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公开(公告)号：WO2011031621A8
公开(公告)日：2012-04-19
申请号：PCT/US2010047662
申请日：2010-09-02
Applicant: FMC CORP , GASEROD OLAV , LARSEN CHRISTIAN KLEIN , ANDERSEN PEDER OSCAR
Inventor： GASEROD OLAV , LARSEN CHRISTIAN KLEIN , ANDERSEN PEDER OSCAR
CPC classification number: B01J13/046 , A23K40/30 , A23P10/30 , A61K9/4808 , A61K9/4816 , A61K9/4833 , A61K47/02 , A61K47/36 , B01J13/20 , B01J13/206
Abstract: The invention is directed to a seamless alginate capsule having a film encapsulating a fill material, in which the film comprises alginate, noncrystallizing plasticizer, and glycerol and in which a ratio by weight of noncrystallizing plasticizer to glycerol in the film is between about 1 :1 and about 8:1. The invention is also directed to a method of making the seamless alginate capsules and to capsules made by the method. The capsules have excellent breaking strength and are resistant to oxidation of the fill material.
Abstract translation: 本发明涉及一种无缝藻酸盐胶囊，其具有包封填充材料的薄膜，其中该薄膜包含藻酸盐，非结晶增塑剂和甘油，其中薄膜中非结晶增塑剂与甘油的重量比为约1:1 约8：1。 本发明还涉及制备无缝藻酸盐胶囊和通过该方法制成的胶囊的方法。 胶囊具有优异的断裂强度并且耐填充材料的氧化。
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公开(公告)号：WO2007148197A3
公开(公告)日：2008-03-13
申请号：PCT/IB2007001627
申请日：2007-06-18
Applicant: FMC BIOPOLYMER AS , GASEROD OLAV
Inventor： GASEROD OLAV
IPC: A23L1/308 , A21D2/18 , A23L1/0524 , A23L1/0528 , A23L1/0532 , A23L1/09 , A23L2/52
CPC classification number: A21D2/183 , A23L2/52 , A23L29/231 , A23L29/256 , A23L29/30 , A23L33/25 , A23V2002/00 , A23V2200/3202
Abstract: A gastro-activated dietary fiber comprising an insoluble polysaccharide salt and use of the gastro-activated dietary fiber in ingestible products. The gastro- activated dietary fibers may include salts of biopolymers such as alginates, carrageenans and pectins that are insoluble in water and exhibit minimal or no swelling in water. The water swelling ratio of the gastro-activated dietary fiber may 15 or less. The gastro-activation of the dietary fiber may be induced by exposure to an acidic pH of 3 or less for at least 15 minutes. Ingestible compositions containing the gastro-activated dietary fiber solubilize and provide a viscosity increase in the digestive tract as a result of activation of the dietary fiber by natural excretions of the small intestine which induce gelation of the dietary fiber. Beneficial health effects are potentially obtained by the provision of dietary fiber in this manner, without the usual disadvantages of reduced palatability and poor mouthfeel that are associated with soluble fiber-containing ingestible compositions.
Abstract translation: 包含不溶性多糖盐的胃激活膳食纤维和在可摄取产品中使用胃激活膳食纤维。 胃激活的膳食纤维可以包括生物聚合物的盐，例如藻酸盐，角叉菜胶和果胶，其不溶于水并且在水中表现出最小的或没有溶胀。 胃激素膳食纤维的水溶胀率可以为15以下。 膳食纤维的胃激活可以通过暴露于3或更小的酸性pH至少15分钟来诱导。 含有胃激素膳食纤维的可摄取组合物可增加消化道的粘度增加，这是由于引起膳食纤维凝胶化的小肠的天然排泄而使膳食纤维活化的结果。 通过以这种方式提供膳食纤维可能获得有益的健康影响，而没有与可溶性纤维含有可摄取组合物相关联的适口性差和口感差的通常缺点。
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公开(公告)号：WO2007148197A2
公开(公告)日：2007-12-27
申请号：PCT/IB2007/001627
申请日：2007-06-18
Applicant: FMC BIOPOLYMER AS , GASEROD, Olav
Inventor： GASEROD, Olav
IPC: A23L1/308 , A23L1/09 , A23L1/0524 , A23L1/0528 , A23L1/0532 , A23L2/52 , A21D2/18
CPC classification number: A21D2/183 , A23L2/52 , A23L5/00 , A23L7/00 , A23L29/231 , A23L29/256 , A23L29/30 , A23L33/125 , A23L33/25 , A23V2002/00 , A23V2200/3202
Abstract: A gastro-activated dietary fiber comprising an insoluble polysaccharide salt and use of the gastro-activated dietary fiber in ingestible products. The gastro- activated dietary fibers may include salts of biopolymers such as alginates, carrageenans and pectins that are insoluble in water and exhibit minimal or no swelling in water. The water swelling ratio of the gastro-activated dietary fiber may 15 or less. The gastro-activation of the dietary fiber may be induced by exposure to an acidic pH of 3 or less for at least 15 minutes. Ingestible compositions containing the gastro-activated dietary fiber solubilize and provide a viscosity increase in the digestive tract as a result of activation of the dietary fiber by natural excretions of the small intestine which induce gelation of the dietary fiber. Beneficial health effects are potentially obtained by the provision of dietary fiber in this manner, without the usual disadvantages of reduced palatability and poor mouthfeel that are associated with soluble fiber-containing ingestible compositions.
