的肿瘤细胞的免疫原性组合物。

公开(公告)号：WO2009137095A3

公开(公告)日：2009-11-12

申请号：PCT/US2009/002872

申请日：2009-05-08

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  DRAKE, Charles, George ,  PARDOLL, Drew, M. ,  POWELL, Jonathan, Davie ,  GETNET, Derese ,  HIPKISS, Edward, Luther ,  GROSSO, Joseph, Frank

Inventor： DRAKE, Charles, George ,  PARDOLL, Drew, M. ,  POWELL, Jonathan, Davie ,  GETNET, Derese ,  HIPKISS, Edward, Luther ,  GROSSO, Joseph, Frank

IPC: G01N33/50 ,  G01N33/53 ,  G01N33/48

Abstract: The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate regulatory T cell suppressive activity.

公开(公告)号：WO2007022511A3

公开(公告)日：2007-09-13

申请号：PCT/US2006032648

申请日：2006-08-21

Applicant: CERUS CORP ,  UNIV JOHNS HOPKINS ,  PARDOLL DREW M ,  SCHULICK RICHARD D ,  BAHJAT KEITH S ,  BROCKSTEDT DIRK G ,  DUBENSKY THOMAS W JR ,  GIEDLIN MARTIN A ,  JAIN AJAY ,  YOSHIMURA KIYOSHI

Inventor： PARDOLL DREW M ,  SCHULICK RICHARD D ,  BAHJAT KEITH S ,  BROCKSTEDT DIRK G ,  DUBENSKY THOMAS W JR ,  GIEDLIN MARTIN A ,  JAIN AJAY ,  YOSHIMURA KIYOSHI

IPC: A61K35/74 ,  A61P31/00 ,  A61P35/00 ,  A61P37/02

CPC classification number: A61K39/0011 ,  A61K31/675 ,  A61K35/13 ,  A61K35/74 ,  A61K38/193 ,  A61K2039/505 ,  A61K2039/522 ,  A61K2039/55522 ,  A61K2039/55544 ,  C07K16/2812 ,  C07K16/2815 ,  C12N1/36 ,  A61K2300/00 ,  A61K38/00

Abstract: Provided are reagents and methods for administering an attenuated bacterium for use in treating a cancerous or infectious condition. Reagents and methods for administering an attenuated bacterium for use in inducing an immune response against a tumor, cancer cell, or infective agent are further provided. Also provided are methods of diagnosis and kits.

Abstract translation: 提供了用于施用用于治疗癌症或感染症状的减毒细菌的试剂和方法。 还提供了用于施用减毒细菌的试剂和方法，所述减毒细菌用于诱导针对肿瘤，癌细胞或感染剂的免疫应答。 还提供了诊断和试剂盒的方法。

公开(公告)号：WO2004078928A2

公开(公告)日：2004-09-16

申请号：PCT/US2004006133

申请日：2004-03-01

Applicant: PARDOLL DREW M ,  HUANG CHING-TAI ,  VIGNALI DARIO A ,  WORKMAN GREG J ,  POWELL JONATHAN ,  DRAKE CHARLES C

Inventor： PARDOLL DREW M ,  HUANG CHING-TAI ,  VIGNALI DARIO A ,  WORKMAN GREG J ,  POWELL JONATHAN ,  DRAKE CHARLES C

IPC: A01N43/04 ,  A61K31/70 ,  A61K39/00 ,  A61K39/38 ,  A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C12N20060101 ,  C12N5/0783 ,  C12P21/08 ,  G01N33/53 ,  C12N

CPC classification number: C07K16/2803 ,  A01K67/0271 ,  A01K67/0276 ,  A01K2267/0381 ,  A61K39/0011 ,  A61K39/3955 ,  A61K39/39558 ,  A61K2035/122 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/5156 ,  A61K2039/55516 ,  C07K14/70503 ,  C07K16/18 ,  C07K16/42 ,  C12N5/0636 ,  C12N2501/599 ,  C12N2510/00 ,  C12N2799/027

Abstract: Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Treg in vivo requires identification of Treg selective receptors. A comparative analysis of gene expression arrays from antigen specific CD4+ T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg selective expression of LAG-3 (CD223), a CD4-related molecule that binds MHC class II. LAG-3 expression on CD4+ T cells correlates with the cells' in vitro suppressor activity, and ectopic expression of LAG-3 on CD4 T cells confers suppressor activity on the T cells. Antibodies to LAG-3 inhibit suppression both in vitro and in vivo. LAG-3 marks regulatory T cell populations and contributes to their suppressor activity.

