PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE
    5.
    发明申请
    PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE 审中-公开
    制备锕系元素的方法

    公开(公告)号:WO2007020527A2

    公开(公告)日:2007-02-22

    申请号:PCT/IB2006002247

    申请日:2006-08-18

    CPC classification number: C07D333/38

    Abstract: A process for the preparation of strontium ranelate or a hydrate thereof is provided comprising (a) reacting a tetraester compound of Formula II: wherein R, R 1 , R 2 , and R 3 are independently a linear or branched C 1 -C 6 alkyl group or a substituted or unsubstituted C 3 -C 12 cyclic group, in the presence of a lithium base and in a solvent with an inorganic acid salt of strontium.

    Abstract translation: 提供了制备雷奈酸锶或其水合物的方法,其包括(a)使式II的四酯化合物:其中R 1,R 2,R 2和/ R 3独立地是直链或支链C 1 -C 6烷基或取代或未取代的C 3 -C 6烷基, -C 12 - 环基,在锂碱存在下,在溶剂中与锶的无机酸盐反应。

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