公开(公告)号：WO2007110734A1

公开(公告)日：2007-10-04

申请号：PCT/IB2007/000737

申请日：2007-03-23

Applicant: GLENMARK PHARMACEUTICALS LIMITED ,  CRASTO, Anthony, Melvin ,  JOSHI, Narendra, Shriram ,  PRADHAN, Nitin, Sharad, Chandra

Inventor： CRASTO, Anthony, Melvin ,  JOSHI, Narendra, Shriram ,  PRADHAN, Nitin, Sharad, Chandra

IPC: C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: The present invention provides novel intermediates of tadalafil and processes for their preparation. The present invention also provides for the preparation of tadalafil or a pharmaceutically acceptable salt or solvate thereof using the intermediates.

Abstract translation: 本发明提供了他达拉非的新型中间体及其制备方法。 本发明还提供了使用中间体制备他达拉非或其药学上可接受的盐或溶剂合物。

公开(公告)号：WO2006090268A3

公开(公告)日：2006-10-26

申请号：PCT/IB2006000431

申请日：2006-02-28

Applicant: GLENMARK PHARMACEUTICALS LTD ,  JOSHI NARENDRA SHRIRAM ,  RAMAM BUDDHAVARAPU PATTABHI ,  RAO KODALI ESWARA ,  BHIRUD SHEKHAR BHASKAR ,  PRADHAN NITIN S

Inventor： JOSHI NARENDRA SHRIRAM ,  RAMAM BUDDHAVARAPU PATTABHI ,  RAO KODALI ESWARA ,  BHIRUD SHEKHAR BHASKAR ,  PRADHAN NITIN S

IPC: C07D405/12 ,  A61K31/505

CPC classification number: C07D405/12

Abstract: The present invention provides novel crystalline forms of a.lfuzosin and alfuzosin hydrochloride and processes for their preparation. Also provided are pharmaceutical compositions containing the new crystalline forms.

Abstract translation: 本发明提供了福佐沙星和盐酸阿夫唑嗪的新型结晶形式及其制备方法。 还提供含有新结晶形式的药物组合物。

公开(公告)号：WO2008015563A3

公开(公告)日：2008-04-03

申请号：PCT/IB2007002242

申请日：2007-08-03

Applicant: GLENMARK PHARMACEUTICALS LTD ,  JOSHI NARENDRA SHRIRAM ,  KHILE ANIL SHAHAJI ,  KAJALE YOGESH BABURAO

Inventor： JOSHI NARENDRA SHRIRAM ,  KHILE ANIL SHAHAJI ,  KAJALE YOGESH BABURAO

IPC: C07D239/42 ,  A61K31/505 ,  A61P3/06

CPC classification number: C07D239/42

Abstract: Novel salts of rosuvastatin and processes for their preparation are disclosed. Pharmaceutical compositions comprising a therapeutically effective amount of one or more salts of rosuvastatin selected from the group consisting of a barium salt, strontium salt, zinc salt, cesium salt, cadmium salt and mixtures thereof are also disclosed.

Abstract translation: 公开了瑞舒伐他汀的新型盐及其制备方法。 还公开了包含治疗有效量的一种或多种选自钡盐，锶盐，锌盐，铯盐，镉盐及其混合物的瑞舒伐他汀盐的药物组合物。

公开(公告)号：WO2007083188A3

公开(公告)日：2007-10-04

申请号：PCT/IB2006003801

申请日：2006-12-29

Applicant: GLENMARK PHARMACEUTICALS LTD ,  PILLAI BIJU KUMAR GOPINATHEN ,  ARJUNAN SANKAR ,  PRADHAN NITIN SHARAD CHANDRA ,  JOSHI NARENDRA SHRIRAM

Inventor： PILLAI BIJU KUMAR GOPINATHEN ,  ARJUNAN SANKAR ,  PRADHAN NITIN SHARAD CHANDRA ,  JOSHI NARENDRA SHRIRAM

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: A substantially pure dextrorotatory isomer of zopiclone or a pharmaceutically acceptable salt thereof and crystalline forms thereof are provided. Also provided is a process for its preparation and pharmaceutical compositions containing same.

