公开(公告)号：WO2004078169A8

公开(公告)日：2005-04-21

申请号：PCT/IB2004000553

申请日：2004-02-23

Applicant: PFIZER PROD INC ,  CONSTAN ALEXANDER ANGELO ,  KESHARY PRAKASH RAJ ,  MACLEAN DAVID BURTON ,  PARALKAR VISHWAS MADHAV ,  ROMAN DOINA COSMA ,  THOMPSON DAVID DUANE ,  WRIGHT TIMOTHY MICHAEL

Inventor： CONSTAN ALEXANDER ANGELO ,  KESHARY PRAKASH RAJ ,  MACLEAN DAVID BURTON ,  PARALKAR VISHWAS MADHAV ,  ROMAN DOINA COSMA ,  THOMPSON DAVID DUANE ,  WRIGHT TIMOTHY MICHAEL

IPC: A61K31/185 ,  A61K31/415 ,  A61K31/433 ,  A61P1/04 ,  A61P9/02 ,  A61P19/00 ,  A61P27/06

CPC classification number: A61K31/185 ,  A61K31/415 ,  A61K31/433

Abstract: The present invention relates to methods of treating pulmonary hypertension, facilitating joint fusion, facilitating tendon and ligament repair, reducing the occurrence of secondary fracture, treating avascular necrosis, facilitating cartilage repair, facilitating bone healing after limb transplantation, facilitating liver regeneration, facilitating wound healing, reducing the occurrence of gastric ulceration, treating hypertension, facilitating the growth of tooth enamel or finger or toe nails, treating glaucoma, treating ocular hypertension, and repairing damage caused by metastatic bone disease using an EP2 selective receptor agonist.

Abstract translation: 本发明涉及治疗肺动脉高压，促进关节融合，促进肌腱和韧带修复，减少二次骨折的发生，治疗无血管性坏死，促进软骨修复，促进肢体移植后骨愈合，促进肝再生，促进伤口愈合的方法 减少胃溃疡的发生，治疗高血压，促进牙釉质或手指或脚趾指甲的生长，使用EP2选择性受体激动剂治疗青光眼，治疗高眼压症和修复由转移性骨病引起的损伤。

公开(公告)号：WO2017066619A1

公开(公告)日：2017-04-20

申请号：PCT/US2016/057111

申请日：2016-10-14

Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD. ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. ,  ILAN, Yaron ,  HAYDEN, Michael ,  ROMAN, Doina, Cosma ,  AMIT-ROMACH, Einat

Inventor： ILAN, Yaron ,  HAYDEN, Michael ,  ROMAN, Doina, Cosma ,  AMIT-ROMACH, Einat

IPC: A61K9/16 ,  A61K9/22 ,  A61K31/522 ,  A61K31/52

CPC classification number: A61K31/52 ,  A61K9/0053 ,  A61K9/20 ,  A61K9/2846 ,  A61K45/06

Abstract: Methods of treating patients suffering from non-alcoholic fatty liver disease (NAFLD) and non alcoholic steatohepaiitis (NASH), including those also suffering from type II diabetes mellitus (T2DM), with a delayed release pharmaceutical composition comprising 6-mercaptopurine are disclosed.

Abstract translation: 治疗患有非酒精性脂肪肝疾病（NAFLD）和非酒精性脂肪性肝炎（NASH）的患者的方法，所述患者包括也患有II型糖尿病（T2DM）的那些患者，以延迟释放药物组合物 包括6-巯基嘌呤。

公开(公告)号：WO2004078169A1

公开(公告)日：2004-09-16

申请号：PCT/IB2004/000553

申请日：2004-02-23

Applicant: PFIZER PRODUCTS INC. ,  CONSTAN, Alexander, Angelo ,  KESHARY, Prakash, Raj ,  MACLEAN, David, Burton ,  PARALKAR, Vishwas, Madhav ,  ROMAN, Doina, Cosma ,  THOMPSON, David, Duane ,  WRIGHT, Timothy, Michael

Inventor： CONSTAN, Alexander, Angelo ,  KESHARY, Prakash, Raj ,  MACLEAN, David, Burton ,  PARALKAR, Vishwas, Madhav ,  ROMAN, Doina, Cosma ,  THOMPSON, David, Duane ,  WRIGHT, Timothy, Michael

IPC: A61K31/185

CPC classification number: A61K31/185 ,  A61K31/415 ,  A61K31/433

Abstract: The present invention relates to methods of treating pulmonary hypertension, facilitating joint fusion, facilitating tendon and ligament repair, reducing the occurrence of secondary fracture, treating avascular necrosis, facilitating cartilage repair, facilitating bone healing after limb transplantation, facilitating liver regeneration, facilitating wound healing, reducing the occurrence of gastric ulceration, treating hypertension, facilitating the growth of tooth enamel or finger or toe nails, treating glaucoma, treating ocular hypertension, and repairing damage caused by metastatic bone disease using an EP 2 selective receptor agonist.

Abstract translation: 本发明涉及治疗肺动脉高压，促进关节融合，促进肌腱和韧带修复，减少二次骨折的发生，治疗无血管性坏死，促进软骨修复，促进肢体移植后骨愈合，促进肝再生，促进伤口愈合的方法 减少胃溃疡的发生，治疗高血压，促进牙釉质或手指或脚趾指甲的生长，使用EP2选择性受体激动剂治疗青光眼，治疗高眼压症和修复由转移性骨病引起的损伤。