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公开(公告)号：WO2004014311A3
公开(公告)日：2004-04-29
申请号：PCT/US0325004
申请日：2003-08-07
Applicant: UNIV YALE , BIOGEN IDEC INC , LEE DANIEL H S , PEPINSKY R BLAKE , LI WEIWEI , RABACCHI SYLVIA A , RELTON JANE K , WORLEY DANE S , STRITTMATTER STEPHEN M , SAH DINAH Y W
Inventor： LEE DANIEL H S , PEPINSKY R BLAKE , LI WEIWEI , RABACCHI SYLVIA A , RELTON JANE K , WORLEY DANE S , STRITTMATTER STEPHEN M , SAH DINAH Y W
IPC: C12N15/09 , A61K39/395 , A61K48/00 , A61P43/00 , C07H21/04 , C07K20060101 , C07K5/00 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/11 , C12N15/85 , C12P21/02 , C12P21/08
CPC classification number: C07K14/705 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2319/00 , C07K2319/30 , Y10S530/809
Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigenbinding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same.
Abstract translation: 公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码它们的核酸。 还公开了包含这种Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码它们的核酸的组合物以及制备和使用该组合物的方法。
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公开(公告)号：WO2004014311A2
公开(公告)日：2004-02-19
申请号：PCT/US2003/025004
申请日：2003-08-07
Applicant: YALE UNIVERSITY , BIOGEN, INC. , LEE, Daniel, H., S. , PEPINSKY, R., Blake , LI, Weiwei , RABACCHI, Sylvia, A. , RELTON, Jane, K. , WORLEY, Dane, S. , STRITTMATTER, Stephen, M. , SAH, Dinah, Y., W.
Inventor： LEE, Daniel, H., S. , PEPINSKY, R., Blake , LI, Weiwei , RABACCHI, Sylvia, A. , RELTON, Jane, K. , WORLEY, Dane, S. , STRITTMATTER, Stephen, M. , SAH, Dinah, Y., W.
IPC: A61K
CPC classification number: C07K14/705 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2319/00 , C07K2319/30 , Y10S530/809
Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigenbinding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same.
Abstract translation: 公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码其的核酸。 还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白以及编码其的核酸的制备和使用方法。
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3.发明申请USE OF NOGO RECEPTOR-1 (NGR1) ANTAGONISTS FOR PROMOTING OLIGODENDROCYTE SURVIVAL 审中-公开NOGO受体-1（NGR1）拮抗剂用于促进OLIGODENDROCYTE SURVIVAL的使用
公开(公告)号：WO2007133746A2
公开(公告)日：2007-11-22
申请号：PCT/US2007011557
申请日：2007-05-15
Applicant: BIOGEN IDEC INC , RELTON JANE K , LI MINGWEI , JI BENXIU
Inventor： RELTON JANE K , LI MINGWEI , JI BENXIU
IPC: A61M5/32
CPC classification number: C07K14/705 , A61K38/00
Abstract: The invention provides methods of treating diseases, disorsers or injuries involving oligodendrocyte death, demyelination and dysmyelination, including spinal cord injury, by the administration of an NgR1 antagonist.
Abstract translation: 本发明提供了通过施用NgR1拮抗剂治疗涉及少突胶质细胞死亡，脱髓鞘和脱髓鞘疾病（包括脊髓损伤）的疾病，脱发剂或损伤的方法。
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公开(公告)号：WO2007089601A2
公开(公告)日：2007-08-09
申请号：PCT/US2007002199
申请日：2007-01-26
Applicant: BIOGEN IDEC INC , LEE DANIEL H S , WEN DINGYI , PEPINSKY BLAKE R , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
Inventor： LEE DANIEL H S , WEN DINGYI , PEPINSKY BLAKE R , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
IPC: C07K7/64 , C12N15/113
CPC classification number: C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
Abstract translation: 公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码其的核酸。 还公开了Nogo受体拮抗剂多核苷酸。 还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白，编码相同的拮抗剂多核苷酸的核酸和制备和使用的组合物。
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公开(公告)号：WO2007089601A8
公开(公告)日：2008-10-02
申请号：PCT/US2007002199
申请日：2007-01-26
Applicant: BIOGEN IDEC INC , LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
Inventor： LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
IPC: C07K7/64 , C12N15/113
CPC classification number: C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
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Patent Agency Ranking
公开(公告)号：WO2007089601A3
公开(公告)日：2007-08-09
申请号：PCT/US2007/002199
申请日：2007-01-26
Applicant: BIOGEN IDEC MA INC. , LEE, Daniel, H.S. , WEN, Dingyi , PEPINSKY, R., Blake , RELTON, Jane, K. , WANG, Xinzhong , LUGOVSKOY, Alexey , MEIER, Werner , GARBER, Ellen, A. , SILVIAN, Laura , WEINREB, Paul, H.