Abstract translation: 提供了佐匹克隆或其药学上可接受的盐及其结晶形式的基本上纯的右旋异构体。 还提供了其制备方法和含有其的药物组合物。

公开(公告)号：WO2008015563A2

公开(公告)日：2008-02-07

申请号：PCT/IB2007/002242

申请日：2007-08-03

Applicant: GLENMARK PHARMACEUTICALS LIMITED ,  JOSHI, Narendra Shriram ,  KHILE, Anil Shahaji ,  KAJALE, Yogesh Baburao

Inventor： JOSHI, Narendra Shriram ,  KHILE, Anil Shahaji ,  KAJALE, Yogesh Baburao

IPC: C07D239/42 ,  A61K31/505 ,  A61P3/06

CPC classification number: C07D239/42

Abstract: Novel salts of rosuvastatin and processes for their preparation are disclosed. Pharmaceutical compositions comprising a therapeutically effective amount of one or more salts of rosuvastatin selected from the group consisting of a barium salt, strontium salt, zinc salt, cesium salt, cadmium salt and mixtures thereof are also disclosed.

Abstract translation: 公开了瑞舒伐他汀的新盐及其制备方法。 还公开了包含治疗有效量的选自钡盐，锶盐，锌盐，铯盐，镉盐及其混合物的罗苏伐他汀的一种或多种盐的药物组合物。

公开(公告)号：WO2008059519A3

公开(公告)日：2009-10-15

申请号：PCT/IN2007000441

申请日：2007-09-24

Applicant: GLENMARK PHARMACEUTICALS LTD ,  JOSHI NARENDRA SHRIRAM ,  KHILE ANIL SHAHAJI ,  KAJALE YOGESH BABURAO ,  KAMBLE HEMANT HARISHCHANDRA

Inventor： JOSHI NARENDRA SHRIRAM ,  KHILE ANIL SHAHAJI ,  KAJALE YOGESH BABURAO ,  KAMBLE HEMANT HARISHCHANDRA

IPC: C07D239/42

CPC classification number: C07D239/42 ,  C07D319/06

Abstract: The present invention provides a process for the preparation of the rosuvastatin intermediates and their conversion to rosuvastatin or its pharmaceutically acceptable salts thereof.

Abstract translation: 本发明提供了一种制备瑞舒伐他汀中间体及其转化为瑞舒伐他汀或其药学上可接受的盐的方法。

公开(公告)号：WO2007085933A3

公开(公告)日：2009-05-07

申请号：PCT/IB2007000150

申请日：2007-01-23

Applicant: GLENMARK PHARMACEUTICALS LTD ,  JOSHI NARENDRA SHRIRAM ,  PRADHAN NITIN SHARAD CHANDRA

Inventor： JOSHI NARENDRA SHRIRAM ,  PRADHAN NITIN SHARAD CHANDRA

IPC: A61K31/40 ,  C07D209/00 ,  C07D209/42

CPC classification number: C07D251/34 ,  C07K5/06026

Abstract: A compound N-[l-(S)-ethoxycarbonyl-l-butyl]-(S)-alanine-DMT complex of Formula (II) is provided. Also provided is a process for the preparation of N-[l-(S)-ethoxycarbonyl-l-butyl]-(S)- alanine-DMT complex and its use in preparing perindopril or a pharmaceutically acceptable salt thereof.