Abstract translation: 包含不溶性多糖盐的胃激活膳食纤维和在可摄取产品中使用胃激活膳食纤维。 胃激活的膳食纤维可以包括生物聚合物的盐，例如藻酸盐，角叉菜胶和果胶，其不溶于水并且在水中表现出最小的或没有溶胀。 胃激素膳食纤维的水溶胀率可以为15以下。 膳食纤维的胃激活可以通过暴露于3或更小的酸性pH至少15分钟来诱导。 含有胃激素膳食纤维的可摄取组合物可增加消化道的粘度增加，这是由于引起膳食纤维凝胶化的小肠的天然排泄而使膳食纤维活化的结果。 通过以这种方式提供膳食纤维可能获得有益的健康影响，而没有与可溶性纤维含有可摄取组合物相关联的适口性差和口感差的通常缺点。
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公开(公告)号：WO2007103209A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/005436
申请日：2007-03-01
Applicant: FMC BIOPOLYMER AS , FMC CORPORATION , GASEROD, Olav , ANDERSEN, Therese , MELVIK, Jan, Egil , DORNISH, Michael , RILEY, Peter, J.
Inventor： GASEROD, Olav , ANDERSEN, Therese , MELVIK, Jan, Egil , DORNISH, Michael , RILEY, Peter, J.
Abstract: The invention relates to composites comprising a polysaccharide gelled within pores of a foam, methods of preparation, and uses thereof, for example, in biomedical applications such as cell culture media and implants, controlled release delivery systems, food applications, industrial applications, and personal care applications such as cosmetic and oral hygiene. The composites of the present invention are simple to formulate using few steps and are useful for entrapping heat-sensitive components, such as cells, drugs, flavors or fragrances within the polysaccharide gel. In addition, the invention provides for a composite able to gently immobilize fragile components, such as living cells, without exposing such components to shear forces.
Abstract translation: 本发明涉及包含在泡沫的孔内凝胶化的多糖的复合材料，制备方法及其用途，例如在生物医学应用中，例如细胞培养基和植入物，控制释放递送系统，食品应用，工业应用和个人 护理应用如化妆品和口腔卫生。 本发明的复合材料使用几个步骤简单的配制，并且可用于在多糖凝胶内捕获热敏组分如细胞，药物，香料或香料。 此外，本发明提供了一种复合材料，其能够轻柔地固定易碎组分如活细胞，而不会使这些组分暴露于剪切力。
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公开(公告)号：WO2007103186A3
公开(公告)日：2007-09-13
申请号：PCT/US2007/005387
申请日：2007-02-28
Applicant: FMC CORPORATION , ANDERSEN, Peder, Oscar , KOPESKY, Robert , LARSEN, Christian, Klein , GASEROD, Olav , HARVEY, David , TUNG, Sanhuang
Inventor： ANDERSEN, Peder, Oscar , KOPESKY, Robert , LARSEN, Christian, Klein , GASEROD, Olav , HARVEY, David , TUNG, Sanhuang
Abstract: An apparatus for a continuous encapsulation process is provided. The apparatus is a vibrating tubing used alone, in series, or in combination with an encapsulation apparatus, which is used alone or in series. The vibrating tubing is a flat coil, a standing spiral, or a flume. The encapsulation apparatus includes a winding having coils disposed in an aqueous gelling solution. The winding is rotatable about its longitudinal center axis. The winding has adjacently spaced coils forming a plurality of chambers. Objects to be encapsulated are added to the apparatus such that when the winding is rotated, the chambers transport a volume of objects through the length winding in the aqueous gelling solution in a predetermined time.