Abstract translation: 调节性T细胞（Treg）限制自身免疫，但也可以减弱抗病原体和抗肿瘤免疫的程度。 了解Treg功能的机制和体内Treg的治疗操作需要鉴定Treg选择性受体。 分化为效应物/记忆或调节表型的抗原特异性CD4 + T细胞的基因表达阵列的比较分析揭示了LAG-3（CD223），一种结合MHC II类的CD4相关分子的Treg选择性表达。 CD4 + T细胞上的LAG-3表达与细胞的体外抑制活性相关，LAG-3在CD4T细胞上的异位表达赋予T细胞抑制活性。 LAG-3的抗体在体外和体内均抑制抑制。 LAG-3标记调节性T细胞群体并有助于其抑制活性。

公开(公告)号：WO0183750A9

公开(公告)日：2003-07-03

申请号：PCT/US0113430

申请日：2001-04-27

Applicant: UNIV JOHNS HOPKINS ,  PARDOLL DREW M ,  TSUCHIYA HARUO ,  GORSKI KEVIN S ,  TSENG SU-YI

Inventor： PARDOLL DREW M ,  TSUCHIYA HARUO ,  GORSKI KEVIN S ,  TSENG SU-YI

IPC: C12N15/09 ,  A61K35/14 ,  A61K35/76 ,  A61K38/00 ,  A61K39/39 ,  A61K39/395 ,  A61K48/00 ,  A61P35/00 ,  A61P37/04 ,  A61P37/06 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C07K19/00 ,  C12N5/10 ,  C12N15/12 ,  C12P21/08 ,  A61K38/17 ,  A61K39/00 ,  C12N15/62

CPC classification number: A61K39/39558 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/5152 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61K2039/55516 ,  A61K2039/57 ,  C07K14/70532 ,  C07K16/2827 ,  C07K2319/00 ,  C07K2319/30

Abstract: A costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.

Abstract translation: 作为B7家族成员的共刺激蛋白分子B7-DC被描述为编码该DNA的DNA和包含该DNA的表达载体。 B7-DC蛋白，片段，融合多肽/蛋白质和其他功能衍生物，以及表达B7-DC的转化细胞可用于疫苗组合物和方法。 公开了用于诱导可被用于抗肿瘤和抗病毒免疫的有效的T细胞介导的应答的组合物和方法。

公开(公告)号：WO2010115092A3

公开(公告)日：2010-10-07

申请号：PCT/US2010/029767

申请日：2010-04-02

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  SEARS, Cynthia, L. ,  PARDOLL, Drew, M. ,  WU, Shaoguang ,  HOUSSEAU, Franck

Inventor： SEARS, Cynthia, L. ,  PARDOLL, Drew, M. ,  WU, Shaoguang ,  HOUSSEAU, Franck

IPC: C12Q1/68 ,  G01N33/574 ,  G01N33/68 ,  A61K39/395 ,  A61P35/00 ,  G01N33/15

Abstract: The invention provides compositions and methods for useful for the diagnosis of inflammatory bowel disease, ETBF-induced colitis, colonic hyperplasia and/or colon carcinogenesis in a subject in biological samples (e.g., stool, urine, blood, serum, tissue). The invention further provides compositions and methods for the treatment or prevention of colitis, colon cancer, or inflammatory bowel disease (e.g., Crohn's disease).

公开(公告)号：WO2010115092A2

公开(公告)日：2010-10-07

申请号：PCT/US2010029767

申请日：2010-04-02

Applicant: UNIV JOHNS HOPKINS ,  SEARS CYNTHIA L ,  PARDOLL DREW M ,  WU SHAOGUANG ,  HOUSSEAU FRANCK

Inventor： SEARS CYNTHIA L ,  PARDOLL DREW M ,  WU SHAOGUANG ,  HOUSSEAU FRANCK

IPC: C12Q1/68 ,  A61K39/395 ,  A61P35/00 ,  G01N33/15 ,  G01N33/574 ,  G01N33/68

CPC classification number: G01N33/57419 ,  C07K16/1203 ,  C07K16/244 ,  C07K16/2866 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/56916 ,  G01N2469/20 ,  G01N2500/04 ,  G01N2800/065 ,  Y10T436/143333

Abstract: The invention provides compositions and methods for useful for the diagnosis of inflammatory bowel disease, ETBF-induced colitis, colonic hyperplasia and/or colon carcinogenesis in a subject in biological samples (e.g., stool, urine, blood, serum, tissue). The invention further provides compositions and methods for the treatment or prevention of colitis, colon cancer, or inflammatory bowel disease (e.g., Crohn's disease).

Abstract translation: 本发明提供了用于诊断生物样品（例如，粪便，尿液，血液，血清，组织）中受试者的炎性肠病，ETBF诱导的结肠炎，结肠增生和/或结肠癌发生的组合物和方法。 本发明还提供了用于治疗或预防结肠炎，结肠癌或炎性肠病（例如克罗恩病）的组合物和方法。

公开(公告)号：WO2006065894A2

公开(公告)日：2006-06-22

申请号：PCT/US2005/045225

申请日：2005-12-14

Applicant: UNIVERSITY OF SOUTH FLORIDA ,  THE JOHNS HOPKINS UNIVERSITY ,  YU, Hua, E. ,  JOVE, Richard ,  KORTYLEWSKI, Marcin ,  PARDOLL, Drew, M.

