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1.发明申请COMPOSITIONS COMPRISING INDOLEAMINE 2,3- DIOXYGENASE-2 AND COENZYME Q INHIBITORS AND METHODS OF USE THEREOF 审中-公开包含吲哚胺2,3-二氧杂环己烷-2和聚苯乙烯Q抑制剂的组合物及其使用方法
公开(公告)号：WO2009003164A1
公开(公告)日：2008-12-31
申请号：PCT/US2008/068557
申请日：2008-06-27
Applicant: LANKENAU INSTITUTE FOR MEDICAL RESEARCH DEVELOPMENT, INC. , PRENDERGAST, George, C. , METZ, Richard
Inventor： PRENDERGAST, George, C. , METZ, Richard
CPC classification number: A61K31/44 , A61K31/122 , A61K45/06 , A61K2300/00
Abstract: Compositions comprising coenzyme Q and ID02 inhibitors and methods of use thereof are provided.
Abstract translation: 提供了包含辅酶Q和ID02抑制剂的组合物及其使用方法。
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公开(公告)号：WO2008143668A2
公开(公告)日：2008-11-27
申请号：PCT/US2007/069271
申请日：2007-05-18
Inventor： PRENDERGAST, George, C. , METZ, Richard
IPC: A01K67/027
CPC classification number: C12N9/0069 , A01K67/0276 , C07K2319/21 , C07K2319/40 , C12N2830/006 , C12Q1/26
Abstract: The nucleotide and amino acid sequences of indoleamine 2, 3-dioxygenase-2 (ID02) and methods of use thereof are provided.
Abstract translation: 提供了吲哚胺2,3-双加氧酶-2（ID02）的核苷酸和氨基酸序列及其使用方法。
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公开(公告)号：WO2007050963A1
公开(公告)日：2007-05-03
申请号：PCT/US2006/042137
申请日：2006-10-27
Applicant: LANKENAU INSTITUTE FOR MEDICAL RESEARCH , DUHADAWAY, James, B. , PRENDERGAST, George, C. , MALACHOWSKI, William, P. , MULLER, Alexander, J.
Inventor： DUHADAWAY, James, B. , PRENDERGAST, George, C. , MALACHOWSKI, William, P. , MULLER, Alexander, J.
IPC: C07D209/20
CPC classification number: C07D209/10 , C07C333/20 , C07C333/22 , C07C2602/08 , C07C2603/74 , C07D333/54 , C07D401/12 , C07D417/06
Abstract: Novel indoleamine 2 , 3-di oxygenase (IDO) inhibitors, compositions comprising the same, and methods of use thereof are disclosed.
Abstract translation: 公开了新的吲哚胺2,3-二加氧酶（IDO）抑制剂，包含其的组合物及其使用方法。
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公开(公告)号：WO2004093871A1
公开(公告)日：2004-11-04
申请号：PCT/US2004/005155
申请日：2004-02-20
Applicant: LANKENAU INSTITUTE FOR MEDICAL RESEARCH , PRENDERGAST, George, C. , MULLER, Alexander, J. , DUHADAWAY, James, B. , MALACHOWSKI, William
Inventor： PRENDERGAST, George, C. , MULLER, Alexander, J. , DUHADAWAY, James, B. , MALACHOWSKI, William
IPC: A61K31/405
CPC classification number: C07D403/06 , A61K31/353 , A61K31/405 , A61K31/4745 , A61K38/04 , A61K45/06 , C07D209/14 , C07D403/12 , C07D403/14 , C07D471/04 , C07D513/04 , C07D517/04 , A61K2300/00
Abstract: Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed.
Abstract translation: 公开了用于治疗恶性和慢性病毒感染的组合物和方法。
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5.发明申请METHODS AND COMPOSITIONS FOR THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES 审中-公开治疗自身免疫性和炎性疾病的方法和组合物
公开(公告)号：WO2013023059A2
公开(公告)日：2013-02-14
申请号：PCT/US2012050146
申请日：2012-08-09
Applicant: LANKENAU INST MEDICAL RES , LAURY-KLEINTOP LISA , MANDIK-NAYAK LAURA , PRENDERGAST GEORGE C , DUHADAWAY JAMES
Inventor： LAURY-KLEINTOP LISA , MANDIK-NAYAK LAURA , PRENDERGAST GEORGE C , DUHADAWAY JAMES
IPC: A61K39/395
CPC classification number: C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/00
Abstract: Compositions and methods for the treatment of autoimmune and inflammatory diseases are disclosed.