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Patent Agency Ranking
公开(公告)号：WO2011031617A3
公开(公告)日：2011-07-28
申请号：PCT/US2010047652
申请日：2010-09-02
Applicant: FMC CORP , GASEROD OLAV , LARSEN CHRISTIAN KLEIN , ANDERSEN PEDER OSCAR
Inventor： GASEROD OLAV , LARSEN CHRISTIAN KLEIN , ANDERSEN PEDER OSCAR
CPC classification number: B01J13/046 , A23K40/30 , A23P10/30 , A61K9/4808 , A61K9/4816 , A61K9/4833 , A61K47/02 , A61K47/36 , B01J13/20 , B01J13/206
Abstract: The present invention is directed to a dried seamless capsule comprising an alginate shell membrane encapsulating fill material, wherein: (i) said alginate shell membrane comprises a polyvalent metal ion alginate having: (a) an average M content of from 50%-62% by weight based on the weight of the M and G content, and (b) a viscosity of 35 to 80 cps when measured as a monovalent metal ion alginate in a 3.5% water solution at 20 ?C using a Brookf?eld LV viscometer at 60 rpm and spindle #1; (ii) said alginate shell membrane encapsulates an oil present in an amount of at least 50% by weight of said fill material; (iii) said dried seamless capsule has a disintegration time of less than 12 minutes in an intestinal buffer after pretreatment for 20 minutes in a solution of 0.1 M NaCl and HCl, pH of 3, at 37 ?C; and (iv) said dried seamless capsule has a dry break force strength of at least 7kg. The present invention is also directed to methods of making and using such dried seamless capsules.
Abstract translation: 本发明涉及一种干燥无缝胶囊，其包含包封填充材料的藻酸盐壳膜，其中：（i）所述藻酸盐壳膜包含多价金属离子藻酸盐，其具有：（a）平均M含量为50％-62％ 基于M和G含量的重量计，和（b）在20℃下在3.5％水溶液中使用布鲁克菲尔德LV粘度计测量为一价金属离子藻酸盐时的粘度为35至80cps 60rpm和纺锤＃1; （ii）所述藻酸盐壳膜包封以所述填充材料的至少50重量％的量存在的油; （iii）所述干燥的无缝胶囊在37℃下在0.1M NaCl和HCl的pH为3的溶液中预处理20分钟后，在肠缓冲液中的崩解时间小于12分钟; 和（iv）所述干燥的无缝胶囊具有至少7kg的干燥断裂强度。 本发明还涉及制造和使用这种干燥无缝胶囊的方法。
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公开(公告)号：WO2007103209A3
公开(公告)日：2008-12-24
申请号：PCT/US2007005436
申请日：2007-03-01
Applicant: FMC BIOPOLYMER AS , FMC CORP , GASEROD OLAV , ANDERSEN THERESE , MELVIK JAN EGIL , DORNISH MICHAEL , RILEY PETER J
Inventor： GASEROD OLAV , ANDERSEN THERESE , MELVIK JAN EGIL , DORNISH MICHAEL , RILEY PETER J
Abstract: The invention relates to composites comprising a polysaccharide gelled within pores of a foam, methods of preparation, and uses thereof, for example, in biomedical applications such as cell culture media and implants, controlled release delivery systems, food applications, industrial applications, and personal care applications such as cosmetic and oral hygiene. The composites of the present invention are simple to formulate using few steps and are useful for entrapping heat-sensitive components, such as cells, drugs, flavors or fragrances within the polysaccharide gel. In addition, the invention provides for a composite able to gently immobilize fragile components, such as living cells, without exposing such components to shear forces.
Abstract translation: 本发明涉及包含在泡沫的孔内凝胶化的多糖的复合材料，制备方法及其用途，例如在生物医学应用中，例如细胞培养基和植入物，控制释放递送系统，食品应用，工业应用和个人 护理应用如化妆品和口腔卫生。 本发明的复合材料使用几个步骤简单的配制，并且可用于在多糖凝胶内捕获热敏组分如细胞，药物，香料或香料。 此外，本发明提供了一种复合材料，其能够轻柔地固定易碎组分如活细胞，而不会使这些组分暴露于剪切力。
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8.发明申请HYDROGELS CONTAINING LOW MOLECULAR WEIGHT ALGINATES AND BIOSTRUCTURES MADE THEREFROM 审中-公开含有低分子量重金属和生物结构的水凝胶
公开(公告)号：WO2008006658A1
公开(公告)日：2008-01-17
申请号：PCT/EP2007/055856
申请日：2007-06-13
Applicant: FMC BIOPOLYMER AS , MCCALL, John D. , MELVIK, Jan Egil , GASEROD, Olav
Inventor： MELVIK, Jan Egil , GASEROD, Olav
CPC classification number: A61K9/06 , A61K9/0024 , A61K33/06 , A61K33/24 , A61K47/36 , A61K47/6903 , A61K51/1213 , A61L24/001 , A61L24/0031 , A61L24/08 , A61L27/20 , A61L27/38 , A61L27/52 , A61L2430/36 , C08L5/04
Abstract: The present invention is directed to a hydrogel comprising an alginate having a low molecular weight (e.g., less than 75,000 Daltons), wherein the alginate is present in a high concentration (e.g., greater than 2.5% by weight of the hydrogel). The present invention is also directed to methods of making and using the hydrogel, as well as products containing the hydrogel.