Inventor： YU, Hua, E. ,  JOVE, Richard ,  KORTYLEWSKI, Marcin ,  PARDOLL, Drew, M.

IPC: A61K48/00 ,  A61K33/24 ,  A61K31/28 ,  A61K31/7072 ,  A61K31/7076

CPC classification number: A61K31/28 ,  A61K31/7072 ,  A61K31/7076 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods of enhancing antitumor activity of an immune cell comprising contacting the immune cell with a Stat3 inhibitor are described. Also described are methods of killing a tumor cell or inhibiting tumor growth in a subject comprising an immune cell of the subject with a Stat3 inhibitor.

Abstract translation: 描述了增强免疫细胞的抗肿瘤活性的方法，包括使免疫细胞与Stat3抑制剂接触。 还描述了用Stat3抑制剂杀死肿瘤细胞或抑制受试者包含受试者的免疫细胞的肿瘤生长的方法。

公开(公告)号：WO02074345A3

公开(公告)日：2002-11-28

申请号：PCT/US0208411

申请日：2002-03-18

Applicant: UNIV JOHNS HOPKINS MED ,  PARDOLL DREW M ,  CHENG LINZHAO ,  CUI YAN ,  CIVIN CURT I ,  WHARTENBY KATHERINE

Inventor： PARDOLL DREW M ,  CHENG LINZHAO ,  CUI YAN ,  CIVIN CURT I ,  WHARTENBY KATHERINE

IPC: A01K67/027 ,  A61K35/12 ,  A61K39/00 ,  C12N5/0789 ,  A61K48/00 ,  C12N15/00 ,  C12N15/63 ,  C12N15/85

CPC classification number: A61K39/00 ,  A01K67/0271 ,  A61K39/0008 ,  A61K2035/124 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/57 ,  C12N5/0647 ,  C12N2510/02 ,  C12N2799/027 ,  C12N2830/008

Abstract: The invention provides methods and compositions for the modulation of systemic immune responses by transplantation of hematopoietic stem cells transduced with genes encoding antigens and antigen presenting cell regulatory molecules. The invention includes bi-cistronic lentiviral expression vectors adapted for antigen expression in antigen presenting cells for use in DNA vaccines directed against pathogens and tumor antigens as well as for the treatment of autoimmune disease and for the establishment of antigen tolerance.

Abstract translation: 本发明提供用于通过移植用编码抗原和抗原呈递细胞调节分子的基因转导的造血干细胞来调节全身免疫应答的方法和组合物。 本发明包括适于在抗原呈递细胞中抗原表达的双顺反子慢病毒表达载体，用于针对病原体和肿瘤抗原的DNA疫苗，以及用于治疗自身免疫疾病和建立抗原耐受性。

公开(公告)号：WO2012177624A3

公开(公告)日：2013-04-25

申请号：PCT/US2012043124

申请日：2012-06-19

Applicant: UNIV JOHNS HOPKINS ,  ZENG JING ,  DRAKE CHARLES GEORGE ,  PARDOLL DREW M ,  LIM MICHAEL

Inventor： ZENG JING ,  DRAKE CHARLES GEORGE ,  PARDOLL DREW M ,  LIM MICHAEL

IPC: A61K39/395 ,  A61K51/10 ,  A61P35/00

CPC classification number: A61N5/1001 ,  A61K39/39558 ,  A61K41/00 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  A61N5/1042 ,  C07K16/24 ,  C07K16/2818 ,  C07K16/2878

Abstract: An approach combining immune-based therapies with focused radiation, including stereotactic radiation, to treat cancers is disclosed. The use of focused radiation primes the immune system in a similar manner to vaccines to augment immune-based therapies and can counteract the suppressive effects of a tumor. The combination of focused radiation and immune-based therapies, including administration of at least one immunotherapeutic agent, improves survival compared to each therapy alone and can, in some cases, lead to a durable cure. Accordingly, focused radiation can be an adjuvant for immune-based therapies for treating cancers.

Abstract translation: 公开了一种将基于免疫的疗法与聚焦辐射（包括立体定向辐射）结合治疗癌症的方法。 使用聚焦辐射以与疫苗相似的方式对免疫系统进行补充，以增强基于免疫的疗法，并可抵消肿瘤的抑制作用。 聚焦辐射和基于免疫的疗法的组合，包括施用至少一种免疫治疗剂，与单独的每种治疗相比，改善了存活，并且在一些情况下可以导致持久的治愈。 因此，聚焦辐射可以是用于治疗癌症的基于免疫的疗法的佐剂。