Abstract translation: 公开了用于治疗自身免疫疾病和炎症疾病的组合物和方法。
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Patent Agency Ranking
公开(公告)号：WO2007075672A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/048411
申请日：2006-12-20
Applicant: LANKENAU INSTITUTE FOR MEDICAL RESEARCH , WALLON, U., Margaretha , PRENDERGAST, George, C. , KNUDSEN, Karen, A.
Inventor： WALLON, U., Margaretha , PRENDERGAST, George, C. , KNUDSEN, Karen, A.
IPC: G01N33/574
CPC classification number: G01N33/574 , G01N33/57415 , G01N33/57484
Abstract: Methods, kits, and compositions for diagnosing, assessing the prognosis of, or monitoring the progression of cancer, particularly breast cancer, in a subject are provided.
Abstract translation: 提供了用于诊断，评估患者的癌症，特别是乳腺癌的预后或监测其进展的方法，试剂盒和组合物。
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7.发明申请BRIDGING INTEGRATOR-2 (BIN2) NUCLEIC ACID MOLECULES AND PROTEINS AND USES THEREFOR 审中-公开BRIDGING INTEGRATOR-2（BIN2）核酸分子和蛋白质及其用途
公开(公告)号：WO0116158A3
公开(公告)日：2001-06-07
申请号：PCT/US0023723
申请日：2000-08-30
Applicant: WISTAR INST , PRENDERGAST GEORGE C , GE KAI
Inventor： PRENDERGAST GEORGE C , GE KAI
IPC: A61K38/00 , C07K14/47 , C12P21/06 , C07H21/04 , C07K1/00 , C12N1/20 , C12N5/00 , C12N15/09 , C12N15/63
Abstract: The present invention provides Bin2 sequences and proteins encoded thereby. Also provided are compositions and methods utilizing these sequences and proteins in the diagnosis and treatment of blood disorders, including hepatocarcinoma. Further provided are oligonucleotides derived from sequences encoding Bin2, as well as compositions and methods utilizing same for diagnostic and therapeutic purposes.
Abstract translation: 本发明提供了Bin2序列和由其编码的蛋白质。 还提供了利用这些序列和蛋白质诊断和治疗血液病症（包括肝癌）的组合物和方法。 还提供了源自编码Bin2的序列的寡核苷酸，以及用于诊断和治疗目的的组合物和使用其的方法。
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公开(公告)号：WO2013023059A3
公开(公告)日：2013-02-14
申请号：PCT/US2012/050146
申请日：2012-08-09
Applicant: LANKENAU INSTITUTE FOR MEDICAL RESEARCH , LAURY-KLEINTOP, Lisa , MANDIK-NAYAK, Laura , PRENDERGAST, George, C. , DUHADAWAY, James
Abstract: Compositions and methods for the treatment of autoimmune and inflammatory diseases are disclosed.
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公开(公告)号：WO2008143668A3
公开(公告)日：2009-03-26
申请号：PCT/US2007069271
申请日：2007-05-18
Applicant: LANKENAU INST MEDICAL RES , PRENDERGAST GEORGE C , METZ RICHARD
Inventor： PRENDERGAST GEORGE C , METZ RICHARD
IPC: C07K2/00
CPC classification number: C12N9/0069 , A01K67/0276 , C07K2319/21 , C07K2319/40 , C12N2830/006 , C12Q1/26
Abstract: The nucleotide and amino acid sequences of indoleamine 2, 3-dioxygenase-2 (ID02) and methods of use thereof are provided.
Abstract translation: 提供了吲哚胺2,3-双加氧酶-2（ID02）的核苷酸和氨基酸序列及其使用方法。
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公开(公告)号：WO2004094409A1
公开(公告)日：2004-11-04
申请号：PCT/US2004/005154
申请日：2004-02-20
Applicant: LANKENAU INSTITUTE FOR MEDICAL RESEARCH , PRENDERGAST, George, C. , MULLER, Alexander, J. , DUHADAWAY, James, B. , MALACHOWSKI, William
Inventor： PRENDERGAST, George, C. , MULLER, Alexander, J. , DUHADAWAY, James, B. , MALACHOWSKI, William
IPC: C07D403/06
CPC classification number: C07D403/06 , A61K31/353 , A61K31/405 , A61K31/4745 , A61K38/04 , A61K45/06 , C07D209/14 , C07D403/12 , C07D403/14 , C07D471/04 , C07D513/04 , C07D517/04 , A61K2300/00
Abstract: Compounds, compositions and methods for the treatment of malignancy are disclosed.
Abstract translation: 公开了用于治疗恶性肿瘤的化合物，组合物和方法。
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