Abstract translation: 提供式（II）的化合物N- [1-（S） - 乙氧基羰基-1-丁基] - （S） - 丙氨酸-DMT络合物。 还提供了制备N- [1-（S） - 乙氧基羰基-1-丁基] - （S） - 丙氨酸-DMT复合物的方法及其在制备培哚普罗或其药学上可接受的盐中的用途。

公开(公告)号：WO2009019721A2

公开(公告)日：2009-02-12

申请号：PCT/IN2008/000496

申请日：2008-08-08

Applicant: DABUR PHARMA LIMITED ,  JOSHI, Narendra Shriram ,  AGGARWAL, Pawan ,  HIRPARA, Vitthalbhai Ketan ,  JAGGI, Manu ,  SINGH, Anu T. ,  AWASTHI, Anshumali ,  VERMA, Ritu

Inventor： JOSHI, Narendra Shriram ,  AGGARWAL, Pawan ,  HIRPARA, Vitthalbhai Ketan ,  JAGGI, Manu ,  SINGH, Anu T. ,  AWASTHI, Anshumali ,  VERMA, Ritu

CPC classification number: C07D311/30

Abstract: The present invention provides novel Quercetin derivatives of formula (I) and pharmaceutically acceptable salts, hydrates, and solvates thereof, Formula (I): wherein R 1 is hydrogen, benzyl or substituted benzyl; R 2 is hydrogen, benzyl or substituted benzyl, linear or branched (C 1 -C 6 ) alkyl, substituted alkyl, aryl, substituted aryl, heterqcyele,and (Substituted heterocycle, useful for treatment of various disorders including cancer, multi-drug resistant cancers, viral infections etc. The invention also provides a process for the preparation of compounds of formula (I) and pharmaceutical compositions comprising the same.

Abstract translation: 本发明提供式（I）的新型槲皮素衍生物及其药学上可接受的盐，水合物和溶剂合物，式（I）：其中R 1是氢，苄基或取代的苄基; R 2是氢，苄基或取代的苄基，直链或支链（C 1 -C 6）烷基，取代的烷基，芳基，取代的芳基，异胞核和（取代的杂环，可用于治疗各种疾病，包括癌症，多药耐药性癌症，病毒 感染等。本发明还提供了制备式（I）化合物的方法和包含其的药物组合物。

公开(公告)号：WO2007083188A2

公开(公告)日：2007-07-26

申请号：PCT/IB2006/003801

申请日：2006-12-29

Applicant: GLENMARK PHARMACEUTICALS LIMITED ,  PILLAI, Biju, Kumar, Gopinathen ,  ARJUNAN, Sankar ,  PRADHAN, Nitin, Sharad, Chandra ,  JOSHI, Narendra, Shriram

Inventor： PILLAI, Biju, Kumar, Gopinathen ,  ARJUNAN, Sankar ,  PRADHAN, Nitin, Sharad, Chandra ,  JOSHI, Narendra, Shriram

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: A substantially pure dextrorotatory isomer of zopiclone or a pharmaceutically acceptable salt thereof and crystalline forms thereof are provided. Also provided is a process for its preparation and pharmaceutical compositions containing same.

Abstract translation: 提供了佐匹克隆的基本上纯的右旋异构体或其药学上可接受的盐及其晶体形式。 还提供了其制备方法和含有它的药物组合物。

公开(公告)号：WO2006136916A3

公开(公告)日：2007-05-18

申请号：PCT/IB2006001663

申请日：2006-06-20

Applicant: GLENMARK PHARMACEUTICALS LTD ,  JOSHI NARENDRA SHRIRAM ,  RAO KODALI ESWARA ,  PRADHAN NITIN S

Inventor： JOSHI NARENDRA SHRIRAM ,  RAO KODALI ESWARA ,  PRADHAN NITIN S

IPC: A61K9/14 ,  A61K31/4184

CPC classification number: A61K31/4184 ,  A61K9/1688

Abstract: The present invention provides micronized particles of substantially pure telmisartan or a pharmaceutically acceptable salt, ester or derivative thereof. Also provided are pharmaceutical compositions containing the micronized particles of substantially pure telmisartan or a pharmaceutically acceptable salt, ester or derivative thereof.

Abstract translation: 本发明提供基本上纯的替米沙坦或其药学上可接受的盐，酯或衍生物的微粉化颗粒。 还提供了含有基本上纯的替米沙坦或其药学上可接受的盐，酯或衍生物的微粉化颗粒的药物组合物。