Abstract translation: 本发明涉及包含低分子量（例如小于75,000道尔顿）的藻酸盐的水凝胶，其中藻酸盐以高浓度存在（例如，大于水凝胶的2.5重量％）。 本发明还涉及制备和使用水凝胶以及含有水凝胶的产品的方法。
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9.发明申请
公开(公告)号：WO2007113454A1
公开(公告)日：2007-10-11
申请号：PCT/GB2006/002807
申请日：2006-07-27
Applicant: RECKITT BENCKISER HEALTHCARE (UK) LIMITED , JOLLIFFE, Ian, Gordon , TRAFFORD, Charles , GASEROD, Olav
Inventor： JOLLIFFE, Ian, Gordon , TRAFFORD, Charles , GASEROD, Olav
IPC: A61K31/734 , A61K9/16 , A61K9/50 , A61K9/20
CPC classification number: A61K9/009 , A61K9/0065 , A61K9/1611 , A61K9/1647 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K9/5073 , A61K9/5084 , A61K31/734
Abstract: An ingestible particulate composition comprises: a. an alginate and/or alginic acid; b. a bicarbonate and/or carbonate; c. an organic acid; and d. an agglomerant, being a compound, such as a low molecular weight polyol, which allows the particulate composition to flow yet which substantially does not release fine particulates into the air. Resulting particulate compositions have excellent flow characteristics, dust suppression, organoleptic properties and stability. They are highly suitable for administration direction into a patient's mouth, and ingested to alleviate oesophageal and gastric conditions.
Abstract translation: 可摄入的颗粒组合物包含：a。 藻酸盐和/或藻酸; 湾 碳酸氢盐和/或碳酸盐; C。 有机酸; 和d。 聚集体，例如低分子量多元醇的化合物，其允许颗粒组合物流动，其基本上不会将微细颗粒释放到空气中。 所得颗粒组合物具有优异的流动特性，抑尘，感官特性和稳定性。 它们非常适合于进入患者口腔的行政方向，并且摄取以减轻食管和胃的状况。
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公开(公告)号：WO2011031617A2
公开(公告)日：2011-03-17
申请号：PCT/US2010/047652
申请日：2010-09-02
Applicant: FMC CORPORATION , GASEROD, Olav , LARSEN, Christian, Klein , ANDERSEN, Peder, Oscar
Inventor： GASEROD, Olav , LARSEN, Christian, Klein , ANDERSEN, Peder, Oscar
CPC classification number: B01J13/046 , A23K40/30 , A23P10/30 , A61K9/4808 , A61K9/4816 , A61K9/4833 , A61K47/02 , A61K47/36 , B01J13/20 , B01J13/206
Abstract: The present invention is directed to a dried seamless capsule comprising an alginate shell membrane encapsulating fill material, wherein: (i) said alginate shell membrane comprises a polyvalent metal ion alginate having: (a) an average M content of from 50%-62% by weight based on the weight of the M and G content, and (b) a viscosity of 35 to 80 cps when measured as a monovalent metal ion alginate in a 3.5% water solution at 20 〬C using a Brookfϊeld LV viscometer at 60 rpm and spindle #1; (ii) said alginate shell membrane encapsulates an oil present in an amount of at least 50% by weight of said fill material; (iii) said dried seamless capsule has a disintegration time of less than 12 minutes in an intestinal buffer after pretreatment for 20 minutes in a solution of 0.1 M NaCl and HCl, pH of 3, at 37 〬C; and (iv) said dried seamless capsule has a dry break force strength of at least 7kg. The present invention is also directed to methods of making and using such dried seamless capsules.
Abstract translation: 本发明涉及包含藻酸盐壳膜包封填充材料的干燥无缝胶囊，其中：（i）所述藻酸盐壳膜包含多价金属离子藻酸盐，其具有：（a）平均M 基于M和G含量的重量为50％-62％的含量，和（b）当在20℃下在3.5％水溶液中以单价金属离子藻酸盐测量时，35至80cps的粘度 使用布鲁克菲尔德LV粘度计，转速60rpm，转子＃1; （ii）所述藻酸盐壳膜包封存在量为所述填充材料的至少50重量％的油; （iii）所述干燥无缝胶囊在37℃下在0.1M NaCl和HCl的溶液中预处理20分钟后，在肠缓冲液中的崩解时间小于12分钟; 和（iv）所述干燥无缝胶囊具有至少7kg的干断裂力强度。 本发明还涉及制造和使用这种干燥无缝胶囊的方法。
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