公开(公告)号：WO2006037660A3

公开(公告)日：2006-08-03

申请号：PCT/EP2005010885

申请日：2005-10-10

Applicant: DEUTSCHES KREBSFORSCH ,  WOLF STEPHAN ,  JOSS STEFAN ,  MERTENS DANIEL ,  PSCHERER ARMIN ,  LICHTER PETER

Inventor： WOLF STEPHAN ,  JOSS STEFAN ,  MERTENS DANIEL ,  PSCHERER ARMIN ,  LICHTER PETER

IPC: G01N33/48 ,  A61K39/395

CPC classification number: G01N33/57426 ,  G01N2333/715 ,  G01N2500/00

Abstract: Described are methods and compounds for diagnosis and therapy of subsets of cell proliferative disorders which are characterized by resistance to TRAIL induced apoptosis. Examples of such diseases are B-cell chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL) and prostate cancer. Furthermore, methods for identifying drugs which are suitable for treatment of such diseases are described.

Abstract translation: 描述了用于诊断和治疗以TRAIL诱导的细胞凋亡抗性为特征的细胞增殖性病症亚群的方法和化合物。 这些疾病的例子是B细胞慢性淋巴细胞性白血病（CLL），套细胞淋巴瘤（MCL）和前列腺癌。 此外，描述了鉴定适合于治疗这些疾病的药物的方法。

公开(公告)号：WO2006037660A2

公开(公告)日：2006-04-13

申请号：PCT/EP2005/010885

申请日：2005-10-10

Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENFTLICHEN RECHTS ,  WOLF, Stephan ,  JOSS, Stefan ,  MERTENS, Daniel ,  PSCHERER, Armin ,  LICHTER, Peter

Inventor： WOLF, Stephan ,  JOSS, Stefan ,  MERTENS, Daniel ,  PSCHERER, Armin ,  LICHTER, Peter

CPC classification number: G01N33/57426 ,  G01N2333/715 ,  G01N2500/00

Abstract: Described are methods and compounds for diagnosis and therapy of subsets of cell proliferative disorders which are characterized by resistance to TRAIL induced apoptosis. Examples of such diseases are B-cell chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL) and prostate cancer. Furthermore, methods for identifying drugs which are suitable for treatment of such diseases are described.

Abstract translation: 描述了用于诊断和治疗细胞增殖性病症亚群的方法和化合物，其特征在于对TRAIL诱导的凋亡的抗性。 这些疾病的实例是B细胞慢性淋巴细胞白血病（CLL），套细胞淋巴瘤（MCL）和前列腺癌。 此外，描述了用于鉴定适合于治疗这些疾病的药物的方法。