Inventor： LEE, Daniel, H.S. , WEN, Dingyi , PEPINSKY, R., Blake , RELTON, Jane, K. , WANG, Xinzhong , LUGOVSKOY, Alexey , MEIER, Werner , GARBER, Ellen, A. , SILVIAN, Laura , WEINREB, Paul, H.
IPC: A61K39/395 , A61K38/17 , C07K16/28 , C07K14/705
Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
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7.发明申请TREATMENT OF CONDITIONS INVOLVING DOPAMINERGIC NEURONAL DEGENERATION USING NOGO RECEPTOR ANTAGONISTS 审中-公开使用NOGO受体拮抗剂治疗涉及多巴胺神经元变性的病症
公开(公告)号：WO2005074972A2
公开(公告)日：2005-08-18
申请号：PCT/US2005/002535
申请日：2005-01-28
Applicant: BIOGEN IDEC MA INC. , YALE UNIVERSITY , RELTON, Jane K. , ENGBER, Thomas M. , STRITTMATTER, Stephen M.
Inventor： RELTON, Jane K. , ENGBER, Thomas M. , STRITTMATTER, Stephen M.
IPC: A61K38/17
CPC classification number: A61K38/1787 , C07K14/4703 , C07K16/28
Abstract: The invention provides methods for promoting regeneration or survival of dopaminergic neurons in a mammal displaying signs or symptoms of dopaminergic neuronal degeneration, including a human with Parkinson's disease, using Nogo receptor antagonists.
Abstract translation: 本发明提供使用Nogo受体拮抗剂促进显示多巴胺能神经元变性症状或症状的哺乳动物多巴胺能神经元的再生或存活的方法，包括帕金森病患者。
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8.发明申请SYSTEMIC ADMINISTRATION OF COLONY STIMULATING FACTORS TO TREAT AMYLOID ASSOCIATED DISORDERS 审中-公开系统管理集落刺激因子治疗淀粉样变性相关性疾病
公开(公告)号：WO2008060610A3
公开(公告)日：2008-12-04
申请号：PCT/US2007024055
申请日：2007-11-16
Applicant: BIOGEN IDEC INC , WONG GORDON , RELTON JANE K
Inventor： WONG GORDON , RELTON JANE K
IPC: A61K38/00
CPC classification number: A61K38/193
Abstract: The invention relates a method of treating amyloidosis, diseases and disorders associated with amyloid plaque formation, e.g., Alzheimer's disease by increasing tissue resident macrophage activity in an organ or tissue of an animal requiring treatment by systemic administration of a colony stimulating factor. For example, the activity of bone marrow-derived microglial cells in an organ or tissue can be increased by systemic administration of a colony stimulating factor, particularly macrophage colony stimulating factor, either alone or in combination with additional colony stimulating factors, stem cell factors or other compounds capable of treating amyloidosis.
Abstract translation: 本发明涉及通过增加需要通过系统施用集落刺激因子治疗的动物的器官或组织中的组织驻留巨噬细胞活性来治疗淀粉样变性，与淀粉样斑块形成相关的疾病和病症（例如阿尔茨海默氏病）的方法。 例如，可以通过单独或与其他集落刺激因子，干细胞因子或其组合的系统性施用集落刺激因子，特别是巨噬细胞集落刺激因子来增加器官或组织中骨髓来源的小神经胶质细胞的活性 其他能够治疗淀粉样变性的化合物。
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公开(公告)号：WO2007140249A1
公开(公告)日：2007-12-06
申请号：PCT/US2007/069654
申请日：2007-05-24
Applicant: BIOGEN IDEC MA INC. , RELTON, Jane K. , GARDNER, Humphrey
Inventor： RELTON, Jane K. , GARDNER, Humphrey
CPC classification number: G01N33/6896 , A61K31/00 , A61K38/193 , A61K38/49 , A61K2039/505 , C07K16/2842 , G01N2800/2871 , A61K2300/00
Abstract: Methods and compositions for treating stroke are disclosed.
Abstract translation: 公开了治疗中风的方法和组合物。
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公开(公告)号：WO2007133746A3
公开(公告)日：2007-11-22
申请号：PCT/US2007/011557
申请日：2007-05-15
Applicant: BIOGEN IDEC MA INC. , RELTON, Jane, K. , LI, Mingwei , JI, Benxiu
Inventor： RELTON, Jane, K. , LI, Mingwei , JI, Benxiu
Abstract: The invention provides methods of treating diseases, disorsers or injuries involving oligodendrocyte death, demyelination and dysmyelination, including spinal cord injury, by the administration of an NgR1 antagonist.
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